登録情報 データベース : PDB / ID : 1fu6 構造の表示 ダウンロードとリンクタイトル NMR STRUCTURE OF THE N-SH2 DOMAIN OF THE P85 SUBUNIT OF PI3-KINASE 要素PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT 詳細 キーワード PROTEIN BINDING / central beta-sheet with two flanking alpha-helices機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
PI3K events in ERBB4 signaling / Costimulation by the CD28 family / CD28 dependent PI3K/Akt signaling / MET activates PI3K/AKT signaling / Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / Interleukin receptor SHC signaling / Tie2 Signaling / Interleukin-3, Interleukin-5 and GM-CSF signaling / FLT3 Signaling / GAB1 signalosome ... PI3K events in ERBB4 signaling / Costimulation by the CD28 family / CD28 dependent PI3K/Akt signaling / MET activates PI3K/AKT signaling / Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / Interleukin receptor SHC signaling / Tie2 Signaling / Interleukin-3, Interleukin-5 and GM-CSF signaling / FLT3 Signaling / GAB1 signalosome / PI3K events in ERBB2 signaling / PI-3K cascade:FGFR1 / PI-3K cascade:FGFR3 / PI-3K cascade:FGFR4 / RHOJ GTPase cycle / RND2 GTPase cycle / RND1 GTPase cycle / IRS-mediated signalling / Interleukin-7 signaling / GP1b-IX-V activation signalling / Signaling by LTK / Synthesis of PIPs at the plasma membrane / PI3K/AKT activation / PI-3K cascade:FGFR2 / Regulation of signaling by CBL / Downstream TCR signaling / RHOF GTPase cycle / PI3K Cascade / VEGFA-VEGFR2 Pathway / Signaling by SCF-KIT / Role of LAT2/NTAL/LAB on calcium mobilization / RHOB GTPase cycle / CDC42 GTPase cycle / RHOD GTPase cycle / RND3 GTPase cycle / GPVI-mediated activation cascade / PIP3 activates AKT signaling / Downstream signal transduction / Signaling by ALK / RHOG GTPase cycle / Role of phospholipids in phagocytosis / RAC2 GTPase cycle / RHOU GTPase cycle / RHOV GTPase cycle / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / DAP12 signaling / RAC1 GTPase cycle / RET signaling / RHOA GTPase cycle / Extra-nuclear estrogen signaling / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / perinuclear endoplasmic reticulum membrane / response to yeast / regulation of toll-like receptor 4 signaling pathway / phosphatidylinositol metabolic process / negative regulation of muscle cell apoptotic process / phosphatidylinositol 3-kinase regulator activity / positive regulation of focal adhesion disassembly / response to fatty acid / interleukin-18-mediated signaling pathway / response to fructose / myeloid leukocyte migration / 1-phosphatidylinositol-3-kinase regulator activity / phosphatidylinositol 3-kinase regulatory subunit binding / neurotrophin TRKA receptor binding / response to growth factor / cis-Golgi network / ErbB-3 class receptor binding / negative regulation of cell adhesion / kinase activator activity / platelet-derived growth factor receptor binding / regulation of stress fiber assembly / positive regulation of endoplasmic reticulum unfolded protein response / phosphatidylinositol 3-kinase complex, class IA / G alpha (q) signalling events / positive regulation of synapse assembly / phosphatidylinositol 3-kinase complex / RAF/MAP kinase cascade / positive regulation of leukocyte migration / response to iron(II) ion / positive regulation of filopodium assembly / growth hormone receptor signaling pathway / negative regulation of stress fiber assembly / natural killer cell mediated cytotoxicity / cellular response to fatty acid / insulin binding / negative regulation of heart rate / 1-phosphatidylinositol-3-kinase activity / negative regulation of cell-matrix adhesion / negative regulation of cell-cell adhesion / response to testosterone / response to dexamethasone / intracellular glucose homeostasis / negative regulation of osteoclast differentiation / phosphatidylinositol phosphate biosynthetic process / insulin receptor substrate binding / extrinsic apoptotic signaling pathway via death domain receptors / positive regulation of myoblast differentiation / response to amino acid / regulation of protein localization to plasma membrane 類似検索 - 分子機能 Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain / PIK3R1, inter-SH2 domain / PI3K p85 subunit, C-terminal SH2 domain / PI3K regulatory subunit p85-related , inter-SH2 domain / PI3K p85 subunit, N-terminal SH2 domain / Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain / Rho GTPase-activating protein domain / RhoGAP domain / Rho GTPase-activating proteins domain profile. / GTPase-activator protein for Rho-like GTPases ... Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain / PIK3R1, inter-SH2 domain / PI3K p85 subunit, C-terminal SH2 domain / PI3K regulatory subunit p85-related , inter-SH2 domain / PI3K p85 subunit, N-terminal SH2 domain / Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain / Rho GTPase-activating protein domain / RhoGAP domain / Rho GTPase-activating proteins domain profile. / GTPase-activator protein for Rho-like GTPases / Rho GTPase activation protein / SH2 domain / SHC Adaptor Protein / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 Phosphatidylinositol 3-kinase regulatory subunit alpha 類似検索 - 構成要素生物種 Rattus norvegicus (ドブネズミ)手法 溶液NMR / The structures were energy minimized with MSI DISCOVER. 詳細データ登録者 Weber, T. / Schaffhausen, B. / Liu, Y. / Guenther, U.L. 引用ジャーナル : Biochemistry / 年 : 2000タイトル : NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site.著者 : Weber, T. / Schaffhausen, B. / Liu, Y. / Gunther, U.L. 履歴 登録 2000年9月14日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2001年2月21日 Provider : repository / タイプ : Initial release改定 1.1 2008年4月27日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2022年2月23日 Group : Data collection / Database references / Derived calculationsカテゴリ : database_2 / pdbx_nmr_software ... database_2 / pdbx_nmr_software / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _struct_ref_seq_dif.details 改定 1.4 2024年5月22日 Group : Data collection / カテゴリ : chem_comp_atom / chem_comp_bond
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