Phosphorylation of CD3 and TCR zeta chains / Translocation of ZAP-70 to Immunological synapse / PD-1 signaling / Generation of second messenger molecules / Downstream TCR signaling / cytolysis / metabolic process / antigen processing and presentation of peptide antigen / MHC class II antigen presentation / positive regulation of T cell differentiation ...Phosphorylation of CD3 and TCR zeta chains / Translocation of ZAP-70 to Immunological synapse / PD-1 signaling / Generation of second messenger molecules / Downstream TCR signaling / cytolysis / metabolic process / antigen processing and presentation of peptide antigen / MHC class II antigen presentation / positive regulation of T cell differentiation / antigen processing and presentation / negative regulation of T cell proliferation / multivesicular body / peptide antigen assembly with MHC class II protein complex / MHC class II protein complex / peptide antigen binding / antigen processing and presentation of exogenous peptide antigen via MHC class II / positive regulation of immune response / positive regulation of T cell activation / lysozyme / MHC class II protein complex binding / lysozyme activity / late endosome membrane / adaptive immune response / early endosome / lysosome / defense response to bacterium / immune response / external side of plasma membrane / lysosomal membrane / protein-containing complex binding / Golgi apparatus / cell surface / extracellular region / membrane / plasma membrane 類似検索 - 分子機能
Lysozyme C / Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / MHC class II, beta chain, N-terminal / Class II histocompatibility antigen, beta domain / Class II histocompatibility antigen, beta domain / MHC class II, alpha chain, N-terminal / Class II histocompatibility antigen, alpha domain / Class II histocompatibility antigen, alpha domain / MHC class II, alpha/beta chain, N-terminal ...Lysozyme C / Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / MHC class II, beta chain, N-terminal / Class II histocompatibility antigen, beta domain / Class II histocompatibility antigen, beta domain / MHC class II, alpha chain, N-terminal / Class II histocompatibility antigen, alpha domain / Class II histocompatibility antigen, alpha domain / MHC class II, alpha/beta chain, N-terminal / Glycoside hydrolase, family 22, lysozyme / Glycoside hydrolase family 22 domain / Glycosyl hydrolases family 22 (GH22) domain signature. / Glycoside hydrolase, family 22 / C-type lysozyme/alpha-lactalbumin family / Glycosyl hydrolases family 22 (GH22) domain profile. / Alpha-lactalbumin / lysozyme C / MHC classes I/II-like antigen recognition protein / : / Lysozyme-like domain superfamily / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Roll / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly Beta / Alpha Beta 類似検索 - ドメイン・相同性
H-2 class II histocompatibility antigen, A-K alpha chain / H-2 class II histocompatibility antigen, A-K beta chain / Lysozyme C / Lysozyme 類似検索 - 構成要素
THIS ENTRY CONTAINS COORDINATES FOR THE EXTRACELLULAR DOMAINS OF THE MURINE MHC CLASS II MOLECULE I- ...THIS ENTRY CONTAINS COORDINATES FOR THE EXTRACELLULAR DOMAINS OF THE MURINE MHC CLASS II MOLECULE I-AK WITH A. PEPTIDE FROM HEN EGG WHITE LYSOZYME (50 - 62) COVALENTLY ATTACHED TO THE I-AK BETA CHAIN VIA A POLYPEPTIDE LINKER. THE HETERODIMER WAS EXPRESSED IN CHO CELLS AS A GPI-LINKED PROTEIN AND ENZYMATICALLY CLEAVED WITH PIPLC. FOR THE I-AK ALPHA CHAIN, THE FIRST 3 RESIDUES AND LAST 14 RESIDUES COULD NOT BE TRACED. FOR THE BETA CHAIN, 10 RESIDUES AMINO TERMINAL TO THE HEL PEPTIDE AND 16 RESIDUES IN THE COVALENT LINKER WERE DISORDERED, AS WERE 15 RESIDUES AT THE C-TERMINAL TAIL OF THE BETA CHAIN. THE FIRST TWO RESIDUES BUILT IN THE BETA CHAIN (GLY B5 AND SER B6) ARE IN FACT CLONING ARTIFACTS OF THE LINKER CONSTRUCTION, AS THESE RESIDUES ARE ARG B5 AND HIS B6 IN THE NATURAL I-AK SEQUENCE. THE HETEROATOM WATER 1 SITS AT A SPECIAL POSITION. ALL OTHER WATERS ARE NUMBERED IN ORDER OF THEIR TEMPERATURE FACTOR. HEL PEPTIDE RESIDUES 50-62 CORRESPOND TO BINDING SITES P-2 TO P11.