- PDB-2x18: The crystal structure of the PH domain of human AKT3 protein kinase -
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Basic information
Entry
Database: PDB / ID: 2x18
Title
The crystal structure of the PH domain of human AKT3 protein kinase
Components
RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE
Keywords
TRANSFERASE / KINASE / MEMBRANE / ATP-BINDING
Function / homology
Function and homology information
positive regulation of artery morphogenesis / AKT-mediated inactivation of FOXO1A / Negative regulation of the PI3K/AKT network / AKT phosphorylates targets in the nucleus / RUNX2 regulates genes involved in cell migration / mitochondrial genome maintenance / RAB GEFs exchange GTP for GDP on RABs / brain morphogenesis / AKT phosphorylates targets in the cytosol / positive regulation of vascular endothelial cell proliferation ...positive regulation of artery morphogenesis / AKT-mediated inactivation of FOXO1A / Negative regulation of the PI3K/AKT network / AKT phosphorylates targets in the nucleus / RUNX2 regulates genes involved in cell migration / mitochondrial genome maintenance / RAB GEFs exchange GTP for GDP on RABs / brain morphogenesis / AKT phosphorylates targets in the cytosol / positive regulation of vascular endothelial cell proliferation / Regulation of TP53 Activity through Association with Co-factors / positive regulation of cell migration involved in sprouting angiogenesis / CTLA4 inhibitory signaling / Constitutive Signaling by AKT1 E17K in Cancer / negative regulation of cellular senescence / CD28 dependent PI3K/Akt signaling / Regulation of localization of FOXO transcription factors / positive regulation of cell size / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / positive regulation of TOR signaling / Activation of BAD and translocation to mitochondria / positive regulation of blood vessel endothelial cell migration / Cyclin E associated events during G1/S transition / Cyclin A:Cdk2-associated events at S phase entry / homeostasis of number of cells within a tissue / Regulation of TP53 Activity through Acetylation / positive regulation of endothelial cell proliferation / Downregulation of ERBB2:ERBB3 signaling / VEGFR2 mediated vascular permeability / TP53 Regulates Metabolic Genes / Regulation of PTEN stability and activity / G beta:gamma signalling through PI3Kgamma / Regulation of TP53 Degradation / PIP3 activates AKT signaling / peptidyl-serine phosphorylation / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction / protein phosphorylation / protein serine/threonine kinase activity / signal transduction / ATP binding / membrane / nucleus / cytoplasm Similarity search - Function
Protein kinase B gamma, catalytic domain / Serine/threonine-protein kinase RAC gamma-like / Protein Kinase B, pleckstrin homology domain / Protein kinase, C-terminal / Protein kinase C terminal domain / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / PH-domain like / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. ...Protein kinase B gamma, catalytic domain / Serine/threonine-protein kinase RAC gamma-like / Protein Kinase B, pleckstrin homology domain / Protein kinase, C-terminal / Protein kinase C terminal domain / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / PH-domain like / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / PH-like domain superfamily / Roll / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Mainly Beta Similarity search - Domain/homology