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Open data
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Basic information
Entry | Database: PDB / ID: 1qpl | ||||||
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Title | FK506 BINDING PROTEIN (12 KDA, HUMAN) COMPLEX WITH L-707,587 | ||||||
![]() | PROTEIN (FK506-BINDING PROTEIN) | ||||||
![]() | ISOMERASE / IMMUNOPHILIN-DRUG COMPLEX / CIS-TRANS ISOMERASE / PEPTIDYL-PROLYL ISOMERASE | ||||||
Function / homology | ![]() macrolide binding / activin receptor binding / cytoplasmic side of membrane / signaling receptor inhibitor activity / transforming growth factor beta receptor binding / TGFBR1 LBD Mutants in Cancer / type I transforming growth factor beta receptor binding / negative regulation of activin receptor signaling pathway / heart trabecula formation / terminal cisterna ...macrolide binding / activin receptor binding / cytoplasmic side of membrane / signaling receptor inhibitor activity / transforming growth factor beta receptor binding / TGFBR1 LBD Mutants in Cancer / type I transforming growth factor beta receptor binding / negative regulation of activin receptor signaling pathway / heart trabecula formation / terminal cisterna / ryanodine receptor complex / I-SMAD binding / regulation of amyloid precursor protein catabolic process / protein maturation by protein folding / ventricular cardiac muscle tissue morphogenesis / 'de novo' protein folding / negative regulation of phosphoprotein phosphatase activity / FK506 binding / mTORC1-mediated signalling / TGF-beta receptor signaling activates SMADs / Calcineurin activates NFAT / regulation of immune response / protein peptidyl-prolyl isomerization / heart morphogenesis / supramolecular fiber organization / regulation of ryanodine-sensitive calcium-release channel activity / sarcoplasmic reticulum membrane / T cell activation / TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) / peptidylprolyl isomerase / sarcoplasmic reticulum / peptidyl-prolyl cis-trans isomerase activity / calcium ion transmembrane transport / negative regulation of transforming growth factor beta receptor signaling pathway / Z disc / SARS-CoV-1 activates/modulates innate immune responses / regulation of protein localization / protein folding / positive regulation of protein binding / protein refolding / positive regulation of canonical NF-kappaB signal transduction / transmembrane transporter binding / amyloid fibril formation / Potential therapeutics for SARS / membrane / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Becker, J.W. / Rotonda, J. | ||||||
![]() | ![]() Title: 32-Indolyl ether derivatives of ascomycin: three-dimensional structures of complexes with FK506-binding protein. Authors: Becker, J.W. / Rotonda, J. / Cryan, J.G. / Martin, M. / Parsons, W.H. / Sinclair, P.J. / Wiederrecht, G. / Wong, F. #1: ![]() Title: A Tacrolimus-Related Immunosuppressant with Biochemical Properties Distinct from Those of Tacrolimus. Authors: Peterson, L.B. / Cryan, J.G. / Rosa, R. / Martin, M.M. / Wilusz, M.B. / Sinclair, P.J. / Wong, F. / Parsons, J.N. / O'Keefe, S.J. / Parsons, W.H. / Wyvratt, M. / Sigal, N.H. / Williamson, A. ...Authors: Peterson, L.B. / Cryan, J.G. / Rosa, R. / Martin, M.M. / Wilusz, M.B. / Sinclair, P.J. / Wong, F. / Parsons, J.N. / O'Keefe, S.J. / Parsons, W.H. / Wyvratt, M. / Sigal, N.H. / Williamson, A.R. / Wiederrecht, G.J. #2: ![]() Title: A Tacrolimus-Related Immunosuppressant with Reduced Toxicity. Authors: Dumont, F.J. / Koprak, S. / Staruch, M.J. / Talento, A. / Koo, G. / Dasilva, C. / Sinclair, P.J. / Wong, F. / Woods, J. / Barker, J. / Pivnichny, J. / Singer, I. / Sigal, N.H. / Williamson, ...Authors: Dumont, F.J. / Koprak, S. / Staruch, M.J. / Talento, A. / Koo, G. / Dasilva, C. / Sinclair, P.J. / Wong, F. / Woods, J. / Barker, J. / Pivnichny, J. / Singer, I. / Sigal, N.H. / Williamson, A.R. / Parsons, W.H. / Wyvratt, M. #3: ![]() Title: Preparation and in Vitro Activities of Naphthyl and Indolyl Ether Derivatives of the Fk-506 Related Immunosuppressive Macrolide Ascomycin. Authors: Sinclair, P.J. / Wong, F. / Staruch, M.J. / Wiederrecht, G. / Parsons, W.H. / Dumont, F. / Wyvratt, M. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 55.4 KB | Display | ![]() |
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PDB format | ![]() | 39.8 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 991.9 KB | Display | ![]() |
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Full document | ![]() | 997.4 KB | Display | |
Data in XML | ![]() | 11.8 KB | Display | |
Data in CIF | ![]() | 14.1 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 1qpfC ![]() 1fkdS S: Starting model for refinement C: citing same article ( |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 11836.508 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() #2: Chemical | #3: Water | ChemComp-HOH / | |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 3.98 Å3/Da / Density % sol: 69.1 % | |||||||||||||||
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Crystal grow | pH: 6.1 / Details: AMMONIUM SULFATE, POTASSIUM PHOSPHATE, pH 6.1 | |||||||||||||||
Crystal grow | *PLUS Method: vapor diffusion | |||||||||||||||
Components of the solutions | *PLUS
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-Data collection
Diffraction | Mean temperature: 298 K |
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Diffraction source | Source: ![]() |
Detector | Type: SIEMENS / Detector: AREA DETECTOR / Date: Jun 30, 1991 |
Radiation | Monochromator: GRAPHITE / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.54178 Å / Relative weight: 1 |
Reflection | Resolution: 2.5→42.33 Å / Num. obs: 12979 / % possible obs: 85.1 % / Observed criterion σ(I): 0 / Redundancy: 6.41 % / Biso Wilson estimate: 68.48 Å2 / Rmerge(I) obs: 0.0585 / Net I/σ(I): 29.28 |
Reflection shell | Resolution: 2.5→2.61 Å / % possible all: 57.2 |
Reflection shell | *PLUS % possible obs: 57.2 % |
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Processing
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Refinement | Method to determine structure: ![]() Starting model: PROTEIN PORTION OF PDB ENTRY 1FKD Resolution: 2.9→20 Å / Rfactor Rfree error: 0.01 / Data cutoff high absF: 10000000 / Data cutoff low absF: 0 / Isotropic thermal model: GROUP / Cross valid method: A POSTERIORI / σ(F): 2
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Displacement parameters | Biso mean: 59.5 Å2
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Refine analyze |
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Refinement step | Cycle: LAST / Resolution: 2.9→20 Å
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Refine LS restraints |
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LS refinement shell | Resolution: 2.9→3 Å / Rfactor Rfree error: 0.05 / Total num. of bins used: 10
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Software | *PLUS Name: ![]() | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine LS restraints | *PLUS
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