Entry Database : PDB / ID : 5zwh Structure visualization Downloads & linksTitle Covalent bond formation between histidine of Vitamin D receptor (VDR) and a full agonist having an ene-ynone group via conjugate addition reaction Components13-meric peptide from DRIP205 NR2 BOX peptide Vitamin D3 receptor DetailsKeywords HORMONE / HORMONE covalent modifier transcription factor VitaminD3 enone Michael addition electrophileFunction / homology Function and homology informationFunction Domain/homology Component
enucleate erythrocyte development / negative regulation of bone trabecula formation / positive regulation of type II interferon-mediated signaling pathway / Vitamin D (calciferol) metabolism / regulation of RNA biosynthetic process / androgen biosynthetic process / positive regulation of G0 to G1 transition / retinal pigment epithelium development / mammary gland branching involved in thelarche / SUMOylation of intracellular receptors ... enucleate erythrocyte development / negative regulation of bone trabecula formation / positive regulation of type II interferon-mediated signaling pathway / Vitamin D (calciferol) metabolism / regulation of RNA biosynthetic process / androgen biosynthetic process / positive regulation of G0 to G1 transition / retinal pigment epithelium development / mammary gland branching involved in thelarche / SUMOylation of intracellular receptors / G0 to G1 transition / thyroid hormone receptor signaling pathway / Nuclear Receptor transcription pathway / bile acid nuclear receptor activity / response to bile acid / dense fibrillar component / core mediator complex / positive regulation of parathyroid hormone secretion / regulation of vitamin D receptor signaling pathway / apoptotic process involved in mammary gland involution / phosphate ion transmembrane transport / cellular response to vitamin D / positive regulation of apoptotic process involved in mammary gland involution / vitamin D binding / calcitriol binding / LBD domain binding / lithocholic acid binding / ventricular trabecula myocardium morphogenesis / thyroid hormone generation / mediator complex / nuclear retinoic acid receptor binding / positive regulation of keratinocyte differentiation / Generic Transcription Pathway / embryonic heart tube development / cellular response to thyroid hormone stimulus / negative regulation of ossification / monocyte differentiation / positive regulation of hepatocyte proliferation / embryonic hindlimb morphogenesis / vitamin D receptor signaling pathway / peroxisome proliferator activated receptor binding / positive regulation of vitamin D receptor signaling pathway / nuclear vitamin D receptor binding / bile acid signaling pathway / intestinal absorption / lens development in camera-type eye / nuclear thyroid hormone receptor binding / positive regulation of intracellular estrogen receptor signaling pathway / embryonic hemopoiesis / embryonic placenta development / megakaryocyte development / cellular response to steroid hormone stimulus / histone acetyltransferase binding / cellular response to hepatocyte growth factor stimulus / response to aldosterone / RSV-host interactions / epithelial cell proliferation involved in mammary gland duct elongation / fat cell differentiation / mammary gland branching involved in pregnancy / regulation of calcium ion transport / nuclear retinoid X receptor binding / decidualization / general transcription initiation factor binding / cellular response to epidermal growth factor stimulus / negative regulation of neuron differentiation / hematopoietic stem cell differentiation / negative regulation of keratinocyte proliferation / positive regulation of transcription initiation by RNA polymerase II / peroxisome proliferator activated receptor signaling pathway / animal organ regeneration / heterochromatin / erythrocyte development / positive regulation of transcription elongation by RNA polymerase II / nuclear receptor-mediated steroid hormone signaling pathway / ubiquitin ligase complex / RNA polymerase II preinitiation complex assembly / keratinocyte differentiation / transcription coregulator activity / T-tubule / RORA activates gene expression / lactation / Regulation of lipid metabolism by PPARalpha / BMAL1:CLOCK,NPAS2 activates circadian gene expression / positive regulation of erythrocyte differentiation / Activation of gene expression by SREBF (SREBP) / liver development / nuclear receptor coactivator activity / skeletal system development / mRNA transcription by RNA polymerase II / nuclear receptor binding / promoter-specific chromatin binding / nuclear estrogen receptor binding / apoptotic signaling pathway / animal organ morphogenesis / PPARA activates gene expression / Heme signaling / response to calcium ion / Nuclear Receptor transcription pathway / euchromatin / brain development Similarity search - Function : / Mediator complex, subunit Med1 / Mediator of RNA polymerase II transcription subunit 1 / Vitamin D receptor / VDR, DNA-binding domain / : / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. ... : / Mediator complex, subunit Med1 / Mediator of RNA polymerase II transcription subunit 1 / Vitamin D receptor / VDR, DNA-binding domain / : / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Ligand-binding domain of nuclear hormone receptor / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 2.38 Å DetailsAuthors Yoshizawa, M. / Itoh, T. / Anami, Y. / Kato, A. / Yoshimoto, N. / Yamamoto, K. Funding support Japan, 1items Details Hide detailsOrganization Grant number Country Japan
CitationJournal : J. Med. Chem. / Year : 2018Title : Identification of the Histidine Residue in Vitamin D Receptor That Covalently Binds to Electrophilic LigandsAuthors : Yoshizawa, M. / Itoh, T. / Hori, T. / Kato, A. / Anami, Y. / Yoshimoto, N. / Yamamoto, K. History Deposition May 15, 2018 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jul 18, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Aug 8, 2018 Group : Data collection / Database references / Category : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.identifier_ORCID
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