EMDB-23938: Cryo-EM structure of the human SSU processome, state post-A1

Basic information

• Entry: Database: EMDB / ID: EMD-23938
• Title: Cryo-EM structure of the human SSU processome, state post-A1

Sample

• Complex: Human SSU processome
  • RNA: x 3 types
  • Protein or peptide: x 65 types
• Ligand: x 5 types

Function / homology

Function:

preribosome / nucleolar exosome (RNase complex) / oocyte growth / nucleologenesis / 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase / 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity / U4atac snRNP / snoRNA localization / nuclear polyadenylation-dependent antisense transcript catabolic process / nuclear polyadenylation-dependent snoRNA catabolic process / nuclear polyadenylation-dependent snRNA catabolic process / granular component / U4atac snRNA binding / positive regulation of mRNA cis splicing, via spliceosome / nuclear polyadenylation-dependent CUT catabolic process / cytoplasmic exosome (RNase complex) / TRAMP-dependent tRNA surveillance pathway / t-UTP complex / CUT catabolic process / CURI complex / UTP-C complex / regulation of telomerase RNA localization to Cajal body / positive regulation of male gonad development / nuclear polyadenylation-dependent rRNA catabolic process / RNA exonuclease activity / Pwp2p-containing subcomplex of 90S preribosome / regulation of stem cell population maintenance / poly(A)-dependent snoRNA 3'-end processing / exosome (RNase complex) / nuclear exosome (RNase complex) / box C/D sno(s)RNA binding / histone H2AQ104 methyltransferase activity / Mpp10 complex / rRNA (pseudouridine) methyltransferase activity / exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / rRNA (adenine-N6,N6-)-dimethyltransferase activity / endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / dense fibrillar component / pre-snoRNP complex / regulation of transcription elongation by RNA polymerase II / box C/D sno(s)RNA 3'-end processing / tRNA export from nucleus / histone mRNA catabolic process / nuclear mRNA surveillance / endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / rRNA methyltransferase activity / histone methyltransferase binding / positive regulation of rRNA processing / box C/D methylation guide snoRNP complex / positive regulation of respiratory burst involved in inflammatory response / rRNA base methylation / transcription elongation factor activity / nucleolus organization / : / epigenetic programming in the zygotic pronuclei / RNA splicing, via transesterification reactions / blastocyst formation / spindle assembly involved in female meiosis / rRNA primary transcript binding / cilium disassembly / negative regulation of RNA splicing / sno(s)RNA-containing ribonucleoprotein complex / U4 snRNA binding / Cul4-RING E3 ubiquitin ligase complex / telomerase RNA binding / U2-type precatalytic spliceosome / protein localization to nucleolus / box C/D snoRNP assembly / SUMOylation of RNA binding proteins / negative regulation of telomere maintenance via telomerase / neural crest cell differentiation / rRNA modification in the nucleus and cytosol / RNA catabolic process / rRNA methylation / nuclear-transcribed mRNA catabolic process / U3 snoRNA binding / Formation of the ternary complex, and subsequently, the 43S complex / erythrocyte homeostasis / cytoplasmic side of rough endoplasmic reticulum membrane / response to stimulus / ubiquitin ligase inhibitor activity / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / negative regulation of ubiquitin protein ligase activity / Ribosomal scanning and start codon recognition / precatalytic spliceosome / preribosome, small subunit precursor / Translation initiation complex formation / maturation of 5.8S rRNA / snoRNA binding / positive regulation of transcription by RNA polymerase I / fibroblast growth factor binding / RNA polymerase II complex binding / SARS-CoV-1 modulates host translation machinery / Protein hydroxylation / TOR signaling / single fertilization / 90S preribosome / mTORC1-mediated signalling / Association of TriC/CCT with target proteins during biosynthesis

Domain/homology:

Active regulator of SIRT1 / Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1 / Nucleolar protein 7, C-terminal / Rrp7A, RNA recognition motif / Nucleolar protein 7 / NUC129 domain / : / Exosome-associated factor Rrp6, N-terminal / Exosome complex exonuclease Rrp6-like / PMC2NT (NUC016) domain / U3 small nucleolar RNA-associated protein 20, N-terminal / U3 small nucleolar RNA-associated protein 20, C-terminal / U3 small nucleolar RNA-associated protein 20, N-terminal / U3 small nucleolar RNA-associated protein 20, C-terminal / Translation initiation factor, beta propellor-like domain / Eukaryotic translation initiation factor eIF2A / U3 small nucleolar RNA-associated protein 6 / rRNA-processing protein Fcf1, PIN domain / U3 small nucleolar RNA-associated protein 6 / NOL6/Upt22 / Small-subunit processome, Utp11 / Sof1-like protein / BING4, C-terminal domain / Fcf2 pre-rRNA processing, C-terminal / Nrap protein domain 1 / Nrap protein, domain 2 / Nrap protein, domain 3 / Nrap protein, domain 4 / Nrap protein, domain 5 / Nrap protein, domain 6 / Ribosomal RNA-processing protein Rrp9-like / Fcf2/DNTTIP2 / WD repeat-containing protein WDR46/Utp7 / Nrap protein domain 1 / Utp11 protein / Sof1-like domain / BING4CT (NUC141) domain / Fcf2 pre-rRNA processing / Nrap protein PAP/OAS-like domain / Nrap protein domain 3 / Nrap protein nucleotidyltransferase domain 4 / Nrap protein PAP/OAS1-like domain 5 / Nrap protein domain 6 / BING4CT (NUC141) domain / rRNA-processing protein Fcf1/Utp23 / Ribosomal RNA-processing protein 7, C-terminal domain / Ribosomal RNA-processing protein 7 / Rrp7, RRM-like N-terminal domain / Fcf1 / Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain / Rrp7 RRM-like N-terminal domain / Small-subunit processome, Utp14 / U3 small nucleolar RNA-associated protein 15, C-terminal / Utp14 protein / UTP15 C terminal / Sas10 C-terminal domain / Sas10 C-terminal domain / Nucleolar protein 58/56, N-terminal / U3 small nucleolar RNA-associated protein 18 / NOP5NT (NUC127) domain / BP28, C-terminal domain / RNA 3'-terminal phosphate cyclase-like, conserved site / U3 small nucleolar RNA-associated protein 10, N-terminal / Ribosome biogenesis protein Bms1, N-terminal / U3 small nucleolar RNA-associated protein 10 / BP28CT (NUC211) domain / U3 small nucleolar RNA-associated protein 10 / RNA 3'-terminal phosphate cyclase signature. / BP28CT (NUC211) domain / U3 small nucleolar RNA-associated protein 13, C-terminal / Periodic tryptophan protein 2 / Utp13 specific WD40 associated domain / Small-subunit processome, Utp12 / Dip2/Utp12 Family / Sas10/Utp3/C1D / Small-subunit processome, Utp21 / U3 small nucleolar ribonucleoprotein complex, subunit Mpp10 / RNA 3'-terminal phosphate cyclase type 2 / Sas10/Utp3/C1D family / Mpp10 protein / Utp21 specific WD40 associated putative domain / Helicase and RNase D C-terminal / HRDC domain / HRDC domain / HRDC domain profile. / Ribosomal biogenesis, methyltransferase, EMG1/NEP1 / EMG1/NEP1 methyltransferase / RNA 3'-terminal phosphate cyclase / RNA 3'-terminal phosphate cyclase, insert domain / RNA 3'-terminal phosphate cyclase domain / RNA 3'-terminal phosphate cyclase, insert domain superfamily / RNA 3'-terminal phosphate cyclase domain superfamily / RNA 3'-terminal phosphate cyclase / RNA 3'-terminal phosphate cyclase (RTC), insert domain / Ribosomal RNA adenine dimethylase / Nucleolar protein Nop56/Nop58 / rRNA 2'-O-methyltransferase fibrillarin-like / Fibrillarin, conserved site / Fibrillarin / Fibrillarin signature.

