|Entry||Database: PDB / ID: 1aiy|
|Title||R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 10 STRUCTURES|
|Components||(R6 INSULIN HEXAMER) x 2|
|Keywords||HORMONE / GLUCOSE METABOLISM|
|Function / homology|
Function and homology information
Synthesis, secretion, and deacylation of Ghrelin / Signaling by Insulin receptor / Regulation of insulin secretion / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / IRS activation / Signal attenuation / Insulin receptor signalling cascade / COPI-mediated anterograde transport / Regulation of gene expression in beta cells / Insulin processing ...Synthesis, secretion, and deacylation of Ghrelin / Signaling by Insulin receptor / Regulation of insulin secretion / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / IRS activation / Signal attenuation / Insulin receptor signalling cascade / COPI-mediated anterograde transport / Regulation of gene expression in beta cells / Insulin processing / Amyloid fiber formation / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / Insulin receptor recycling / negative regulation of glycogen catabolic process / alpha-beta T cell activation / negative regulation of fatty acid metabolic process / negative regulation of feeding behavior / negative regulation of NAD(P)H oxidase activity / positive regulation of respiratory burst / regulation of protein secretion / positive regulation of peptide hormone secretion / negative regulation of respiratory burst involved in inflammatory response / negative regulation of blood vessel diameter / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / positive regulation of lipid biosynthetic process / regulation of transmembrane transporter activity / positive regulation of dendritic spine maintenance / negative regulation of gluconeogenesis / negative regulation of reactive oxygen species biosynthetic process / negative regulation of lipid catabolic process / positive regulation of cellular protein metabolic process / negative regulation of protein secretion / negative regulation of protein oligomerization / fatty acid homeostasis / positive regulation of glycogen biosynthetic process / positive regulation of nitric oxide mediated signal transduction / positive regulation of glycolytic process / regulation of protein localization to plasma membrane / regulation of cellular amino acid metabolic process / transport vesicle / endoplasmic reticulum-Golgi intermediate compartment membrane / positive regulation of brown fat cell differentiation / endosome lumen / regulation of synaptic plasticity / cognition / positive regulation of protein autophosphorylation / neuron projection maintenance / positive regulation of insulin receptor signaling pathway / insulin-like growth factor receptor binding / positive regulation of cytokine secretion / positive regulation of mitotic nuclear division / negative regulation of acute inflammatory response / regulation of protein localization / positive regulation of cell differentiation / activation of protein kinase B activity / positive regulation of long-term synaptic potentiation / positive regulation of glucose import / positive regulation of blood vessel diameter / negative regulation of protein catabolic process / hormone activity / acute-phase response / negative regulation of proteolysis / insulin receptor signaling pathway / positive regulation of protein localization to nucleus / insulin receptor binding / positive regulation of nitric-oxide synthase activity / glucose metabolic process / Golgi lumen / wound healing / cell-cell signaling / glucose homeostasis / endoplasmic reticulum to Golgi vesicle-mediated transport / positive regulation of MAPK cascade / positive regulation of phosphatidylinositol 3-kinase signaling / positive regulation of cell growth / secretory granule lumen / protease binding / positive regulation of NF-kappaB transcription factor activity / positive regulation of cell migration / positive regulation of protein kinase B signaling / Golgi membrane / G protein-coupled receptor signaling pathway / endoplasmic reticulum lumen / regulation of transcription, DNA-templated / cellular protein metabolic process / positive regulation of gene expression / positive regulation of cell population proliferation / extracellular space / extracellular region / identical protein binding
Insulin / Insulin-like / Insulin family / Insulin, conserved site / Insulin/IGF/Relaxin family / Insulin-like superfamily / Insulin family signature.
|Biological species||Homo sapiens (human)|
|Method||SOLUTION NMR / DISTANCE GEOMETRY, SIMULATED ANNEALING, ENERGY MINIMIZATION|
|Authors||Chang, X. / Jorgensen, A.M.M. / Bardrum, P. / Led, J.J.|
|Citation||Journal: Biochemistry / Year: 1997|
Title: Solution structures of the R6 human insulin hexamer.
Authors: Chang, X. / Jorgensen, A.M. / Bardrum, P. / Led, J.J.
SummaryFull reportAbout validation report
|Date||Deposition: Apr 30, 1997 / Release: Nov 12, 1997|
|Structure viewer||Molecule: |
Downloads & links
A: R6 INSULIN HEXAMER
B: R6 INSULIN HEXAMER
C: R6 INSULIN HEXAMER
D: R6 INSULIN HEXAMER
E: R6 INSULIN HEXAMER
F: R6 INSULIN HEXAMER
G: R6 INSULIN HEXAMER
H: R6 INSULIN HEXAMER
I: R6 INSULIN HEXAMER
J: R6 INSULIN HEXAMER
K: R6 INSULIN HEXAMER
L: R6 INSULIN HEXAMER
Mass: 2383.698 Da / Num. of mol.: 6 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / Organ: PANCREAS / References: UniProt: P01308
Mass: 3433.953 Da / Num. of mol.: 6 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / Organ: PANCREAS / References: UniProt: P01308
|#3: Chemical||#4: Chemical|
|#5: Water|| ChemComp-HOH / |
|Experiment||Method: SOLUTION NMR|
Conditions-ID: 1 / Solution-ID: 1
|Sample conditions||pH: 8.0 / Temperature: 310 K|
*PLUSMethod: other / Details: NMR
|Refinement||Method: DISTANCE GEOMETRY, SIMULATED ANNEALING, ENERGY MINIMIZATION|
Software ordinal: 1
|NMR ensemble||Conformer selection criteria: LOWEST TOTAL ENERGY / Conformers calculated total number: 30 / Conformers submitted total number: 10|
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