+Open data
-Basic information
Entry | Database: PDB / ID: 7l9a | ||||||
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Title | Crystal structure of BRDT bromodomain 2 in complex with CDD-1102 | ||||||
Components | Bromodomain testis-specific protein | ||||||
Keywords | TRANSCRIPTION/INHIBITOR / TRANSCRIPTION-INHIBITOR complex | ||||||
Function / homology | Function and homology information sperm DNA condensation / male meiotic nuclear division / male meiosis I / regulation of RNA splicing / histone reader activity / RNA splicing / lysine-acetylated histone binding / mRNA processing / histone binding / transcription coactivator activity ...sperm DNA condensation / male meiotic nuclear division / male meiosis I / regulation of RNA splicing / histone reader activity / RNA splicing / lysine-acetylated histone binding / mRNA processing / histone binding / transcription coactivator activity / chromatin remodeling / regulation of DNA-templated transcription / positive regulation of gene expression / nucleus Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.27 Å | ||||||
Authors | Sharma, R. / Kaur, G. / Yu, Z. / Ku, A.F. / Anglin, J.L. / Ucisik, M.N. / Faver, J.C. / Sankaran, B. / Kim, C. / Matzuk, M.M. | ||||||
Funding support | United States, 1items
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Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2021 Title: Discovery and characterization of bromodomain 2-specific inhibitors of BRDT. Authors: Yu, Z. / Ku, A.F. / Anglin, J.L. / Sharma, R. / Ucisik, M.N. / Faver, J.C. / Li, F. / Nyshadham, P. / Simmons, N. / Sharma, K.L. / Nagarajan, S. / Riehle, K. / Kaur, G. / Sankaran, B. / ...Authors: Yu, Z. / Ku, A.F. / Anglin, J.L. / Sharma, R. / Ucisik, M.N. / Faver, J.C. / Li, F. / Nyshadham, P. / Simmons, N. / Sharma, K.L. / Nagarajan, S. / Riehle, K. / Kaur, G. / Sankaran, B. / Storl-Desmond, M. / Palmer, S.S. / Young, D.W. / Kim, C. / Matzuk, M.M. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7l9a.cif.gz | 136.3 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7l9a.ent.gz | 87.9 KB | Display | PDB format |
PDBx/mmJSON format | 7l9a.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/l9/7l9a ftp://data.pdbj.org/pub/pdb/validation_reports/l9/7l9a | HTTPS FTP |
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-Related structure data
Related structure data | 7l99C 4uygS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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2 |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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