Component:

U3 small nucleolar ribonucleoprotein protein MPP10 / Nucleolar protein 56 / WD repeat-containing protein 46 / U3 small nucleolar RNA-interacting protein 2 / Small subunit processome component 20 homolog / Small ribosomal subunit protein eS17 / rRNA 2'-O-methyltransferase fibrillarin / Small ribosomal subunit protein eS12 / Small ribosomal subunit protein eS19 / Small ribosomal subunit protein eS27 / Small ribosomal subunit protein uS4 / Small ribosomal subunit protein uS7 / NHP2-like protein 1 / Small ribosomal subunit protein eS1 / Small ribosomal subunit protein eS7 / Small ribosomal subunit protein eS8 / Small ribosomal subunit protein uS8 / Small ribosomal subunit protein uS9 / Small ribosomal subunit protein uS11 / Small ribosomal subunit protein uS12 / Small ribosomal subunit protein uS15 / Small ribosomal subunit protein uS17 / Small ribosomal subunit protein eS4, X isoform / Small ribosomal subunit protein eS6 / Small ribosomal subunit protein eS24 / Small ribosomal subunit protein eS28 / Ubiquitin-ribosomal protein eS31 fusion protein / Exosome complex component 10 / Transducin beta-like protein 3 / Ribosome biogenesis protein BMS1 homolog / WD repeat-containing protein 43 / Periodic tryptophan protein 2 homolog / Deoxynucleotidyltransferase terminal-interacting protein 2 / Active regulator of SIRT1 / WD repeat-containing protein 75 / Probable ATP-dependent RNA helicase DHX37 / WD repeat-containing protein 36 / U3 small nucleolar RNA-associated protein 15 homolog / Ribosomal RNA small subunit methyltransferase NEP1 / U3 small nucleolar RNA-associated protein 4 homolog / U3 small nucleolar ribonucleoprotein protein IMP4 / U3 small nucleolar RNA-associated protein 14 homolog A / HEAT repeat-containing protein 1 / Nucleolar protein 6 / Something about silencing protein 10 / RNA-binding protein PNO1 / DDB1- and CUL4-associated factor 13 / U3 small nucleolar ribonucleoprotein protein IMP3 / U3 small nucleolar RNA-associated protein 6 homolog / U3 small nucleolar RNA-associated protein NOL7 / Probable dimethyladenosine transferase / WD repeat-containing protein 3 / RNA 3'-terminal phosphate cyclase-like protein / Nucleolar protein 58 / rRNA-processing protein FCF1 homolog / Probable U3 small nucleolar RNA-associated protein 11 / Ribosomal RNA-processing protein 7 homolog A / U3 small nucleolar RNA-associated protein 18 homolog

• Biological species: Homo sapiens (human) / Human (human)
• Method: single particle reconstruction / cryo EM / Resolution: 2.7 Å
• Authors: Vanden Broeck A / Singh S / Klinge S

Funding support

United States, 2 items

Organization	Grant number	Country
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)	1DP2GM123459	United States
European Molecular Biology Organization (EMBO)	ALTF 711-2019

• Citation: Journal: Science / Year: 2021; Title: Nucleolar maturation of the human small subunit processome.; Authors: Sameer Singh / Arnaud Vanden Broeck / Linamarie Miller / Malik Chaker-Margot / Sebastian Klinge / ; Abstract: The human small subunit processome mediates early maturation of the small ribosomal subunit by coupling RNA folding to subsequent RNA cleavage and processing steps. We report the high-resolution cryo–electron microscopy structures of maturing human small subunit (SSU) processomes at resolutions of 2.7 to 3.9 angstroms. These structures reveal the molecular mechanisms that enable crucial progressions during SSU processome maturation. RNA folding states within these particles are communicated to and coordinated with key enzymes that drive irreversible steps such as targeted exosome-mediated RNA degradation, protein-guided site-specific endonucleolytic RNA cleavage, and tightly controlled RNA unwinding. These conserved mechanisms highlight the SSU processome’s impressive structural plasticity, which endows this 4.5-megadalton nucleolar assembly with the distinctive ability to mature the small ribosomal subunit from within.

History

Deposition	May 5, 2021	-
Header (metadata) release	Sep 22, 2021	-
Map release	Sep 22, 2021	-
Update	Sep 29, 2021	-
Current status	Sep 29, 2021	Processing site: RCSB / Status: Released

Map

• File: Download / File: emd_23938.map.gz / Format: CCP4 / Size: 669.9 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
• Voxel size: X=Y=Z: 1.08 Å

Density

Contour Level	By AUTHOR: 3.28 / Movie #1: 3.28
Minimum - Maximum	-20.930138 - 29.079062
Average (Standard dev.)	0.036367923 (±0.79252946)

• Symmetry: Space group: 1

Details

EMDB XML:

Map geometry	Axis order X Y Z Origin 0 0 0 Dimensions 560 560 560 Spacing 560 560 560
Cell	A=B=C: 604.80005 Å α=β=γ: 90.0 °

