Entry | Database: PDB / ID: 5tpg |
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Title | Optimization of spirocyclic proline tryptophanhydroxylase-1 inhibitors |
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Components | Tryptophan 5-hydroxylase 1 |
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Keywords | OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor / TPH1 / Iron / acyl / quanidine / OXIDOREDUCTASE-INHIBITOR complex / OXIDOREDUCTASE-OXIDOREDUCTASE inhibitor complex |
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Function / homology | Function and homology information
regulation of hemostasis / tryptophan 5-monooxygenase / tryptophan 5-monooxygenase activity / Serotonin and melatonin biosynthesis / aromatic amino acid metabolic process / serotonin biosynthetic process / platelet degranulation / bone remodeling / NGF-stimulated transcription / negative regulation of ossification ...regulation of hemostasis / tryptophan 5-monooxygenase / tryptophan 5-monooxygenase activity / Serotonin and melatonin biosynthesis / aromatic amino acid metabolic process / serotonin biosynthetic process / platelet degranulation / bone remodeling / NGF-stimulated transcription / negative regulation of ossification / response to immobilization stress / positive regulation of fat cell differentiation / mammary gland alveolus development / circadian rhythm / neuron projection / iron ion binding / cytosolSimilarity search - Function Tryptophan 5-monooxygenase / Tryptophan 5-hydroxylase, catalytic domain / Phenylalanine Hydroxylase / Aromatic amino acid hydroxylase / Tyrosine 3-monooxygenase-like / Aromatic amino acid hydroxylase, iron/copper binding site / Biopterin-dependent aromatic amino acid hydroxylases signature. / Aromatic amino acid hydroxylase / Aromatic amino acid hydroxylase, C-terminal / Aromatic amino acid monoxygenase, C-terminal domain superfamily ...Tryptophan 5-monooxygenase / Tryptophan 5-hydroxylase, catalytic domain / Phenylalanine Hydroxylase / Aromatic amino acid hydroxylase / Tyrosine 3-monooxygenase-like / Aromatic amino acid hydroxylase, iron/copper binding site / Biopterin-dependent aromatic amino acid hydroxylases signature. / Aromatic amino acid hydroxylase / Aromatic amino acid hydroxylase, C-terminal / Aromatic amino acid monoxygenase, C-terminal domain superfamily / Aromatic amino acid hydroxylase superfamily / Biopterin-dependent aromatic amino acid hydroxylase / Biopterin-dependent aromatic amino acid hydroxylase family profile. / ACT domain profile. / ACT domain / ACT-like domain / Orthogonal Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 1.5 Å |
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Authors | Stein, A.J. / Goldberg, D.R. / De Lombaert, S. / Holt, M.C. |
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Citation | Journal: Bioorg. Med. Chem. Lett. / Year: 2017 Title: Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Authors: Goldberg, D.R. / De Lombaert, S. / Aiello, R. / Bourassa, P. / Barucci, N. / Zhang, Q. / Paralkar, V. / Stein, A.J. / Holt, M. / Valentine, J. / Zavadoski, W. |
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History | Deposition | Oct 20, 2016 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Jan 25, 2017 | Provider: repository / Type: Initial release |
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Revision 1.1 | Nov 22, 2017 | Group: Refinement description / Category: software |
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Revision 1.2 | Mar 6, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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