登録情報 | データベース: EMDB / ID: EMD-43782 |
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タイトル | Rat GluN1-GluN2B NMDA receptor channel in complex with glycine |
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マップデータ | The B-factor sharpened map. |
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試料 | - 複合体: Di-heterotetrameric GluN1-GluN2B NMDA receptors
- タンパク質・ペプチド: Isoform B of Glutamate receptor ionotropic, NMDA 1
- タンパク質・ペプチド: Glutamate receptor ionotropic, NMDA 2B
- リガンド: GLYCINE
- リガンド: 2-acetamido-2-deoxy-beta-D-glucopyranose
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キーワード | Ligand-gated ion channel / ionotropic glutamate receptor / synaptic membrane protein / MEMBRANE PROTEIN |
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機能・相同性 | 機能・相同性情報
neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential / cellular response to curcumin / cellular response to corticosterone stimulus / cellular response to magnesium starvation / regulation of postsynaptic cytosolic calcium ion concentration / sensory organ development / sensitization / pons maturation / regulation of cell communication / positive regulation of Schwann cell migration ...neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential / cellular response to curcumin / cellular response to corticosterone stimulus / cellular response to magnesium starvation / regulation of postsynaptic cytosolic calcium ion concentration / sensory organ development / sensitization / pons maturation / regulation of cell communication / positive regulation of Schwann cell migration / EPHB-mediated forward signaling / neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration / response to hydrogen sulfide / Assembly and cell surface presentation of NMDA receptors / olfactory learning / regulation of protein kinase A signaling / conditioned taste aversion / dendritic branch / response to other organism / regulation of respiratory gaseous exchange / protein localization to postsynaptic membrane / positive regulation of inhibitory postsynaptic potential / apical dendrite / propylene metabolic process / response to glycine / regulation of ARF protein signal transduction / fear response / response to methylmercury / positive regulation of cysteine-type endopeptidase activity / voltage-gated monoatomic cation channel activity / cellular response to dsRNA / response to carbohydrate / negative regulation of dendritic spine maintenance / regulation of monoatomic cation transmembrane transport / interleukin-1 receptor binding / cellular response to lipid / response to morphine / NMDA glutamate receptor activity / positive regulation of glutamate secretion / response to growth hormone / Synaptic adhesion-like molecules / NMDA selective glutamate receptor complex / RAF/MAP kinase cascade / parallel fiber to Purkinje cell synapse / NMDA selective glutamate receptor signaling pathway / response to manganese ion / calcium ion transmembrane import into cytosol / glutamate binding / neuromuscular process / positive regulation of reactive oxygen species biosynthetic process / protein heterotetramerization / regulation of synapse assembly / glycine binding / positive regulation of calcium ion transport into cytosol / regulation of dendrite morphogenesis / regulation of axonogenesis / male mating behavior / heterocyclic compound binding / action potential / suckling behavior / behavioral response to pain / startle response / response to amine / receptor clustering / monoatomic cation transmembrane transport / regulation of neuronal synaptic plasticity / monoatomic cation transport / associative learning / positive regulation of excitatory postsynaptic potential / regulation of MAPK cascade / social behavior / response to magnesium ion / ligand-gated monoatomic ion channel activity / cellular response to organic cyclic compound / excitatory synapse / extracellularly glutamate-gated ion channel activity / cellular response to glycine / positive regulation of dendritic spine maintenance / small molecule binding / neuron development / behavioral fear response / regulation of postsynaptic membrane potential / Unblocking of NMDA receptors, glutamate binding and activation / postsynaptic density, intracellular component / phosphatase binding / cellular response to manganese ion / glutamate-gated calcium ion channel activity / calcium ion homeostasis / glutamate receptor binding / D2 dopamine receptor binding / multicellular organismal response to stress / prepulse inhibition / monoatomic cation channel activity / long-term memory / detection of mechanical stimulus involved in sensory perception of pain / regulation of neuron apoptotic process / response to electrical stimulus / synaptic cleft / response to mechanical stimulus / glutamate-gated receptor activity類似検索 - 分子機能 Glutamate [NMDA] receptor, epsilon subunit, C-terminal / N-methyl D-aspartate receptor 2B3 C-terminus / : / : / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / Ligand-gated ion channel ...Glutamate [NMDA] receptor, epsilon subunit, C-terminal / N-methyl D-aspartate receptor 2B3 C-terminus / : / : / Bacterial extracellular solute-binding proteins, family 3 / Solute-binding protein family 3/N-terminal domain of MltF / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / : / Ligand-gated ion channel / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Ionotropic glutamate receptor / Eukaryotic homologues of bacterial periplasmic substrate binding proteins. / Receptor, ligand binding region / Receptor family ligand binding region / Periplasmic binding protein-like I類似検索 - ドメイン・相同性 Glutamate receptor ionotropic, NMDA 1 / Glutamate receptor ionotropic, NMDA 2B類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Rattus norvegicus (ドブネズミ) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.69 Å |
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データ登録者 | Chou T-H / Furukawa H |
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資金援助 | 米国, 2件 Organization | Grant number | 国 |
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National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) | NS111745 | 米国 | National Institutes of Health/National Institute of Mental Health (NIH/NIMH) | MH085926 | 米国 |
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引用 | ジャーナル: To Be Published タイトル: Molecular mechanism of ligand-gating in NMDA receptor channel 著者: Chou T-H / Furukawa H |
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履歴 | 登録 | 2024年2月23日 | - |
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ヘッダ(付随情報) 公開 | 2024年7月31日 | - |
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マップ公開 | 2024年7月31日 | - |
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更新 | 2024年7月31日 | - |
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現状 | 2024年7月31日 | 処理サイト: RCSB / 状態: 公開 |
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