CCP4 map header:

mode	Image stored as Reals
Å/pix. X/Y/Z	1.08	1.08	1.08
M x/y/z	560	560	560
origin x/y/z	0.000	0.000	0.000
length x/y/z	604.800	604.800	604.800
α/β/γ	90.000	90.000	90.000
MAP C/R/S	1	2	3
start NC/NR/NS	0	0	0
NC/NR/NS	560	560	560
D min/max/mean	-20.930	29.079	0.036

Supplemental data

Mask #1

• File: emd_23938_msk_1.map

Additional map: #1

• File: emd_23938_additional_1.map

Half map: #2

• File: emd_23938_half_map_1.map

Half map: #1

• File: emd_23938_half_map_2.map

Sample components

Entire : Human SSU processome

• Entire: Name: Human SSU processome

Components

• Complex: Human SSU processome
  • RNA: 5'ETS rRNA
  • RNA: 18S rRNA18S ribosomal RNA
  • RNA: U3 snoRNA
  • Protein or peptide: 40S ribosomal protein S18
  • Protein or peptide: 40S ribosomal protein S4, X isoformRibosome
  • Protein or peptide: 40S ribosomal protein S5
  • Protein or peptide: 40S ribosomal protein S6
  • Protein or peptide: 40S ribosomal protein S7
  • Protein or peptide: 40S ribosomal protein S8
  • Protein or peptide: 40S ribosomal protein S9
  • Protein or peptide: 40S ribosomal protein S12
  • Protein or peptide: 40S ribosomal protein S16
  • Protein or peptide: 40S ribosomal protein S11
  • Protein or peptide: 40S ribosomal protein S24
  • Protein or peptide: 40S ribosomal protein S28
  • Protein or peptide: WD repeat-containing protein 75
  • Protein or peptide: Nucleolar protein 11Nucleolus
  • Protein or peptide: U3 small nucleolar RNA-associated protein 15 homolog
  • Protein or peptide: WD repeat-containing protein 43
  • Protein or peptide: HEAT repeat-containing protein 1
  • Protein or peptide: U3 small nucleolar RNA-associated protein 4 homolog
  • Protein or peptide: Periodic tryptophan protein 2 homolog
  • Protein or peptide: U3 small nucleolar RNA-associated protein 6 homolog
  • Protein or peptide: WD repeat-containing protein 3
  • Protein or peptide: Transducin beta-like protein 3
  • Protein or peptide: U3 small nucleolar RNA-associated protein 18 homolog
  • Protein or peptide: WD repeat-containing protein 36
  • Protein or peptide: DDB1- and CUL4-associated factor 13
  • Protein or peptide: WD repeat-containing protein 46
  • Protein or peptide: Active regulator of SIRT1
  • Protein or peptide: U3 small nucleolar ribonucleoprotein protein IMP3
  • Protein or peptide: U3 small nucleolar ribonucleoprotein protein MPP10
  • Protein or peptide: Something about silencing protein 10
  • Protein or peptide: Nucleolar protein 7Nucleolus
  • Protein or peptide: 40S ribosomal protein S13
  • Protein or peptide: 40S ribosomal protein S14
  • Protein or peptide: Nucleolar protein 6Nucleolus
  • Protein or peptide: Ribosomal RNA-processing protein 7 homolog A
  • Protein or peptide: Probable dimethyladenosine transferase
  • Protein or peptide: 40S ribosomal protein S3a
  • Protein or peptide: 40S ribosomal protein S15a
  • Protein or peptide: 40S ribosomal protein S19
  • Protein or peptide: 40S ribosomal protein S27
  • Protein or peptide: RRP12-like protein
  • Protein or peptide: Probable ATP-dependent RNA helicase DHX37
  • Protein or peptide: Ubiquitin-40S ribosomal protein S27a
  • Protein or peptide: 40S ribosomal protein S17
  • Protein or peptide: Exosome component 10
  • Protein or peptide: Nucleolar protein 56Nucleolus
  • Protein or peptide: Nucleolar protein 58Nucleolus
  • Protein or peptide: rRNA 2'-O-methyltransferase fibrillarin
  • Protein or peptide: NHP2-like protein 1
  • Protein or peptide: U3 small nucleolar RNA-interacting protein 2
  • Protein or peptide: RNA 3'-terminal phosphate cyclase-like protein
  • Protein or peptide: Ribosome biogenesis protein BMS1 homolog
  • Protein or peptide: Ribosomal RNA small subunit methyltransferase NEP1
  • Protein or peptide: rRNA-processing protein FCF1 homolog
  • Protein or peptide: U3 small nucleolar ribonucleoprotein protein IMP4
  • Protein or peptide: Small subunit processome component 20 homolog
  • Protein or peptide: Deoxynucleotidyltransferase terminal-interacting protein 2
  • Protein or peptide: 40S ribosomal protein S23
  • Protein or peptide: U3 small nucleolar RNA-associated protein 14 homolog A
  • Protein or peptide: Nucleolar protein 14Nucleolus
  • Protein or peptide: Nucleolar complex protein 4 homolog
  • Protein or peptide: RNA-binding protein PNO1
  • Protein or peptide: Unassigned peptides
  • Protein or peptide: Probable U3 small nucleolar RNA-associated protein 11
  • Protein or peptide: Bystin
• Ligand: MAGNESIUM ION
• Ligand: ADENOSINE-5'-TRIPHOSPHATE
• Ligand: ZINC ION
• Ligand: GUANOSINE-5'-TRIPHOSPHATEGuanosine triphosphate
• Ligand: S-ADENOSYL-L-HOMOCYSTEINE

Supramolecule #1: Human SSU processome

• Supramolecule: Name: Human SSU processome / type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#68
• Source (natural): Organism: Homo sapiens (human)
• Molecular weight: Theoretical: 5 MDa

Macromolecule #1: 5'ETS rRNA

• Macromolecule: Name: 5'ETS rRNA / type: rna / ID: 1 / Number of copies: 1
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 1.1668818749999998 MDa

Sequence

String:

