登録情報 データベース : PDB / ID : 5hxb 構造の表示 ダウンロードとリンクタイトル Cereblon in complex with DDB1, CC-885, and GSPT1 要素DNA damage-binding protein 1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Protein cereblon 詳細キーワード LIGASE / E3 / ubiquitin / DCAF / cereblon / DDB1 / CRL4 / cullin / IMiD / GSPT1 / CRBN機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
translation release factor complex / negative regulation of monoatomic ion transmembrane transport / translation release factor activity / regulation of translational termination / positive regulation by virus of viral protein levels in host cell / protein methylation / epigenetic programming in the zygotic pronuclei / spindle assembly involved in female meiosis / Cul4-RING E3 ubiquitin ligase complex / UV-damage excision repair ... translation release factor complex / negative regulation of monoatomic ion transmembrane transport / translation release factor activity / regulation of translational termination / positive regulation by virus of viral protein levels in host cell / protein methylation / epigenetic programming in the zygotic pronuclei / spindle assembly involved in female meiosis / Cul4-RING E3 ubiquitin ligase complex / UV-damage excision repair / biological process involved in interaction with symbiont / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / WD40-repeat domain binding / regulation of mitotic cell cycle phase transition / Cul4A-RING E3 ubiquitin ligase complex / Cul4B-RING E3 ubiquitin ligase complex / ubiquitin ligase complex scaffold activity / negative regulation of reproductive process / negative regulation of developmental process / locomotory exploration behavior / cullin family protein binding / Eukaryotic Translation Termination / viral release from host cell / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / positive regulation of Wnt signaling pathway / ectopic germ cell programmed cell death / proteasomal protein catabolic process / negative regulation of protein-containing complex assembly / positive regulation of viral genome replication / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / cytosolic ribosome / translational termination / positive regulation of gluconeogenesis / nucleotide-excision repair / Recognition of DNA damage by PCNA-containing replication complex / 加水分解酵素; 酸無水物に作用; GTPに作用・細胞または細胞小器官の運動に関与 / DNA Damage Recognition in GG-NER / positive regulation of protein-containing complex assembly / regulation of circadian rhythm / Dual Incision in GG-NER / Transcription-Coupled Nucleotide Excision Repair (TC-NER) / Formation of TC-NER Pre-Incision Complex / Wnt signaling pathway / Regulation of expression of SLITs and ROBOs / Formation of Incision Complex in GG-NER / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / G1/S transition of mitotic cell cycle / positive regulation of protein catabolic process / cellular response to UV / rhythmic process / protein-macromolecule adaptor activity / Neddylation / site of double-strand break / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / transmembrane transporter binding / Potential therapeutics for SARS / chromosome, telomeric region / damaged DNA binding / protein ubiquitination / translation / DNA repair / GTPase activity / apoptotic process / DNA damage response / protein-containing complex binding / nucleolus / GTP binding / negative regulation of apoptotic process / perinuclear region of cytoplasm / protein-containing complex / DNA binding / RNA binding / extracellular space / extracellular exosome / nucleoplasm / membrane / nucleus / metal ion binding / cytoplasm / cytosol 類似検索 - 分子機能 Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #1480 / LON domain-like / Peptide methionine sulfoxide reductase. / DNA polymerase; domain 1 - #910 / Yippee/Mis18/Cereblon / Yippee zinc-binding/DNA-binding /Mis18, centromere assembly / Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A / Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 / CULT domain / CULT domain profile. ... Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #1480 / LON domain-like / Peptide methionine sulfoxide reductase. / DNA polymerase; domain 1 - #910 / Yippee/Mis18/Cereblon / Yippee zinc-binding/DNA-binding /Mis18, centromere assembly / Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A / Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 / CULT domain / CULT domain profile. / Lon protease, N-terminal domain superfamily / Lon N-terminal domain profile. / Lon protease, N-terminal domain / ATP-dependent protease La (LON) substrate-binding domain / Found in ATP-dependent protease La (LON) / Translation elongation factor EFTu/EF1A, C-terminal / Elongation factor Tu C-terminal domain / Cleavage/polyadenylation specificity factor, A subunit, N-terminal / Mono-functional DNA-alkylating methyl methanesulfonate N-term / Cleavage/polyadenylation specificity factor, A subunit, C-terminal / CPSF A subunit region / Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal / PUA-like superfamily / Translation factors / Tr-type G domain, conserved site / Translational (tr)-type guanine nucleotide-binding (G) domain signature. / YVTN repeat-like/Quinoprotein amine dehydrogenase / Translation elongation factor EFTu-like, domain 2 / 7 Propeller / Methylamine Dehydrogenase; Chain H / Elongation factor Tu domain 2 / Elongation Factor Tu (Ef-tu); domain 3 / Translational (tr)-type GTP-binding domain / Elongation factor Tu GTP binding domain / Translational (tr)-type guanine nucleotide-binding (G) domain profile. / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / Beta Complex / DNA polymerase; domain 1 / Translation protein, beta-barrel domain superfamily / Roll / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / Up-down Bundle / Beta Barrel / P-loop containing nucleoside triphosphate hydrolase / Orthogonal Bundle / Mainly Beta / Mainly Alpha 類似検索 - ドメイン・相同性 Chem-85C / Eukaryotic peptide chain release factor GTP-binding subunit ERF3A / DNA damage-binding protein 1 / Protein cereblon 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.6 Å 詳細データ登録者 Chamberlain, P.P. / Matyskiela, M. / Pagarigan, B. 引用ジャーナル : Nature / 年 : 2016タイトル : A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.著者: Matyskiela, M.E. / Lu, G. / Ito, T. / Pagarigan, B. / Lu, C.C. / Miller, K. / Fang, W. / Wang, N.Y. / Nguyen, D. / Houston, J. / Carmel, G. / Tran, T. / Riley, M. / Nosaka, L. / Lander, G.C. ... 著者 : Matyskiela, M.E. / Lu, G. / Ito, T. / Pagarigan, B. / Lu, C.C. / Miller, K. / Fang, W. / Wang, N.Y. / Nguyen, D. / Houston, J. / Carmel, G. / Tran, T. / Riley, M. / Nosaka, L. / Lander, G.C. / Gaidarova, S. / Xu, S. / Ruchelman, A.L. / Handa, H. / Carmichael, J. / Daniel, T.O. / Cathers, B.E. / Lopez-Girona, A. / Chamberlain, P.P. 履歴 登録 2016年1月30日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2016年6月29日 Provider : repository / タイプ : Initial release改定 1.1 2016年7月6日 Group : Database references改定 1.2 2016年7月27日 Group : Database references改定 1.3 2017年11月1日 Group : Advisory / Author supporting evidence ... Advisory / Author supporting evidence / Database references / Derived calculations カテゴリ : citation / pdbx_struct_assembly_auth_evidence ... citation / pdbx_struct_assembly_auth_evidence / pdbx_struct_oper_list / pdbx_unobs_or_zero_occ_atoms Item : _citation.journal_id_CSD / _pdbx_struct_oper_list.symmetry_operation改定 1.4 2023年9月27日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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