登録情報 | データベース: PDB / ID: 3hfb |
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タイトル | Crystal structure of human tryoptophan hydroxylase type 1 with LP-534193 |
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要素 | Tryptophan 5-hydroxylase 1 |
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キーワード | OXIDOREDUCTASE / Tryptophan Hydroxylase type 1 / Iron / Metal-binding / Monooxygenase / Phosphoprotein / Serotonin biosynthesis |
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機能・相同性 | 機能・相同性情報
regulation of hemostasis / tryptophan 5-monooxygenase / tryptophan 5-monooxygenase activity / Serotonin and melatonin biosynthesis / aromatic amino acid metabolic process / serotonin biosynthetic process / platelet degranulation / bone remodeling / NGF-stimulated transcription / negative regulation of ossification ...regulation of hemostasis / tryptophan 5-monooxygenase / tryptophan 5-monooxygenase activity / Serotonin and melatonin biosynthesis / aromatic amino acid metabolic process / serotonin biosynthetic process / platelet degranulation / bone remodeling / NGF-stimulated transcription / negative regulation of ossification / response to immobilization stress / positive regulation of fat cell differentiation / mammary gland alveolus development / circadian rhythm / neuron projection / iron ion binding / cytosol類似検索 - 分子機能 Tryptophan 5-monooxygenase / Tryptophan 5-hydroxylase, catalytic domain / Phenylalanine Hydroxylase / Aromatic amino acid hydroxylase / Tyrosine 3-monooxygenase-like / Aromatic amino acid hydroxylase, iron/copper binding site / Biopterin-dependent aromatic amino acid hydroxylases signature. / Aromatic amino acid hydroxylase / Aromatic amino acid hydroxylase, C-terminal / Aromatic amino acid monoxygenase, C-terminal domain superfamily ...Tryptophan 5-monooxygenase / Tryptophan 5-hydroxylase, catalytic domain / Phenylalanine Hydroxylase / Aromatic amino acid hydroxylase / Tyrosine 3-monooxygenase-like / Aromatic amino acid hydroxylase, iron/copper binding site / Biopterin-dependent aromatic amino acid hydroxylases signature. / Aromatic amino acid hydroxylase / Aromatic amino acid hydroxylase, C-terminal / Aromatic amino acid monoxygenase, C-terminal domain superfamily / Aromatic amino acid hydroxylase superfamily / Biopterin-dependent aromatic amino acid hydroxylase / Biopterin-dependent aromatic amino acid hydroxylase family profile. / ACT domain profile. / ACT domain / ACT-like domain / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.92 Å |
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データ登録者 | Tari, L.W. / Swanson, R.V. / Hunter, M.J. |
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引用 | ジャーナル: Curr Chem Genomics / 年: 2010 タイトル: Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis. 著者: Cianchetta, G. / Stouch, T. / Yu, W. / Shi, Z.C. / Tari, L.W. / Swanson, R.V. / Hunter, M.J. / Hoffman, I.D. / Liu, Q. |
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履歴 | 登録 | 2009年5月11日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2010年4月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2012年3月28日 | Group: Database references |
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改定 1.3 | 2021年10月13日 | Group: Database references / Derived calculations / カテゴリ: database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.4 | 2024年2月21日 | Group: Data collection カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / diffrn_radiation_wavelength / diffrn_source Item: _diffrn_source.pdbx_wavelength_list |
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