GCUGACACGC UGUCCUCUGG CGACCUGUCG CUGGAGAGGU UGGGCCUCCG GAUGCGCGCG GGGCUCUGGC CUACCGGUGA CCCGGCUAG CCGGCCGCGC UCCUGCUUGA GCCGCCUGCC GGGGCCCGCG GGCCUGCUGU UCUCUCGCGC GUCCGAGCGU C CCGACUCC CGGUGCCGGC CCGGGUCCGG GUCUCUGACC CACCCGGGGG CGGCGGGGAA GGCGGCGAGG GCCACCGUGC CC CCGUGCG CUCUCCGCUG CGGGCGCCCG GGGCGGCCGC GACAACCCCA CCCCGCUGGC UCCGUGCCGU GCGUGUCAGG CGU UCUCGU CUCCGCGGGG UUGUCCGCCG CCCCUUCCCC GGAGUGGGGG GUUGGCCGGA GCCGAUCGGC UCGCUGGCCG GCCG GCCGG CCUCCGCUCC CGGGGGGCUC UUCGUGAUCG AUGUGGUGAC GUCGUGCUCU CCCGGGCCGG GUCCGAGCCG CGACG GGCG AGGGGCGGAC GUUCGUGGCG AACGGGACCG UCCUUCUCGC UCCGCCCCGC GGGGGUCCCC UCGUCUCUCC UCUCCC CGC CCGCCGGCGG UGCGUGUGGG AAGGCGUGGG GUGCGGACCC CGGCCCGACC UCGCCGUCCC GCCCGCCGCC UUCUGCG UC GCGGGUGCGG GCCGGCGGGG UCCUCUGACG CGGCAGACAG CCCUCGCUGU CGCCUCCAGU GGUUGUCGAC UUGCGGGC G GCCCCCCUCC GCGGCGGUGG GGGUGCCGUC CCGCCGGCCC GUCGUGCUGC CGUCUCGGGG GGUUUGCGCG AGCGUCGGC UCCGCCUGGG CCCUUGCGGU GCUCCUGGAG CGCUCCGGGU UGUCCCUCAG GUGCCCGAGG CCGAACGGUG GUGUGUCGUU CCCGCCCCC GGCGCCCCCU CCUCCGGUCG CCGCCGCGGU GUCCGCGCGU GGGUCCUGAG GGAGCUCGUC GGUGUGGGGU U CGAGGCGG UUUGAGUGAG ACGAGACGAG ACGCGCCCCU CCCACGCGGG GAAGGGCGCC CGCCUGCUCU CGGUGAGCGC AC GUCCCGU GCUCCCCUCU GGCGGGUGCG CGCGGGCCGU GUGAGCGAUC GCGGUGGGUU CGGGCCGGUG UGACGCGUGC GCC GGCCGG CCGCCGAGGG GCUGCCGUUC UGCCUCCGAC CGGUCGUGUG UGGGUUGACU UCGGAGGCGC UCUGCCUCGG AAGG AAGGA GGUGGGUGGA CGGGGGGGCC UGGUGGGGUU GCGCGCACGC GCGCACCGGC CGGGCCCCCG CCCUGAACGC GAACG CUCG AGGUGGCCGC GCGCAGGUGU UUCCUCGUAC CGCAGGGCCC CCUCCCUUCC CCAGGCGUCC CUCGGCGCCU CUGCGG GCC CGAGGAGGAG CGGCUGGCGG GUGGGGGGAG UGUGACCCAC CCUCGGUGAG AAAAGCCUUC UCUAGCGAUC UGAGAGG CG UGCCUUGGGG GUACCGGAUC CCCCGGGCCG CCGCCUCUGU CUCUGCCUCC GUUAUGGUAG CGCUGCCGUA GCGACCCG C UCGCAGAGGA CCCUCCUCCG CUUCCCCCUC GACGGGGUUG GGGGGGAGAA GCGAGGGUUC CGCCGGCCAC CGCGGUGGU GGCCGAGUGC GGCUCGUCGC CUACUGUGGC CCGCGCCUCC CCCUUCCGAG UCGGGGGAGG AUCCCGCCGG GCCGGGCCCG GCGUUCCCA GCGGGUUGGG ACGCGGCGGC CGGCGGGCGG UGGGUGUGCG CGCCCGGCGC UCUGUCCGGC GCGUGACCCC C UCCGCCGC GAGUCGGCUC UCCGCCCGCU CCCGUGCCGA GUCGUGACCG GUGCCGACGA CCGCGUUUGC GUGGCACGGG GU CGGGCCC GCCUGGCCCU GGGAAAGCGU CCCACGGUGG GGGCGCGCCG GUCUCCCGGA GCGGGACCGG GUCGGAGGAU GGA CGAGAA UCACGAGCGA CGGUGGUGGU GGCGUGUCGG GUUCGUGGCU GCGGUCGCUC CGGGGCCCCC GGUGGCGGGG CCCC GGGGC UCGCGAGGCG GUUCUCGGUG GGGGCCGAGG GCCGUCCGGC GUCCCAGGCG GGGCGCCGCG GGACCGCCCU CGUGU CUGU GGCGGUGGGA UCCCGCGGCC GUGUUUUCCU GGUGGCCCGG CCGUGCCUGA GGUUUCUCCC CGAGCCGCCG CCUCUG CGG GCUCCCGGGU GCCCUUGCCC UCGCGGUCCC CGGCCCUCGC CCGUCUGUGC CCUCUUCCCC GCCCGCCGCC CGCCGAU CC UCUUCUUCCC CCGAGCGGCU CACCGGCUUC ACGUCCGUUG GUGGCCCCGC CUGGGACCGA ACCCGGCACC GCCUCGUG G GGCGCCGCCG CCGGCCACUG AUCGGCCCGG CGUCCGCGUC CCCCGGCGCG CGCCUUGGGG ACCGGGUCGG UGGCGCCCC GCGUGGGGCC CGGUGGGCUU CCAGGAGGGU UCCGGGGGUC GGCCUGCGGC GCGUGCGGGG GAGGAGACGG UUCCGGGGGA CCGGCCGCG ACUGCGGCGG CGGUGGUGGG GGGAGCCGCG GGGAUCGCCG AGGGCCGGUC GGCCGCCCCG GGUGCCGCGC G GUGCCGCC GGCGGCGGUG AGGCCCCGCG CGUGUGUCCC GGCCGCGGUC GGCCGCGCUC GAGGGGUCCC CGUGGCGUCC CC UUCCCCG CCGGCCGCCU UUCUCGCGCC UUCCCCGUCG CCCCGGCCUC GCCCGUGGUC UCUCGUCUUC UCCCGGCCCG CUC UUCCGA ACCGGGUCGG CGCGUCCCCC GGGUGCGCCU CGCUUCCCGG GCCUGCCGCG GCCCUUCCCC GAGGCGUCCG UCCC GGGCG UCGGCGUCGG GGAGAGCCCG UCCUCCCCGC GUGGCGUCGC CCCGUUCGGC GCGCGCGUGC GCCCGAGCGC GGCCC GGUG GUCCCUCCCG GACAGGCGUU CGUGCGACGU GUGGCGUGGG UCGACCUCCG CCUUGCCGGU CGCUCGCCCU CUCCCC GGG UCGGGGGGUG GGGCCCGGGC CGGGGCCUCG GCCCCGGUCG CGGUCCCCCG UCCCGGGCGG GGGCGGGCGC GCCGGCC GG CCUCGGUCGC CCUCCCUUGG CCGUCGUGUG GCGUGUGCCA CCCCUGCGCC CGCGCCCGCC GGCGGGGCUC GGAGCCGG G CUUCGGCCGG GCCCCGGGCC CUCGACCGGA CCGGUGCGCG GGCGCUGCGG CCGCACGGCG CGACUGUCCC CGGGCCGGG CACCGCGGUC CGCCUCUCGC UCGCCGCCCG GACGUCGGGG CCGCCCCGCG GGGCGGGCGG AGCGCCGUCC CCGCCUCGCC GCCGCCCGC GGGCGCCGGC CGCGCGCGCG CGCGCGUGGC CGCCGGUCCC UCCCGGCCGC CGGGCGCGGG UCGGGCCGUC C GCCUCCUC GCGGGCGGGC GCGACGAAGA AGCGUCGCGG GUCUGUGGCG CGGGGCCCCC GGUGGUCGUG UCGCGUGGGG GG CGGGUGG UUGGGGCGUC CGGUUCGCCG CGCCCCGCCC CGGCCCCACC GGUCCCGGCC GCCGCCCCCG CGCCCGCUCG CUC CCUCCC GUCCGCCCGU CCGCGGCCCG UCCGUCCGUC CGUCCGUCGU CCUCCUCGCU UGCGGGGCGC CGGGCCCGUC CUCG ACGCG CUCUACCUUA CC

