Entry | Database: PDB / ID: 4uye |
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Title | BROMODOMAIN OF HUMAN BRPF1 WITH N-1,3-dimethyl-2-oxo-6-(piperidin-1- yl)-2,3-dihydro-1H-1,3-benzodiazol-5-yl-2-methoxybenzamide |
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Components | PEREGRIN |
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Keywords | TRANSCRIPTION / INHIBITOR / HISTONE / EPIGENETIC READER / ANTAGONIST |
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Function / homology | Function and homology information
acetyltransferase activator activity / regulation of developmental process / regulation of hemopoiesis / MOZ/MORF histone acetyltransferase complex / histone acetyltransferase complex / Regulation of TP53 Activity through Acetylation / HATs acetylate histones / chromatin remodeling / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription ...acetyltransferase activator activity / regulation of developmental process / regulation of hemopoiesis / MOZ/MORF histone acetyltransferase complex / histone acetyltransferase complex / Regulation of TP53 Activity through Acetylation / HATs acetylate histones / chromatin remodeling / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / regulation of DNA-templated transcription / DNA binding / nucleoplasm / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosolSimilarity search - Function BRPF1, PHD domain / Peregrin, ePHD domain / : / : / Enhancer of polycomb-like, N-terminal / Enhancer of polycomb-like / PHD-finger / PHD-zinc-finger like domain / Extended PHD (ePHD) domain / Extended PHD (ePHD) domain profile. ...BRPF1, PHD domain / Peregrin, ePHD domain / : / : / Enhancer of polycomb-like, N-terminal / Enhancer of polycomb-like / PHD-finger / PHD-zinc-finger like domain / Extended PHD (ePHD) domain / Extended PHD (ePHD) domain profile. / domain with conserved PWWP motif / PWWP domain / PWWP domain profile. / PWWP domain / Zinc finger C2H2 type domain profile. / Zinc finger, PHD-type, conserved site / Zinc finger C2H2 type domain signature. / Zinc finger PHD-type signature. / Zinc finger C2H2-type / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Zinc finger, FYVE/PHD-type / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Bromodomain / Zinc finger, RING/FYVE/PHD-type / Up-down Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | HOMO SAPIENS (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.65 Å |
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Authors | Chung, C. / Bamborough, P. / Demont, E. |
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Citation | Journal: Acs Med.Chem.Lett. / Year: 2014 Title: 1,3-Dimethyl Benzimidazolones are Potent, Selective Inhibitors of the Brpf1 Bromodomain. Authors: Demont, E.H. / Bamborough, P. / Chung, C.W. / Craggs, P.D. / Fallon, D. / Gordon, L.J. / Grandi, P. / Hobbs, C.I. / Hussain, J. / Jones, E.J. / Le Gall, A. / Michon, A.M. / Mitchell, D.J. / ...Authors: Demont, E.H. / Bamborough, P. / Chung, C.W. / Craggs, P.D. / Fallon, D. / Gordon, L.J. / Grandi, P. / Hobbs, C.I. / Hussain, J. / Jones, E.J. / Le Gall, A. / Michon, A.M. / Mitchell, D.J. / Prinjha, R.K. / Roberts, A.D. / Sheppard, R.J. / Watson, R.J. |
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History | Deposition | Aug 30, 2014 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Sep 17, 2014 | Provider: repository / Type: Initial release |
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Revision 1.1 | Dec 3, 2014 | Group: Database references |
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Revision 1.2 | May 8, 2024 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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