Entry Database : PDB / ID : 3zr7 Structure visualization Downloads & linksTitle Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators ComponentsPROGESTERONE RECEPTOR Details Keywords RECEPTOR / AGONIST / ANTAGONISTFunction / homology Function and homology informationFunction Domain/homology Component
glandular epithelial cell maturation / tertiary branching involved in mammary gland duct morphogenesis / ovulation from ovarian follicle / negative regulation of phosphorylation / paracrine signaling / maintenance of protein location in nucleus / regulation of epithelial cell proliferation / nuclear steroid receptor activity / lung alveolus development / progesterone receptor signaling pathway ... glandular epithelial cell maturation / tertiary branching involved in mammary gland duct morphogenesis / ovulation from ovarian follicle / negative regulation of phosphorylation / paracrine signaling / maintenance of protein location in nucleus / regulation of epithelial cell proliferation / nuclear steroid receptor activity / lung alveolus development / progesterone receptor signaling pathway / estrogen response element binding / nuclear receptor-mediated steroid hormone signaling pathway / Nuclear signaling by ERBB4 / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / steroid binding / SUMOylation of intracellular receptors / G protein-coupled receptor activity / Nuclear Receptor transcription pathway / transcription coactivator binding / nuclear receptor activity / cell-cell signaling / ATPase binding / DNA-binding transcription activator activity, RNA polymerase II-specific / Estrogen-dependent gene expression / mitochondrial outer membrane / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of gene expression / signaling receptor binding / regulation of transcription by RNA polymerase II / positive regulation of gene expression / chromatin / regulation of DNA-templated transcription / enzyme binding / signal transduction / positive regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / nucleoplasm / identical protein binding / plasma membrane / cytosol Similarity search - Function Progesterone receptor / Progesterone receptor / : / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. ... Progesterone receptor / Progesterone receptor / : / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Ligand-binding domain of nuclear hormone receptor / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / OTHER / Resolution : 1.65 Å DetailsAuthors Lusher, S.J. / Raaijmakers, H.C.A. / Vu-Pham, D. / Dechering, K. / Wai Lam, T. / Brown, A.R. / Hamilton, N.M. / Nimz, O. / Azevedo, R. / McGuire, R. ...Lusher, S.J. / Raaijmakers, H.C.A. / Vu-Pham, D. / Dechering, K. / Wai Lam, T. / Brown, A.R. / Hamilton, N.M. / Nimz, O. / Azevedo, R. / McGuire, R. / Oubrie, A. / de Vlieg, J. CitationJournal : J. Biol. Chem. / Year : 2011Title : Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators.Authors : Lusher, S.J. / Raaijmakers, H.C. / Vu-Pham, D. / Dechering, K. / Lam, T.W. / Brown, A.R. / Hamilton, N.M. / Nimz, O. / Bosch, R. / McGuire, R. / Oubrie, A. / de Vlieg, J. History Deposition Jun 15, 2011 Deposition site : PDBE / Processing site : PDBERevision 1.0 Aug 17, 2011 Provider : repository / Type : Initial releaseRevision 1.1 Oct 26, 2011 Group : Database referencesRevision 1.2 Dec 27, 2017 Group : Database references / Structure summary / Category : audit_author / citation / citation_authorItem : _audit_author.name / _citation.journal_abbrev ... _audit_author.name / _citation.journal_abbrev / _citation.journal_id_ISSN / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.title / _citation_author.name Revision 1.3 May 8, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
Show all Show less