Macromolecule #2: 18S rRNA

• Macromolecule: Name: 18S rRNA / type: rna / ID: 2 / Number of copies: 1
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 604.234375 KDa

Sequence

String:

UACCUGGUUG AUCCUGCCAG UAGCAU(A2M)UGC UUG(PSU)C(PSU)CAAA GAUUAAGCCA UGCAUGUCUA AGUACGCA C GGCCGGUACA GUGAAACUGC GAA(PSU)GGCUC(A2M) UUAAA(PSU)CAG(PSU) UAUGGU(OMU)CC(PSU) U (OMU)GGUCGCU CGCUCCUCUC CUACUUGGAU AACUGUGGUA (A2M)UUCUAG(A2M)GC UAA(OMU)A(OMC)AUGC CG ACGGGCG CUGACCCCCU UCGCGGGGGG GA(PSU)GCGUGCA (PSU)UUAUCAGAU CAAAACCAAC CCGGUCAGCC CCUCU CCGG CCCCGGCCGG GGGGCGGGCG CCGGCGGCUU UGGUGACUC(PSU) AGAUAACCUC GGGCCGAUCG CACGCCCCCC GU GGCGGCG ACGACCCAUU CGAACGUC(OMU)G CCCUAUCAAC UUUCGAUGGU AGUCGCCGUG CCUACCAUGG UGACCACGG G(PSU)GACGGGGA AUCAGGGUUC GAU(OMU)CCGGAG A(OMG)GGAGCCUG AGAAACGGCU ACCACAU(OMC)CA AGG (A2M)AGGCA GCAGGCGCGC (A2M)AAUUACCCA CUCCCGACCC GGGGA(OMG)GU(A2M)G UGA(OMC)GAAAAA UAAC AAUAC AGGACUCUUU CGAGGCCCUG UAAUUGGAAU GAGUCCACU(PSU) UAA(A2M)UCCUUU AACGAGG(A2M)UC CAU UGGAG(OMG) GCAAGUC(PSU)GG UGCCAGCAG(OMC) CGCGG(OMU)AAUU CCAGCUCCAA UA(OMG)CGUA(PSU)A (PSU)UAAAGUUGC UGCAGUU(A2M)AA AAGCUCGUAG (PSU)U(OMG)GA(PSU)CUUG GGAGCGGGCG GGCGGUCCGC CGCGAGGCG AGCCACCGCC CGUCCCCGCC CCUUGCCUCU CGGCGCCCCC UCGAUGCUCU UAGCUGAGUG UCCCGCGGGG C CCGAAG(OMC)G (OMU)U(PSU)ACUUUGA AAAAA(PSU)(PSU)AGA GUG(PSU)UCAAAG CAGGCCCGAG CCGCCUGG A UACCGCAGCU AGGAA(PSU)AA(PSU)(OMG) GAAUAGGACC GCGGUUCUAU UUUGUUGGUU UUCGGAACUG AGGCCAU GA U(PSU)AAGAGGGA CGGCCGGGGG CAUUCGUAUU GCGCCGCUAG AGGUGAAAU(PSU) CUUGGACCGG CGCAAGACGG ACCAGAGCG AAAGCAUU(PSU)G CCAAGAAUGU UUUCAUUAAU CAAGA(A2M)CGAA AGUCGGAGG(PSU) (PSU)CGAA GACG A(PSU)CAGAUACC GUCGUAGUUC CGACCA(PSU)AAA CGAUGCCGAC CGGCGAUGCG GCGGCGUUAU UCCCAUGA C CCGCCGGGCA GCUUCCGGGA AACCAAAGUC UUUGGGUUCC GGGGGGAGUA (PSU)GG(PSU)UGCAAA GCUGAAACUU A AAGGAAUU GACGGAAGGG CACCACCAGG AGUGGAGCC(PSU) GCGGCUUAAU UUGACUCAAC ACGGGAAACC UCACCCGG C CCGGACACGG ACAGGAUUGA CAGAUUGAUA GCUCUUUCUC GAUUCCGUGG GUGGUGGUGC AUGGCCGUUC UUAGUUGGU GGAGCGAUUU GUCUGGUUAA UUCCGAUAAC GAACGAGACU CUGGCAUGCU AACUAGUUAC GCGACCCCCG AGCGGUCGGC GUCCCCCAA CUUCUUAGAG GGACAAGUGG CGUUCAGCCA CCCGAGAUUG AGCAAUAACA GGUCUGUGAU GCCCUUAGAU G UCCGGGGC UGCACGCGCG CUACACUGAC UGGCUCAGCG UGUGCCUACC CUACGCCGGC AGGCGCGGGU AACCCGUUGA AC CCCAUUC GUGAUGGGGA UCGGGGAUUG CAAUUAU(PSU)CC CCAUGAACGA GGAAU(PSU)CCCA GUAAGUGCGG GUCAU AAGC UUGCGUUGAU U(A2M)AGUCCCUG CCCUUUGUAC ACACCG(OMC)CCG UCGCUACUAC CGAUUGGAUG GUUUAGUG A GGCCCUCGGA UCGGCCCCGC CGGGGUCGGC CCACGGCCCU GGCGGAGCGC UGAGAAGACG GUCGAACUUG ACUAUCUAG AGGAAGUAAA AGUCGUAACA AGGUUUC(4AC)GU AGGUGAACCU GCGGAAGGAU CAUUAACG

