登録情報 データベース : PDB / ID : 1n7d 構造の表示 ダウンロードとリンクタイトル Extracellular domain of the LDL receptor 要素Low-density lipoprotein receptor 詳細 キーワード LIPID TRANSPORT / LDL-Receptor / familial hypercholesterolemia / LDL / cholesterol metabolism機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
receptor-mediated endocytosis involved in cholesterol transport / regulation of phosphatidylcholine catabolic process / plasma lipoprotein particle clearance / positive regulation of lysosomal protein catabolic process / very-low-density lipoprotein particle receptor activity / negative regulation of astrocyte activation / negative regulation of microglial cell activation / PCSK9-LDLR complex / cholesterol import / low-density lipoprotein particle clearance ... receptor-mediated endocytosis involved in cholesterol transport / regulation of phosphatidylcholine catabolic process / plasma lipoprotein particle clearance / positive regulation of lysosomal protein catabolic process / very-low-density lipoprotein particle receptor activity / negative regulation of astrocyte activation / negative regulation of microglial cell activation / PCSK9-LDLR complex / cholesterol import / low-density lipoprotein particle clearance / negative regulation of receptor recycling / clathrin heavy chain binding / low-density lipoprotein particle receptor activity / intestinal cholesterol absorption / positive regulation of triglyceride biosynthetic process / negative regulation of low-density lipoprotein particle clearance / low-density lipoprotein particle binding / Chylomicron clearance / response to caloric restriction / amyloid-beta clearance by cellular catabolic process / LDL clearance / regulation of protein metabolic process / high-density lipoprotein particle clearance / lipoprotein catabolic process / phospholipid transport / low-density lipoprotein particle / cholesterol transport / endolysosome membrane / negative regulation of amyloid fibril formation / negative regulation of protein metabolic process / artery morphogenesis / cellular response to fatty acid / regulation of cholesterol metabolic process / amyloid-beta clearance / sorting endosome / lipoprotein particle binding / cellular response to low-density lipoprotein particle stimulus / long-term memory / phagocytosis / Retinoid metabolism and transport / clathrin-coated pit / somatodendritic compartment / cholesterol metabolic process / receptor-mediated endocytosis / cholesterol homeostasis / clathrin-coated endocytic vesicle membrane / lipid metabolic process / positive regulation of inflammatory response / endocytosis / late endosome / Cargo recognition for clathrin-mediated endocytosis / apical part of cell / Clathrin-mediated endocytosis / virus receptor activity / amyloid-beta binding / protease binding / basolateral plasma membrane / molecular adaptor activity / early endosome / receptor complex / lysosome / endosome membrane / external side of plasma membrane / negative regulation of gene expression / calcium ion binding / positive regulation of gene expression / Golgi apparatus / cell surface / identical protein binding / membrane / plasma membrane 類似検索 - 分子機能 Knottins (small inhibitors, toxins, lectins) / EGF-type module / Low-density Lipoprotein Receptor / Low-density Lipoprotein Receptor / : / Complement Clr-like EGF-like / TolB, C-terminal domain / Low-density lipoprotein receptor repeat class B / LDL-receptor class B (LDLRB) repeat profile. / LDLR class B repeat ... Knottins (small inhibitors, toxins, lectins) / EGF-type module / Low-density Lipoprotein Receptor / Low-density Lipoprotein Receptor / : / Complement Clr-like EGF-like / TolB, C-terminal domain / Low-density lipoprotein receptor repeat class B / LDL-receptor class B (LDLRB) repeat profile. / LDLR class B repeat / Low-density lipoprotein-receptor YWTD domain / Low-density lipoprotein receptor domain class A / : / Low-density lipoprotein (LDL) receptor class A, conserved site / LDL-receptor class A (LDLRA) domain signature. / LDL-receptor class A (LDLRA) domain profile. / Calcium-binding EGF domain / Low-density lipoprotein receptor domain class A / Low-density lipoprotein (LDL) receptor class A repeat / LDL receptor-like superfamily / Six-bladed beta-propeller, TolB-like / Laminin / Coagulation Factor Xa inhibitory site / Laminin / EGF-type aspartate/asparagine hydroxylation site / 6 Propeller / Neuraminidase / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Epidermal growth factor-like domain. / EGF-like domain profile. / Growth factor receptor cysteine-rich domain superfamily / EGF-like domain signature 2. / EGF-like domain / Ribbon / Few Secondary Structures / Irregular / Mainly Beta 類似検索 - ドメイン・相同性 12-TUNGSTOPHOSPHATE / Low-density lipoprotein receptor 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 多波長異常分散 / 解像度 : 3.7 Å 詳細データ登録者 Rudenko, G. / Henry, L. / Henderson, K. / Ichtchenko, K. / Brown, M.S. / Goldstein, J.L. / Deisenhofer, J. 引用ジャーナル : Science / 年 : 2002タイトル : Structure of the LDL receptor extracellular domain at endosomal pH著者 : Rudenko, G. / Henry, L. / Henderson, K. / Ichtchenko, K. / Brown, M.S. / Goldstein, J.L. / Deisenhofer, J. 履歴 登録 2002年11月13日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2003年1月21日 Provider : repository / タイプ : Initial release改定 1.1 2008年4月28日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Non-polymer description / Version format compliance改定 2.0 2020年7月29日 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Derived calculations / Structure summary カテゴリ : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_conn_angle / pdbx_struct_special_symmetry / pdbx_unobs_or_zero_occ_atoms / pdbx_validate_close_contact / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.Cartn_x / _atom_site.Cartn_y ... _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_entity_id / _chem_comp.name / _chem_comp.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_special_symmetry.label_asym_id / _pdbx_unobs_or_zero_occ_atoms.label_asym_id / _pdbx_validate_close_contact.auth_asym_id_2 / _pdbx_validate_close_contact.auth_seq_id_2 / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation改定 2.1 2021年10月27日 Group : Database references / Structure summary / カテゴリ : chem_comp / database_2 / struct_ref_seq_difItem : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
すべて表示 表示を減らす Remark 300 BIOMOLECULE: 1 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT WHICH CONSISTS OF 1 CHAIN(S) ... BIOMOLECULE: 1 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT WHICH CONSISTS OF 1 CHAIN(S). SEE REMARK 350 FOR INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S). THE AUTHORS BELIEVE THE BIOLOGICAL UNIT IS A MONOMER. Remark 600 HETEROGEN THE ATOMS W1 AND W2 OF THE LIGAND KEG 6003 ARE ON A TWO-FOLD AXIS. COORDINATES FOR THE ... HETEROGEN THE ATOMS W1 AND W2 OF THE LIGAND KEG 6003 ARE ON A TWO-FOLD AXIS. COORDINATES FOR THE HALF OF THE CLUSTER KEG 6003 IN THE ASYMMETRIC UNIT ARE INCLUDED IN THIS ENTRY. THE SECOND HALF OF THE CLUSTER CAN BE GENERATED USING SYMMETRY OPERATION Y,X,1-Z.