Entry Database : PDB / ID : 4uyg Structure visualization Downloads & linksTitle C-Terminal bromodomain of Human BRD2 with I-BET726 (GSK1324726A) ComponentsBROMODOMAIN-CONTAINING PROTEIN 2 Details Keywords TRANSCRIPTION / INHIBITOR / HISTONE / EPIGENETIC READER / BET / BRD2Function / homology Function and homology informationFunction Domain/homology Component
acetylation-dependent protein binding / chromatin looping / RUNX3 regulates p14-ARF / positive regulation of T-helper 17 cell lineage commitment / protein localization to chromatin / neural tube closure / lysine-acetylated histone binding / nucleosome assembly / spermatogenesis / nuclear speck ... acetylation-dependent protein binding / chromatin looping / RUNX3 regulates p14-ARF / positive regulation of T-helper 17 cell lineage commitment / protein localization to chromatin / neural tube closure / lysine-acetylated histone binding / nucleosome assembly / spermatogenesis / nuclear speck / protein phosphorylation / protein serine/threonine kinase activity / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytoplasm Similarity search - Function NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. ... NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.5 Å DetailsAuthors Chung, C. / Bamborough, P. / Gosmini, R. CitationJournal : J.Med.Chem. / Year : 2014Title : The Discovery of I-Bet726 (Gsk1324726A), a Potent Tetrahydroquinoline Apoa1 Up-Regulator and Selective Bet Bromodomain Inhibitor.Authors: Gosmini, R. / Nguyen, V.L. / Toum, J. / Simon, C. / Brusq, J.M. / Krysa, G. / Mirguet, O. / Riou-Eymard, A.M. / Boursier, E.V. / Trottet, L. / Bamborough, P. / Clark, H. / Chung, C.W. / ... Authors : Gosmini, R. / Nguyen, V.L. / Toum, J. / Simon, C. / Brusq, J.M. / Krysa, G. / Mirguet, O. / Riou-Eymard, A.M. / Boursier, E.V. / Trottet, L. / Bamborough, P. / Clark, H. / Chung, C.W. / Cutler, L. / Demont, E.H. / Kaur, R. / Lewis, A.J. / Schilling, M.B. / Soden, P.E. / Taylor, S. / Walker, A.L. / Walker, M.D. / Prinjha, R.K. / Nicodeme, E. History Deposition Aug 31, 2014 Deposition site : PDBE / Processing site : PDBERevision 1.0 Oct 8, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Oct 22, 2014 Group : Database referencesRevision 1.2 May 8, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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