Entry Database : PDB / ID : 5hxb Structure visualization Downloads & linksTitle Cereblon in complex with DDB1, CC-885, and GSPT1 ComponentsDNA damage-binding protein 1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Protein cereblon DetailsKeywords LIGASE / E3 / ubiquitin / DCAF / cereblon / DDB1 / CRL4 / cullin / IMiD / GSPT1 / CRBNFunction / homology Function and homology informationFunction Domain/homology Component
translation release factor complex / negative regulation of monoatomic ion transmembrane transport / translation release factor activity / regulation of translational termination / positive regulation by virus of viral protein levels in host cell / protein methylation / epigenetic programming in the zygotic pronuclei / spindle assembly involved in female meiosis / Cul4-RING E3 ubiquitin ligase complex / UV-damage excision repair ... translation release factor complex / negative regulation of monoatomic ion transmembrane transport / translation release factor activity / regulation of translational termination / positive regulation by virus of viral protein levels in host cell / protein methylation / epigenetic programming in the zygotic pronuclei / spindle assembly involved in female meiosis / Cul4-RING E3 ubiquitin ligase complex / UV-damage excision repair / biological process involved in interaction with symbiont / regulation of mitotic cell cycle phase transition / Cul4A-RING E3 ubiquitin ligase complex / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / WD40-repeat domain binding / ubiquitin ligase complex scaffold activity / Cul4B-RING E3 ubiquitin ligase complex / negative regulation of reproductive process / negative regulation of developmental process / locomotory exploration behavior / cullin family protein binding / Eukaryotic Translation Termination / viral release from host cell / positive regulation of Wnt signaling pathway / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / ectopic germ cell programmed cell death / proteasomal protein catabolic process / negative regulation of protein-containing complex assembly / positive regulation of viral genome replication / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / translational termination / cytosolic ribosome / positive regulation of gluconeogenesis / regulation of circadian rhythm / nucleotide-excision repair / Recognition of DNA damage by PCNA-containing replication complex / Hydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement / DNA Damage Recognition in GG-NER / positive regulation of protein-containing complex assembly / Transcription-Coupled Nucleotide Excision Repair (TC-NER) / G1/S transition of mitotic cell cycle / Formation of TC-NER Pre-Incision Complex / Dual Incision in GG-NER / Wnt signaling pathway / Regulation of expression of SLITs and ROBOs / Formation of Incision Complex in GG-NER / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / positive regulation of protein catabolic process / rhythmic process / cellular response to UV / Neddylation / protein-macromolecule adaptor activity / site of double-strand break / chromosome, telomeric region / ubiquitin-dependent protein catabolic process / Potential therapeutics for SARS / proteasome-mediated ubiquitin-dependent protein catabolic process / transmembrane transporter binding / damaged DNA binding / protein ubiquitination / translation / DNA repair / GTPase activity / DNA damage response / negative regulation of apoptotic process / protein-containing complex binding / nucleolus / GTP binding / apoptotic process / perinuclear region of cytoplasm / protein-containing complex / DNA binding / RNA binding / extracellular space / extracellular exosome / nucleoplasm / membrane / nucleus / metal ion binding / cytoplasm / cytosol Similarity search - Function Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #1480 / LON domain-like / Peptide methionine sulfoxide reductase. / DNA polymerase; domain 1 - #910 / Yippee/Mis18/Cereblon / Yippee zinc-binding/DNA-binding /Mis18, centromere assembly / Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A / Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 / : / CULT domain ... Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #1480 / LON domain-like / Peptide methionine sulfoxide reductase. / DNA polymerase; domain 1 - #910 / Yippee/Mis18/Cereblon / Yippee zinc-binding/DNA-binding /Mis18, centromere assembly / Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A / Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4 / : / CULT domain / CULT domain profile. / Lon protease, N-terminal domain superfamily / Lon N-terminal domain profile. / Lon protease, N-terminal domain / ATP-dependent protease La (LON) substrate-binding domain / Found in ATP-dependent protease La (LON) / Translation elongation factor EFTu/EF1A, C-terminal / Elongation factor Tu C-terminal domain / Cleavage/polyadenylation specificity factor, A subunit, N-terminal / Mono-functional DNA-alkylating methyl methanesulfonate N-term / : / Cleavage/polyadenylation specificity factor, A subunit, C-terminal / CPSF A subunit region / Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal / Translation factors / PUA-like superfamily / Tr-type G domain, conserved site / Translational (tr)-type guanine nucleotide-binding (G) domain signature. / YVTN repeat-like/Quinoprotein amine dehydrogenase / Translation elongation factor EFTu-like, domain 2 / 7 Propeller / Methylamine Dehydrogenase; Chain H / Elongation factor Tu domain 2 / Elongation Factor Tu (Ef-tu); domain 3 / Translational (tr)-type GTP-binding domain / Elongation factor Tu GTP binding domain / Translational (tr)-type guanine nucleotide-binding (G) domain profile. / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / Beta Complex / DNA polymerase; domain 1 / Translation protein, beta-barrel domain superfamily / Roll / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / Up-down Bundle / Beta Barrel / P-loop containing nucleoside triphosphate hydrolase / Orthogonal Bundle / Mainly Beta / Mainly Alpha Similarity search - Domain/homology Chem-85C / Eukaryotic peptide chain release factor GTP-binding subunit ERF3A / DNA damage-binding protein 1 / Protein cereblon Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.6 Å DetailsAuthors Chamberlain, P.P. / Matyskiela, M. / Pagarigan, B. CitationJournal : Nature / Year : 2016Title : A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.Authors: Matyskiela, M.E. / Lu, G. / Ito, T. / Pagarigan, B. / Lu, C.C. / Miller, K. / Fang, W. / Wang, N.Y. / Nguyen, D. / Houston, J. / Carmel, G. / Tran, T. / Riley, M. / Nosaka, L. / Lander, G.C. ... Authors : Matyskiela, M.E. / Lu, G. / Ito, T. / Pagarigan, B. / Lu, C.C. / Miller, K. / Fang, W. / Wang, N.Y. / Nguyen, D. / Houston, J. / Carmel, G. / Tran, T. / Riley, M. / Nosaka, L. / Lander, G.C. / Gaidarova, S. / Xu, S. / Ruchelman, A.L. / Handa, H. / Carmichael, J. / Daniel, T.O. / Cathers, B.E. / Lopez-Girona, A. / Chamberlain, P.P. History Deposition Jan 30, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 29, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Jul 6, 2016 Group : Database referencesRevision 1.2 Jul 27, 2016 Group : Database referencesRevision 1.3 Nov 1, 2017 Group : Advisory / Author supporting evidence ... Advisory / Author supporting evidence / Database references / Derived calculations Category : citation / pdbx_struct_assembly_auth_evidence ... citation / pdbx_struct_assembly_auth_evidence / pdbx_struct_oper_list / pdbx_unobs_or_zero_occ_atoms Item : _citation.journal_id_CSD / _pdbx_struct_oper_list.symmetry_operationRevision 1.4 Sep 27, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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