Entry Database : PDB / ID : 7l99 Structure visualization Downloads & linksTitle Crystal structure of BRDT bromodomain 2 in complex with CDD-1302 ComponentsBromodomain testis-specific protein Details Keywords TRANSCRIPTION / Inhibitor ComplexFunction / homology Function and homology informationFunction Domain/homology Component
sperm DNA condensation / male meiotic nuclear division / male meiosis I / regulation of RNA splicing / localization / histone reader activity / RNA splicing / lysine-acetylated histone binding / mRNA processing / histone binding ... sperm DNA condensation / male meiotic nuclear division / male meiosis I / regulation of RNA splicing / localization / histone reader activity / RNA splicing / lysine-acetylated histone binding / mRNA processing / histone binding / transcription coactivator activity / chromatin remodeling / positive regulation of gene expression / regulation of DNA-templated transcription / chromatin / nucleus Similarity search - Function Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. ... Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.9 Å DetailsAuthors Sharma, R. / Yu, Z. / Ku, A.F. / Anglin, J.L. / Ucisik, M.N. / Faver, J.C. / Sankaran, B. / Kim, C. / Matzuk, M.M. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD) P01HD087157 United States
CitationJournal : Proc.Natl.Acad.Sci.USA / Year : 2021Title : Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.Authors: Yu, Z. / Ku, A.F. / Anglin, J.L. / Sharma, R. / Ucisik, M.N. / Faver, J.C. / Li, F. / Nyshadham, P. / Simmons, N. / Sharma, K.L. / Nagarajan, S. / Riehle, K. / Kaur, G. / Sankaran, B. / ... Authors : Yu, Z. / Ku, A.F. / Anglin, J.L. / Sharma, R. / Ucisik, M.N. / Faver, J.C. / Li, F. / Nyshadham, P. / Simmons, N. / Sharma, K.L. / Nagarajan, S. / Riehle, K. / Kaur, G. / Sankaran, B. / Storl-Desmond, M. / Palmer, S.S. / Young, D.W. / Kim, C. / Matzuk, M.M. History Deposition Jan 3, 2021 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 30, 2021 Provider : repository / Type : Initial releaseRevision 1.1 Oct 18, 2023 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Show all Show less