登録情報 データベース : PDB / ID : 1j4r 構造の表示 ダウンロードとリンクタイトル FK506 BINDING PROTEIN COMPLEXED WITH FKB-001 要素FK506-BINDING PROTEIN 詳細 キーワード ISOMERASE / ROTAMASE / INHIBITOR機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
macrolide binding / activin receptor binding / regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion / cytoplasmic side of membrane / transforming growth factor beta receptor binding / TGFBR1 LBD Mutants in Cancer / type I transforming growth factor beta receptor binding / negative regulation of activin receptor signaling pathway / heart trabecula formation / I-SMAD binding ... macrolide binding / activin receptor binding / regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion / cytoplasmic side of membrane / transforming growth factor beta receptor binding / TGFBR1 LBD Mutants in Cancer / type I transforming growth factor beta receptor binding / negative regulation of activin receptor signaling pathway / heart trabecula formation / I-SMAD binding / signaling receptor inhibitor activity / regulation of amyloid precursor protein catabolic process / terminal cisterna / ryanodine receptor complex / 'de novo' protein folding / ventricular cardiac muscle tissue morphogenesis / FK506 binding / TGF-beta receptor signaling activates SMADs / mTORC1-mediated signalling / Calcineurin activates NFAT / regulation of ryanodine-sensitive calcium-release channel activity / regulation of immune response / heart morphogenesis / supramolecular fiber organization / sarcoplasmic reticulum membrane / calcium channel regulator activity / protein maturation / T cell activation / sarcoplasmic reticulum / peptidyl-prolyl cis-trans isomerase activity / TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) / RNA polymerase II CTD heptapeptide repeat P3 isomerase activity / RNA polymerase II CTD heptapeptide repeat P6 isomerase activity / peptidylprolyl isomerase / negative regulation of transforming growth factor beta receptor signaling pathway / Z disc / SARS-CoV-1 activates/modulates innate immune responses / protein folding / regulation of protein localization / protein refolding / amyloid fibril formation / Potential therapeutics for SARS / transmembrane transporter binding / positive regulation of canonical NF-kappaB signal transduction / membrane / cytosol / cytoplasm 類似検索 - 分子機能 Chitinase A; domain 3 - #40 / : / Chitinase A; domain 3 / FKBP-type peptidyl-prolyl cis-trans isomerase / FKBP-type peptidyl-prolyl cis-trans isomerase domain / FKBP-type peptidyl-prolyl cis-trans isomerase domain profile. / Peptidyl-prolyl cis-trans isomerase domain superfamily / Roll / Alpha Beta 類似検索 - ドメイン・相同性 Chem-001 / Peptidyl-prolyl cis-trans isomerase FKBP1A 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 1.8 Å 詳細データ登録者 Sheriff, S. 引用ジャーナル : Org.Lett. / 年 : 2001タイトル : 2-Aryl-2,2-difluoroacetamide FKBP12 ligands: synthesis and X-ray structural studies.著者 : Dubowchik, G.M. / Vrudhula, V.M. / Dasgupta, B. / Ditta, J. / Chen, T. / Sheriff, S. / Sipman, K. / Witmer, M. / Tredup, J. / Vyas, D.M. / Verdoorn, T.A. / Bollini, S. / Vinitsky, A. 履歴 登録 2001年10月29日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2001年12月19日 Provider : repository / タイプ : Initial release改定 1.1 2008年4月26日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Non-polymer description / Version format compliance改定 1.3 2017年10月4日 Group : Refinement description / カテゴリ : software改定 1.4 2023年8月16日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
すべて表示 表示を減らす Remark 300 BIOMOLECULE: 1, 2, 3 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT WHICH CONSISTS OF 3 ... BIOMOLECULE: 1, 2, 3 THIS ENTRY CONTAINS THE CRYSTALLOGRAPHIC ASYMMETRIC UNIT WHICH CONSISTS OF 3 CHAIN(S). SEE REMARK 350 FOR INFORMATION ON GENERATING THE BIOLOGICAL MOLECULE(S). ALTHOUGH THE THREE MOLECULES ARE RELATED TO ONE ANOTHER IN THE ASYMMETRIC UNIT BY NON-CRYSTALLOGRAPHIC 3-FOLD SYMMETRY, THE BIOLOGICAL UNIT IS A MONOMER.