Macromolecule #3: U3 snoRNA

• Macromolecule: Name: U3 snoRNA / type: rna / ID: 3 / Number of copies: 1
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 70.017203 KDa

Sequence

String:

AAGACUAUAC UUUCAGGGAU CAUUUCUAUA GUGUGUUACU AGAGAAGUUU CUCUGAACGU GUAGAGCACC GAAAACCACG AGGAAGAGA GGUAGCGUUU UCUCCUGAGC GUGAAGCCGG CUUUCUGGCG UUGCUUGGCU GCAACUGCCG UCAGCCAUUG A UGAUCGUU CUUCUCUCCG UAUUGGGGAG UGAGAGGGAG AGAACGCGGU CUGAGUGGU

Macromolecule #4: 40S ribosomal protein S18

• Macromolecule: Name: 40S ribosomal protein S18 / type: protein_or_peptide / ID: 4 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 12.671983 KDa

Sequence

String:

MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI DLTKRAGELT EDEVERVITI MQNPRQYKIP DWFLNRQ(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)

Macromolecule #5: 40S ribosomal protein S4, X isoform

• Macromolecule: Name: 40S ribosomal protein S4, X isoform / type: protein_or_peptide / ID: 5 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 29.654869 KDa

Sequence

String:

MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN RLKYALTGDE VKKICMQRFI KIDGKVRTDI TYPAGFMDV ISIDKTGENF RLIYDTKGRF AVHRITPEEA KYKLCKVRKI FVGTKGIPHL VTHDARTIRY PDPLIKVNDT I QIDLETGK ITDFIKFDTG NLCMVTGGAN LGRIGVITNR ERHPGSFDVV HVKDANGNSF ATRLSNIFVI GKGNKPWISL PR GKGIRLT IAEERDKRLA AKQSSG

Macromolecule #6: 40S ribosomal protein S5

• Macromolecule: Name: 40S ribosomal protein S5 / type: protein_or_peptide / ID: 6 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 22.913453 KDa

Sequence

String:

MTEWETAAPA VAETPDIKLF GKWSTDDVQI NDISLQDYIA VKEKYAKYLP HSAGRYAAKR FRKAQCPIVE RLTNSMMMHG RNNGKKLMT VRIVKHAFEI IHLLTGENPL QVLVNAIINS GPREDSTRIG RAGTVRRQAV DVSPLRRVNQ AIWLLCTGAR E AAFRNIKT IAECLADELI NAAKGSSNSY AIKKKDELER VAKSNR

Macromolecule #7: 40S ribosomal protein S6

• Macromolecule: Name: 40S ribosomal protein S6 / type: protein_or_peptide / ID: 7 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 28.751906 KDa

Sequence

String:

MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV RISGGNDKQG FPMKQGVLTH GRVRLLLSKG HSCYRPRRT GERKRKSVRG CIVDANLSVL NLVIVKKGEK DIPGLTDTTV PRRLGPKRAS RIRKLFNLSK EDDVRQYVVR K PLNKEGKK PRTKAPKIQR LVTPRVLQHK RRRIALKKQR TKKNKEEAAE YAKLLAKRMK EAKEKRQEQI AKRRRLSSLR AS TSKSESS QK

Macromolecule #8: 40S ribosomal protein S7

• Macromolecule: Name: 40S ribosomal protein S7 / type: protein_or_peptide / ID: 8 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 22.168914 KDa

Sequence

String:

MFSSSAKIVK PNGEKPDEFE SGISQALLEL EMNSDLKAQL RELNITAAKE IEVGGGRKAI IIFVPVPQLK SFQKIQVRLV RELEKKFSG KHVVFIAQRR ILPKPTRKSR TKNKQKRPRS RTLTAVHDAI LEDLVFPSEI VGKRIRVKLD GSRLIKVHLD K AQQNNVEH KVETFSGVYK KLTGKDVNFE FPEFQL

Macromolecule #9: 40S ribosomal protein S8

• Macromolecule: Name: 40S ribosomal protein S8 / type: protein_or_peptide / ID: 9 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 24.263387 KDa

Sequence

String:

MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG GNKKYRALRL DVGNFSWGSE CCTRKTRIID VVYNASNNE LVRTKTLVKN CIVLIDSTPY RQWYESHYAL PLGRKKGAKL TPEEEEILNK KRSKKIQKKY DERKKNAKIS S LLEEQFQQ GKLLACIASR PGQCGRADGY VLEGKELEFY LRKIKARKGK

Macromolecule #10: 40S ribosomal protein S9

• Macromolecule: Name: 40S ribosomal protein S9 / type: protein_or_peptide / ID: 10 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 22.641564 KDa

Sequence

String:

MPVARSWVCR KTYVTPRRPF EKSRLDQELK LIGEYGLRNK REVWRVKFTL AKIRKAAREL LTLDEKDPRR LFEGNALLRR LVRIGVLDE GKMKLDYILG LKIEDFLERR LQTQVFKLGL AKSIHHARVL IRQRHIRVRK QVVNIPSFIV RLDSQKHIDF S LRSPYGGG RPGRVKRKNA KKGQGGAGAG DDEEED

Macromolecule #11: 40S ribosomal protein S12

• Macromolecule: Name: 40S ribosomal protein S12 / type: protein_or_peptide / ID: 11 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 14.538987 KDa

Sequence

String:

MAEEGIAAGG VMDVNTALQE VLKTALIHDG LARGIREAAK ALDKRQAHLC VLASNCDEPM YVKLVEALCA EHQINLIKVD DNKKLGEWV GLCKIDREGK PRKVVGCSCV VVKDYGKESQ AKDVIEEYFK CKK

Macromolecule #12: 40S ribosomal protein S16

• Macromolecule: Name: 40S ribosomal protein S16 / type: protein_or_peptide / ID: 12 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 16.477377 KDa

Sequence

String:

