Entry Database : PDB / ID : 1z71 Structure visualization Downloads & linksTitle thrombin and P2 pyridine N-oxide inhibitor complex structure Components Details Keywords HYDROLASE/HYDROLASE INHIBITOR / thrombin inhibitor complex / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of lipid kinase activity / cytolysis by host of symbiont cells / positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway / thrombospondin receptor activity / Defective factor XII causes hereditary angioedema / thrombin / regulation of blood coagulation / neutrophil-mediated killing of gram-negative bacterium / ligand-gated ion channel signaling pathway / Defective F8 cleavage by thrombin ... positive regulation of lipid kinase activity / cytolysis by host of symbiont cells / positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway / thrombospondin receptor activity / Defective factor XII causes hereditary angioedema / thrombin / regulation of blood coagulation / neutrophil-mediated killing of gram-negative bacterium / ligand-gated ion channel signaling pathway / Defective F8 cleavage by thrombin / Platelet Aggregation (Plug Formation) / negative regulation of astrocyte differentiation / negative regulation of platelet activation / positive regulation of collagen biosynthetic process / negative regulation of cytokine production involved in inflammatory response / positive regulation of blood coagulation / negative regulation of fibrinolysis / Gamma-carboxylation of protein precursors / Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus / Common Pathway of Fibrin Clot Formation / Removal of aminoterminal propeptides from gamma-carboxylated proteins / fibrinolysis / regulation of cytosolic calcium ion concentration / Intrinsic Pathway of Fibrin Clot Formation / Peptide ligand-binding receptors / positive regulation of release of sequestered calcium ion into cytosol / acute-phase response / Regulation of Complement cascade / negative regulation of proteolysis / Cell surface interactions at the vascular wall / lipopolysaccharide binding / positive regulation of receptor signaling pathway via JAK-STAT / growth factor activity / serine-type endopeptidase inhibitor activity / positive regulation of insulin secretion / platelet activation / response to wounding / positive regulation of protein localization to nucleus / Golgi lumen / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / positive regulation of reactive oxygen species metabolic process / blood coagulation / antimicrobial humoral immune response mediated by antimicrobial peptide / Thrombin signalling through proteinase activated receptors (PARs) / heparin binding / regulation of cell shape / positive regulation of cell growth / G alpha (q) signalling events / collagen-containing extracellular matrix / blood microparticle / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cell surface receptor signaling pathway / positive regulation of protein phosphorylation / G protein-coupled receptor signaling pathway / endoplasmic reticulum lumen / serine-type endopeptidase activity / signaling receptor binding / positive regulation of cell population proliferation / calcium ion binding / proteolysis / extracellular space / extracellular exosome / extracellular region / plasma membrane Similarity search - Function Hirudin / Proteinase inhibitor I14, hirudin / Thrombin inhibitor hirudin / Hirudin/antistatin / Prothrombin/thrombin / Thrombin light chain / Thrombin light chain domain superfamily / : / Thrombin light chain / Kringle domain ... Hirudin / Proteinase inhibitor I14, hirudin / Thrombin inhibitor hirudin / Hirudin/antistatin / Prothrombin/thrombin / Thrombin light chain / Thrombin light chain domain superfamily / : / Thrombin light chain / Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain / Gamma-carboxyglutamic acid-rich (GLA) domain / Gamma-carboxyglutamic acid-rich (GLA) domain superfamily / Vitamin K-dependent carboxylation domain. / Gla domain profile. / Domain containing Gla (gamma-carboxyglutamate) residues. / Kringle-like fold / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin family, serine active site. / Serine proteases, trypsin domain profile. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases / Thrombin, subunit H / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Beta Barrel / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Hirudo medicinalis (medicinal leech)Method X-RAY DIFFRACTION / FOURIER SYNTHESIS / Resolution : 1.8 Å DetailsAuthors Nantermet, P.G. / Burgey, C.S. / Robinson, K.A. / Pellicore, J.M. / Newton, C.L. / Deng, J.Z. / Lyle, T.A. / Selnick, H.G. / Lewis, S.D. / Lucas, B.J. ...Nantermet, P.G. / Burgey, C.S. / Robinson, K.A. / Pellicore, J.M. / Newton, C.L. / Deng, J.Z. / Lyle, T.A. / Selnick, H.G. / Lewis, S.D. / Lucas, B.J. / Krueger, J.A. / Miller-Stein, C. / White, R.B. / Wong, B. / McMasters, D.R. / Wallace, A.A. / Lynch Jr., J.J. / Yan, Y. / Chen, Z. / Kuo, L. / Gardell, S.J. / Shafer, J.A. / Vacca, J.P. CitationJournal : BIOORG.MED.CHEM.LETT. / Year : 2005Title : P(2) pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffoldAuthors: Nantermet, P.G. / Burgey, C.S. / Robinson, K.A. / Pellicore, J.M. / Newton, C.L. / Deng, J.Z. / Selnick, H.G. / Lewis, S.D. / Lucas, B.J. / Krueger, J.A. / Miller-Stein, C. / White, R.B. / ... Authors : Nantermet, P.G. / Burgey, C.S. / Robinson, K.A. / Pellicore, J.M. / Newton, C.L. / Deng, J.Z. / Selnick, H.G. / Lewis, S.D. / Lucas, B.J. / Krueger, J.A. / Miller-Stein, C. / White, R.B. / Wong, B. / McMasters, D.R. / Wallace, A.A. / Lynch Jr., J.J. / Yan, Y. / Chen, Z. / Kuo, L. / Gardell, S.J. / Shafer, J.A. / Vacca, J.P. / Lyle, T.A. History Deposition Mar 23, 2005 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 17, 2005 Provider : repository / Type : Initial releaseRevision 1.1 Apr 30, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Atomic model / Database references ... Atomic model / Database references / Derived calculations / Non-polymer description / Structure summary / Version format compliance Revision 1.3 Dec 12, 2012 Group : OtherRevision 1.4 Mar 13, 2013 Group : OtherRevision 1.5 Oct 11, 2017 Group : Refinement description / Category : softwareRevision 1.6 Oct 16, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Structure summary Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_modification_feature / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
Show all Show less Remark 999 SEQUENCE According to authors, Hirugen was chemically synthesized.