- PDB-3m94: Complex crystal structure of Ascaris suum eIF4E-3 with m2,2,7G cap -
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Basic information
Entry
Database: PDB / ID: 3m94
Title
Complex crystal structure of Ascaris suum eIF4E-3 with m2,2,7G cap
Components
Eukaryotic translation initiation factor 4E-binding protein 1
Translation initiation factor 4E
Keywords
TRANSLATION / eIF4E / Berkeley Structural Genomics Center / BSGC
Function / homology
Function and homology information
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / eukaryotic initiation factor 4E binding / RNA 7-methylguanosine cap binding / mTORC1-mediated signalling / TOR signaling / translation repressor activity / negative regulation of translational initiation / translation initiation factor binding / translation initiation factor activity / positive regulation of mitotic cell cycle ...Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / eukaryotic initiation factor 4E binding / RNA 7-methylguanosine cap binding / mTORC1-mediated signalling / TOR signaling / translation repressor activity / negative regulation of translational initiation / translation initiation factor binding / translation initiation factor activity / positive regulation of mitotic cell cycle / G1/S transition of mitotic cell cycle / negative regulation of translation / nucleus / cytoplasm / cytosol Similarity search - Function
Eukaryotic translation initiation factor 4E binding / Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) / RNA Cap, Translation Initiation Factor Eif4e / RNA Cap, Translation Initiation Factor Eif4e / Eukaryotic translation initiation factor 4E (eIF-4E), conserved site / Eukaryotic initiation factor 4E signature. / Translation Initiation factor eIF- 4e / Eukaryotic initiation factor 4E / Translation Initiation factor eIF- 4e-like / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homology
Mass: 22169.328 Da / Num. of mol.: 1 / Fragment: UNP residues 49-236 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Ascaris suum (pig roundworm) / Strain: Ascaris suum / Plasmid: pET30a / Production host: Escherichia coli (E. coli) / Strain (production host): Rosetta / References: UniProt: Q6PKX2
#2: Protein/peptide
Eukaryotictranslationinitiationfactor4E-bindingprotein1 / eIF4E-binding protein 1 / 4E-BP1 / Phosphorylated heat- and acid-stable protein regulated by ...eIF4E-binding protein 1 / 4E-BP1 / Phosphorylated heat- and acid-stable protein regulated by insulin 1 / PHAS-I
Mass: 2144.564 Da / Num. of mol.: 1 / Fragment: UNP residues 51-67 / Source method: obtained synthetically / Source: (synth.) Homo sapiens (human) / References: UniProt: Q13541
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