MPSKGPLQSV QVFGRKKTAT AVAHCKRGNG LIKVNGRPLE MIEPRTLQYK LLEPVLLLGK ERFAGVDIRV RVKGGGHVAQ IYAIRQSIS KALVAYYQKY VDEASKKEIK DILIQYDRTL LVADPRRCES KKFGGPGARA RYQKSYR

Macromolecule #13: 40S ribosomal protein S11

• Macromolecule: Name: 40S ribosomal protein S11 / type: protein_or_peptide / ID: 13 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 18.468826 KDa

Sequence

String:

MADIQTERAY QKQPTIFQNK KRVLLGETGK EKLPRYYKNI GLGFKTPKEA IEGTYIDKKC PFTGNVSIRG RILSGVVTKM KMQRTIVIR RDYLHYIRKY NRFEKRHKNM SVHLSPCFRD VQIGDIVTVG ECRPLSKTVR FNVLKVTKAA GTKKQFQKF

Macromolecule #14: 40S ribosomal protein S24

• Macromolecule: Name: 40S ribosomal protein S24 / type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 15.463333 KDa

Sequence

String:

MNDTVTIRTR KFMTNRLLQR KQMVIDVLHP GKATVPKTEI REKLAKMYKT TPDVIFVFGF RTHFGGGKTT GFGMIYDSLD YAKKNEPKH RLARHGLYEK KKTSRKQRKE RKNRMKKVRG TAKANVGAGK KPKE

Macromolecule #15: 40S ribosomal protein S28

• Macromolecule: Name: 40S ribosomal protein S28 / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 7.855052 KDa

Sequence

String:

MDTSRVQPIK LARVTKVLGR TGSQGQCTQV RVEFMDDTSR SIIRNVKGPV REGDVLTLLE SEREARRLR

Macromolecule #16: WD repeat-containing protein 75

• Macromolecule: Name: WD repeat-containing protein 75 / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 94.609609 KDa

Sequence

String:

MVEEENIRVV RCGGSELNFR RAVFSADSKY IFCVSGDFVK VYSTVTEECV HILHGHRNLV TGIQLNPNNH LQLYSCSLDG TIKLWDYID GILIKTFIVG CKLHALFTLA QAEDSVFVIV NKEKPDIFQL VSVKLPKSSS QEVEAKELSF VLDYINQSPK C IAFGNEGV YVAAVREFYL SVYFFKKKTT SRFTLSSSRN KKHAKNNFTC VACHPTEDCI ASGHMDGKIR LWRNFYDDKK YT YTCLHWH HDMVMDLAFS VTGTSLLSGG RESVLVEWRD ATEKNKEFLP RLGATIEHIS VSPAGDLFCT SHSDNKIIII HRN LEASAV IQGLVKDRSI FTGLMIDPRT KALVLNGKPG HLQFYSLQSD KQLYNLDIIQ QEYINDYGLI QIELTKAAFG CFGN WLATV EQRQEKETEL ELQMKLWMYN KKTQGFILNT KINMPHEDCI TALCFCNAEK SEQPTLVTAS KDGYFKVWIL TDDSD IYKK AVGWTCDFVG SYHKYQATNC CFSEDGSLLA VSFEEIVTIW DSVTWELKCT FCQRAGKIRH LCFGRLTCSK YLLGAT ENG ILCCWNLLSC ALEWNAKLNV RVMEPDPNSE NIAAISQSSV GSDLFVFKPS EPRPLYIQKG ISREKVQWGV FVPRDVP ES FTSEAYQWLN RSQFYFLTKS QSLLTFSTKS PEEKLTPTSK QLLAEESLPT TPFYFILGKH RQQQDEKLNE TLENELVQ L PLTENIPAIS ELLHTPAHVL PSAAFLCSMF VNSLLLSKET KSAKEIPEDV DMEEEKESED SDEENDFTEK VQDTSNTGL GEDIIHQLSK SEEKELRKFR KIDYSWIAAL

Macromolecule #17: Nucleolar protein 11

• Macromolecule: Name: Nucleolar protein 11 / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 73.444688 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)VIKW TKFFVVFRHP VLIFITEKHG NYFAYVQMFN SRILTKYTLL L GQDENSVI KSFTASVDRK FISLMSLSSD GCIYETLIPI RPADPEKNQS LVKSLLLKAV VSGNARNGVA LTALDQDHVA VL GSPLAAS KECLSVWNIK FQTLQTSKEL PQGTSGQLWY YGEHLFMLH(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) HVVSHFV NWETPQGCGL GFQNSEQSRR ILRRRKIEVS LQPEVPPSKQ LLSTIMKDSE KHIEVEVRKF LALKQTPDFH TVI GDTVTG LLERCKAEPS FYPRNCLMQL IQTHVLSYSL CPDLMEIALK KKDVQLLQLC LQQFPDIPES VTCACLKIFL SIGD DSLQE TDVNMESVFD YSINSVHDEK MEEQTEILQN GFNPEEDKCN NCDQELNKKP QDETKESTSC PVVQKRAALL NAILH SAYS ETFLLPHLKD IPAQHITLFL KYLYFLYLKC SENATMTLPG IHPPTLNQIM DWICLLLDAN FTVVVMMPEA KRLLIN LYK LVKSQISVYS ELNKIEVSFR ELQKLNQEKN NRGLYSIEVL ELF

Macromolecule #18: U3 small nucleolar RNA-associated protein 15 homolog

• Macromolecule: Name: U3 small nucleolar RNA-associated protein 15 homolog / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 58.503156 KDa

Sequence

String:

MAGYKPVAIQ TYPILGEKIT QDTLYWNNYK TPVQIKEFGA VSKVDFSPQP PYNYAVTASS RIHIYGRYSQ EPIKTFSRFK DTAYCATFR QDGRLLVAGS EDGGVQLFDI SGRAPLRQFE GHTKAVHTVD FTADKYHVVS GADDYTVKLW DIPNSKEILT F KEHSDYVR CGCASKLNPD LFITGSYDHT VKMFDARTSE SVLSVEHGQP VESVLLFPSG GLLVSAGGRY VKVWDMLKGG QL LVSLKNH HKTVTCLCLS SSGQRLLSGS LDRKVKVYST TSYKVVHSFD YAASILSLAL AHEDETIVVG MTNGILSVKH RKS EAKKES LPRRRRPAYR TFIKGKNYMK QRDDILINRP AKKHLELYDR DLKHFRISKA LDRVLDPTCT IKTPEITVSI IKEL NRRGV LANALAGRDE KEISHVLNFL IRNLSQPRFA PVLINAAEII IDIYLPVIGQ SPVVDKKFLL LQGLVEKEID YQREL LETL GMMDMLFATM RRKEGTSVLE HTSDGFPENK KIES

