登録情報 データベース : PDB / ID : 1mu8 構造の表示 ダウンロードとリンクタイトル thrombin-hirugen_l-378,650 要素(THROMBIN) x 2 HIRUDIN IIB 詳細キーワード HYDROLASE/HYDROLASE INHIBITOR / thrombin-hirugen / BLOOD CLOTTING / HYDROLASE-HYDROLASE INHIBITOR COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
cytolysis by host of symbiont cells / thrombospondin receptor activity / thrombin-activated receptor signaling pathway / Defective factor XII causes hereditary angioedema / thrombin / negative regulation of astrocyte differentiation / regulation of blood coagulation / positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway / neutrophil-mediated killing of gram-negative bacterium / Defective F8 cleavage by thrombin ... cytolysis by host of symbiont cells / thrombospondin receptor activity / thrombin-activated receptor signaling pathway / Defective factor XII causes hereditary angioedema / thrombin / negative regulation of astrocyte differentiation / regulation of blood coagulation / positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway / neutrophil-mediated killing of gram-negative bacterium / Defective F8 cleavage by thrombin / Platelet Aggregation (Plug Formation) / ligand-gated ion channel signaling pathway / positive regulation of collagen biosynthetic process / negative regulation of platelet activation / negative regulation of blood coagulation / positive regulation of blood coagulation / negative regulation of fibrinolysis / regulation of cytosolic calcium ion concentration / Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus / Gamma-carboxylation of protein precursors / Common Pathway of Fibrin Clot Formation / Removal of aminoterminal propeptides from gamma-carboxylated proteins / fibrinolysis / Intrinsic Pathway of Fibrin Clot Formation / negative regulation of proteolysis / negative regulation of cytokine production involved in inflammatory response / positive regulation of release of sequestered calcium ion into cytosol / Peptide ligand-binding receptors / Regulation of Complement cascade / acute-phase response / Cell surface interactions at the vascular wall / positive regulation of receptor signaling pathway via JAK-STAT / lipopolysaccharide binding / growth factor activity / serine-type endopeptidase inhibitor activity / positive regulation of insulin secretion / platelet activation / response to wounding / Golgi lumen / positive regulation of protein localization to nucleus / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / positive regulation of reactive oxygen species metabolic process / blood coagulation / antimicrobial humoral immune response mediated by antimicrobial peptide / regulation of cell shape / heparin binding / Thrombin signalling through proteinase activated receptors (PARs) / : / positive regulation of cell growth / blood microparticle / G alpha (q) signalling events / cell surface receptor signaling pathway / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / receptor ligand activity / endoplasmic reticulum lumen / signaling receptor binding / serine-type endopeptidase activity / positive regulation of cell population proliferation / calcium ion binding / proteolysis / extracellular space / extracellular exosome / extracellular region / plasma membrane 類似検索 - 分子機能 Hirudin / Proteinase inhibitor I14, hirudin / Thrombin inhibitor hirudin / Hirudin/antistatin / Prothrombin/thrombin / Thrombin light chain / Thrombin light chain domain superfamily / : / Thrombin light chain / Kringle domain ... Hirudin / Proteinase inhibitor I14, hirudin / Thrombin inhibitor hirudin / Hirudin/antistatin / Prothrombin/thrombin / Thrombin light chain / Thrombin light chain domain superfamily / : / Thrombin light chain / Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain / Gamma-carboxyglutamic acid-rich (GLA) domain / Gamma-carboxyglutamic acid-rich (GLA) domain superfamily / Vitamin K-dependent carboxylation domain. / Gla domain profile. / Domain containing Gla (gamma-carboxyglutamate) residues. / Kringle-like fold / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Serine proteases, trypsin family, histidine active site. / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, serine active site. / Serine proteases, trypsin domain profile. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases / Thrombin, subunit H / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)Hirudo medicinalis (医用ビル)手法 X線回折 / フーリエ合成 / 解像度 : 2 Å 詳細データ登録者 Burgey, C.S. / Robinson, K.A. / Lyle, T.A. / Sanderson, P.E. / Lewis, S.D. / Lucas, B.J. / Krueger, J.A. / Singh, R. / Miller-Stein, C. / White, R.B. ...Burgey, C.S. / Robinson, K.A. / Lyle, T.A. / Sanderson, P.E. / Lewis, S.D. / Lucas, B.J. / Krueger, J.A. / Singh, R. / Miller-Stein, C. / White, R.B. / Wong, B. / Lyle, E.A. / Williams, P.D. / Coburn, C.A. / Dorsey, B.D. / Barrow, J.C. / Stranieri, M.T. / Holahan, M.A. / Sitko, G.R. / Cook, J.J. / McMasters, D.R. / McDonough, C.M. / Sanders, W.M. / Wallace, A.A. / Clayton, F.C. / Bohn, D. / Leonard, Y.M. / Detwiler Jr., T.J. / Lynch Jr., J.J. / Yan, Y. / Chen, Z. / Kuo, L. / Gardell, S.J. / Shafer, J.A. / Vacca, J.P.J. 引用ジャーナル : J.Med.Chem. / 年 : 2003タイトル : Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines.著者: Burgey, C.S. / Robinson, K.A. / Lyle, T.A. / Sanderson, P.E. / Lewis, S.D. / Lucas, B.J. / Krueger, J.A. / Singh, R. / Miller-Stein, C. / White, R.B. / Wong, B. / Lyle, E.A. / Williams, P.D. ... 著者 : Burgey, C.S. / Robinson, K.A. / Lyle, T.A. / Sanderson, P.E. / Lewis, S.D. / Lucas, B.J. / Krueger, J.A. / Singh, R. / Miller-Stein, C. / White, R.B. / Wong, B. / Lyle, E.A. / Williams, P.D. / Coburn, C.A. / Dorsey, B.D. / Barrow, J.C. / Stranieri, M.T. / Holahan, M.A. / Sitko, G.R. / Cook, J.J. / McMasters, D.R. / McDonough, C.M. / Sanders, W.M. / Wallace, A.A. / Clayton, F.C. / Bohn, D. / Leonard, Y.M. / Detwiler Jr., T.J. / Lynch Jr., J.J. / Yan, Y. / Chen, Z. / Kuo, L. / Gardell, S.J. / Shafer, J.A. / Vacca, J.P.J. 履歴 登録 2002年9月23日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2004年4月6日 Provider : repository / タイプ : Initial release改定 1.1 2008年4月28日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Atomic model / Database references ... Atomic model / Database references / Derived calculations / Non-polymer description / Structure summary / Version format compliance 改定 1.3 2012年12月12日 Group : Other改定 1.4 2013年3月13日 Group : Other改定 1.5 2016年5月25日 Group : Source and taxonomy改定 1.6 2017年10月11日 Group : Refinement description / カテゴリ : software改定 1.7 2021年7月21日 Group : Data collection / Derived calculations / Refinement descriptionカテゴリ : refine / reflns ... refine / reflns / struct_conn / struct_site Item : _refine.ls_percent_reflns_obs / _refine.pdbx_ls_cross_valid_method ... _refine.ls_percent_reflns_obs / _refine.pdbx_ls_cross_valid_method / _reflns.percent_possible_obs / _struct_conn.pdbx_leaving_atom_flag / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id 改定 1.8 2024年11月20日 Group : Data collection / Database references / Structure summaryカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_modification_feature Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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