Entry Database : PDB / ID : 1ta6 Structure visualization Downloads & linksTitle Crystal structure of thrombin in complex with compound 14b Components Details Keywords HYDROLASE/HYDROLASE INHIBITOR / thrombin inhibitor complex / BLOOD CLOTTING / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of lipid kinase activity / positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway / cytolysis by host of symbiont cells / thrombospondin receptor activity / Defective factor XII causes hereditary angioedema / thrombin / regulation of blood coagulation / neutrophil-mediated killing of gram-negative bacterium / ligand-gated ion channel signaling pathway / Defective F8 cleavage by thrombin ... positive regulation of lipid kinase activity / positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway / cytolysis by host of symbiont cells / thrombospondin receptor activity / Defective factor XII causes hereditary angioedema / thrombin / regulation of blood coagulation / neutrophil-mediated killing of gram-negative bacterium / ligand-gated ion channel signaling pathway / Defective F8 cleavage by thrombin / Platelet Aggregation (Plug Formation) / negative regulation of astrocyte differentiation / negative regulation of platelet activation / positive regulation of collagen biosynthetic process / negative regulation of cytokine production involved in inflammatory response / positive regulation of blood coagulation / negative regulation of fibrinolysis / Gamma-carboxylation of protein precursors / Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus / Common Pathway of Fibrin Clot Formation / Removal of aminoterminal propeptides from gamma-carboxylated proteins / fibrinolysis / regulation of cytosolic calcium ion concentration / Intrinsic Pathway of Fibrin Clot Formation / Peptide ligand-binding receptors / positive regulation of release of sequestered calcium ion into cytosol / acute-phase response / Regulation of Complement cascade / negative regulation of proteolysis / Cell surface interactions at the vascular wall / lipopolysaccharide binding / positive regulation of receptor signaling pathway via JAK-STAT / growth factor activity / serine-type endopeptidase inhibitor activity / positive regulation of insulin secretion / platelet activation / response to wounding / positive regulation of protein localization to nucleus / Golgi lumen / antimicrobial humoral immune response mediated by antimicrobial peptide / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / positive regulation of reactive oxygen species metabolic process / blood coagulation / Thrombin signalling through proteinase activated receptors (PARs) / heparin binding / regulation of cell shape / positive regulation of cell growth / G alpha (q) signalling events / collagen-containing extracellular matrix / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cell surface receptor signaling pathway / blood microparticle / positive regulation of protein phosphorylation / G protein-coupled receptor signaling pathway / endoplasmic reticulum lumen / serine-type endopeptidase activity / signaling receptor binding / calcium ion binding / positive regulation of cell population proliferation / proteolysis / extracellular space / extracellular exosome / extracellular region / plasma membrane Similarity search - Function Thrombin inhibitor hirudin / Hirudin / Proteinase inhibitor I14, hirudin / Hirudin/antistatin / Prothrombin/thrombin / Thrombin light chain / Thrombin light chain domain superfamily / Thrombin light chain / Kringle domain / Kringle ... Thrombin inhibitor hirudin / Hirudin / Proteinase inhibitor I14, hirudin / Hirudin/antistatin / Prothrombin/thrombin / Thrombin light chain / Thrombin light chain domain superfamily / Thrombin light chain / Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain / Gamma-carboxyglutamic acid-rich (GLA) domain / Gamma-carboxyglutamic acid-rich (GLA) domain superfamily / Vitamin K-dependent carboxylation domain. / Gla domain profile. / Domain containing Gla (gamma-carboxyglutamate) residues. / Kringle-like fold / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases / Thrombin, subunit H / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Beta Barrel / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Hirudo medicinalis (medicinal leech)Method X-RAY DIFFRACTION / FOURIER SYNTHESIS / Resolution : 1.9 Å DetailsAuthors Tucker, T.J. / Brady, S.F. / Lumma, W.C. / Lewis, S.D. / Gardel, S.J. / Naylor-Olsen, A.M. / Yan, Y. / Sisko, J.T. / Stauffer, K.J. / Lucas, B.Y. ...Tucker, T.J. / Brady, S.F. / Lumma, W.C. / Lewis, S.D. / Gardel, S.J. / Naylor-Olsen, A.M. / Yan, Y. / Sisko, J.T. / Stauffer, K.J. / Lucas, B.Y. / Lynch, J.J. / Cook, J.J. / Stranieri, M.T. / Holahan, M.A. / Lyle, E.A. / Baskin, E.P. / Chen, I.-W. / Dancheck, K.B. / Krueger, J.A. / Cooper, C.M. / Vacca, J.P. CitationJournal : J.Med.Chem. / Year : 1998Title : Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 positionAuthors: Tucker, T.J. / Brady, S.F. / Lumma, W.C. / Lewis, S.D. / Gardel, S.J. / Naylor-Olsen, A.M. / Yan, Y. / Sisko, J.T. / Stauffer, K.J. / Lucas, B.Y. / Lynch, J.J. / Cook, J.J. / Stranieri, M.T. ... Authors : Tucker, T.J. / Brady, S.F. / Lumma, W.C. / Lewis, S.D. / Gardel, S.J. / Naylor-Olsen, A.M. / Yan, Y. / Sisko, J.T. / Stauffer, K.J. / Lucas, B.Y. / Lynch, J.J. / Cook, J.J. / Stranieri, M.T. / Holahan, M.A. / Lyle, E.A. / Baskin, E.P. / Chen, I.-W. / Dancheck, K.B. / Krueger, J.A. / Cooper, C.M. / Vacca, J.P. History Deposition May 19, 2004 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 8, 2004 Provider : repository / Type : Initial releaseRevision 1.1 Apr 30, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Atomic model / Database references ... Atomic model / Database references / Derived calculations / Non-polymer description / Structure summary / Version format compliance Revision 1.3 Oct 11, 2017 Group : Refinement description / Category : software
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