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| Title | Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 41, Page 3210-3219, Year 1998 |
| Publish date | May 19, 2004 (structure data deposition date) |
 Authors | Tucker, T.J. / Brady, S.F. / Lumma, W.C. / Lewis, S.D. / Gardel, S.J. / Naylor-Olsen, A.M. / Yan, Y. / Sisko, J.T. / Stauffer, K.J. / Lucas, B.Y. ...Tucker, T.J. / Brady, S.F. / Lumma, W.C. / Lewis, S.D. / Gardel, S.J. / Naylor-Olsen, A.M. / Yan, Y. / Sisko, J.T. / Stauffer, K.J. / Lucas, B.Y. / Lynch, J.J. / Cook, J.J. / Stranieri, M.T. / Holahan, M.A. / Lyle, E.A. / Baskin, E.P. / Chen, I.-W. / Dancheck, K.B. / Krueger, J.A. / Cooper, C.M. / Vacca, J.P. |
 External links | J. Med. Chem. / PubMed:9703466 |
| Methods | X-ray diffraction |
| Resolution | 1.9 - 2.3 Å |
| Structure data |  PDB-1ta2:  PDB-1ta6: |
| Chemicals |  ChemComp-176:  ChemComp-HOH:  ChemComp-177: |
| Source |
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 Keywords | HYDROLASE/HYDROLASE INHIBITOR / thrombin inhibitor complex / BLOOD CLOTTING / HYDROLASE / HYDROLASE-HYDROLASE INHIBITOR COMPLEX |
homo sapiens (human)
hirudo medicinalis (medicinal leech)