登録情報 | データベース: PDB / ID: 4hsg |
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タイトル | Crystal structure of human PRMT3 in complex with an allosteric inhibitor (PRMT3- KTD) |
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要素 | PRMT3 protein |
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / PRMT3 / allosteric inhibitor / Structural Genomics / Structural Genomics Consortium / SGC / TRANSFERASE-TRANSFERASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
protein-arginine omega-N monomethyltransferase activity / negative regulation of retinoic acid biosynthetic process / type I protein arginine methyltransferase / protein-arginine omega-N asymmetric methyltransferase activity / protein-arginine N-methyltransferase activity / Protein methylation / negative regulation of protein ubiquitination / methyltransferase activity / RMTs methylate histone arginines / ribosome binding ...protein-arginine omega-N monomethyltransferase activity / negative regulation of retinoic acid biosynthetic process / type I protein arginine methyltransferase / protein-arginine omega-N asymmetric methyltransferase activity / protein-arginine N-methyltransferase activity / Protein methylation / negative regulation of protein ubiquitination / methyltransferase activity / RMTs methylate histone arginines / ribosome binding / methylation / nucleus / metal ion binding / cytoplasm / cytosol類似検索 - 分子機能 : / : / Protein arginine N-methyltransferase 3, C2H2 zinc finger domain / Protein arginine N-methyltransferase 3, C2H2 zinc finger / Ribosomal protein L11 methyltransferase (PrmA) / Hnrnp arginine n-methyltransferase1 / Hnrnp arginine n-methyltransferase1 / Protein arginine N-methyltransferase / SAM-dependent methyltransferase PRMT-type domain profile. / Zinc finger C2H2 superfamily ...: / : / Protein arginine N-methyltransferase 3, C2H2 zinc finger domain / Protein arginine N-methyltransferase 3, C2H2 zinc finger / Ribosomal protein L11 methyltransferase (PrmA) / Hnrnp arginine n-methyltransferase1 / Hnrnp arginine n-methyltransferase1 / Protein arginine N-methyltransferase / SAM-dependent methyltransferase PRMT-type domain profile. / Zinc finger C2H2 superfamily / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-type / Vaccinia Virus protein VP39 / Distorted Sandwich / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta類似検索 - ドメイン・相同性 Chem-KTD / Protein arginine N-methyltransferase 3 / PRMT3 protein類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.3 Å |
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データ登録者 | Dobrovetsky, E. / Dong, A. / Liu, F. / Li, F. / Tempel, W. / Siarheyeva, A. / Hajian, T. / Smil, D. / Bountra, C. / Arrowsmith, C.H. ...Dobrovetsky, E. / Dong, A. / Liu, F. / Li, F. / Tempel, W. / Siarheyeva, A. / Hajian, T. / Smil, D. / Bountra, C. / Arrowsmith, C.H. / Edwards, A.M. / Brown, P.J. / Schapira, M. / Jin, J. / Vedadi, M. / Structural Genomics Consortium (SGC) |
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引用 | ジャーナル: J. Med. Chem. / 年: 2013 タイトル: Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors. 著者: Liu, F. / Li, F. / Ma, A. / Dobrovetsky, E. / Dong, A. / Gao, C. / Korboukh, I. / Liu, J. / Smil, D. / Brown, P.J. / Frye, S.V. / Arrowsmith, C.H. / Schapira, M. / Vedadi, M. / Jin, J. |
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履歴 | 登録 | 2012年10月30日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2012年12月5日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年5月16日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2023年9月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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