Macromolecule #19: WD repeat-containing protein 43

• Macromolecule: Name: WD repeat-containing protein 43 / type: protein_or_peptide / ID: 19 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 74.985578 KDa

Sequence

String:

MAAGGGGSCD PLAPAGVPCA FSPHSQAYFA LASTDGHLRV WETANNRLHQ EYVPSAHLSG TCTCLAWAPA RLQAKESPQR KKRKSEAVG MSNQTDLLAL GTAVGSILLY STVKGELHSK LISGGHDNRV NCIQWHQDSG CLYSCSDDKH IVEWNVQTCK V KCKWKGDN SSVSSLCISP DGKMLLSAGR TIKLWVLETK EVYRHFTGHA TPVSSLMFTT IRPPNESQPF DGITGLYFLS GA VHDRLLN VWQVRSENKE KSAVMSFTVT DEPVYIDLTL SENKEEPVKL AVVCRDGQVH LFEHILNGYC KKPLTSNCTI QIA TPGKGK KSTPKPIPIL AAGFCSDKMS LLLVYGSWFQ PTIERVALNS REPHMCLVRD ISNCWAPKVE TAITKVRTPV MNSE AKVLV PGIPGHHAAI KPAPPQTEQV ESKRKSGGNE VSIEERLGAM DIDTHKKGKE DLQTNSFPVL LTQGLESNDF EMLNK VLQT RNVNLIKKTV LRMPLHTIIP LLQELTKRLQ GHPNSAVLMV QWLKCVLTVH ASYLSTLPDL VPQLGTLYQL MESRVK TFQ KLSHLHGKLI LLITQVTASE KTKGATSPGQ KAKLVYEEES SEEESDDEIA DKDSEDNWDE DEEESESEKD EDVEEED ED AEGKDEENGE DRDTASEKEL NGDSDLDPEN ESEEE

Macromolecule #20: HEAT repeat-containing protein 1

• Macromolecule: Name: HEAT repeat-containing protein 1 / type: protein_or_peptide / ID: 20 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 242.649672 KDa

Sequence

String:

MTSLAQQLQR LALPQSDASL LSRDEVASLL FDPKEAATID RDTAFAIGCT GLEELLGIDP SFEQFEAPLF SQLAKTLERS VQTKAVNKQ LDENISLFLI HLSPYFLLKP AQKCLEWLIH RFHIHLYNQD SLIACVLPYH ETRIFVRVIQ LLKINNSKHR W FWLLPVKQ SGVPLAKGTL ITHCYKDLGF MDFICSLVTK SVKVFAEYPG SSAQLRVLLA FYASTIVSAL VAAEDVSDNI IA KLFPYIQ KGLKSSLPDY RAATYMIICQ ISVKVTMENT FVNSLASQII KTLTKIPSLI KDGLSCLIVL LQRQKPESLG KKP FPHLCN VPDLITILHG ISETYDVSPL LHYMLPHLVV SIIHHVTGEE TEGMDGQIYK RHLEAILTKI SLKNNLDHLL ASLL FEEYI SYSSQEEMDS NKVSLLNEQF LPLIRLLESK YPRTLDVVLE EHLKEIADLK KQELFHQFVS LSTSGGKYQF LADSD TSLM LSLNHPLAPV RILAMNHLKK IMKTSKEGVD ESFIKEAVLA RLGDDNIDVV LSAISAFEIF KEHFSSEVTI SNLLNL FQR AELSKNGEWY EVLKIAADIL IKEEILSEND QLSNQVVVCL LPFMVINNDD TESAEMKIAI YLSKSGICSL HPLLRGW EE ALENVIKSTK PGKLIGVANQ KMIELLADNI NLGDPSSMLK MVEDLISVGE EESFNLKQKV TFHVILSVLV SCCSSLKE T HFPFAIRVFS LLQKKIKKLE SVITAVEIPS EWHIELMLDR GIPVELWAHY VEELNSTQRV AVEDSVFLVF SLKKFIYAL KAPKSFPKGD IWWNPEQLKE DSRDYLHLLI GLFEMMLNGA DAVHFRVLMK LFIKVHLEDV FQLFKFCSVL WTYGSSLSNP LNCSVKTVL QTQALYVGCA MLSSQKTQCK HQLASISSPV VTSLLINLGS PVKEVRRAAI QCLQALSGVA SPFYLIIDHL I SKAEEITS DAAYVIQDLA TLFEELQREK KLKSHQKLSE TLKNLLSCVY SCPSYIAKDL MKVLQGVNGE MVLSQLLPMA EQ LLEKIQK EPTAVLKDEA MVLHLTLGKY NEFSVSLLNE DPKSLDIFIK AVHTTKELYA GMPTIQITAL EKITKPFFAA ISD EKVQQK LLRMLFDLLV NCKNSHCAQT VSSVFKGISV NAEQVRIELE PPDKAKPLGT VQQKRRQKMQ QKKSQDLESV QEVG GSYWQ RVTLILELLQ HKKKLRSPQI LVPTLFNLLS RCLEPLPQEQ GNMEYTKQLI LSCLLNICQK LSPDGGKIPK DILDE EKFN VELIVQCIRL SEMPQTHHHA LLLLGTVAGI FPDKVLHNIM SIFTFMGANV MRLDDTYSFQ VINKTVKMVI PALIQS DSG DSIEVSRNVE EIVVKIISVF VDALPHVPEH RRLPILVQLV DTLGAEKFLW ILLILLFEQY VTKTVLAAAY GEKDAIL EA DTEFWFSVCC EFSVQHQIQS LMNILQYLLK LPEEKEETIP KAVSFNKSES QEEMLQVFNV ETHTSKQLRH FKFLSVSF M SQLLSSNNFL KKVVESGGPE ILKGLEERLL ETVLGYISAV AQSMERNADK LTVKFWRALL SKAYDLLDKV NALLPTETF IPVIRGLVGN PLPSVRRKAL DLLNNKLQQN ISWKKTIVTR FLKLVPDLLA IVQRKKKEGE EEQAINRQTA LYTLKLLCKN FGAENPDPF VPVLNTAVKL IAPERKEEKN VLGSALLCIA EVTSTLEALA IPQLPSLMPS LLTTMKNTSE LVSSEVYLLS A LAALQKVV ETLPHFISPY LEGILSQVIH LEKITSEMGS ASQANIRLTS LKKTLATTLA PRVLLPAIKK TYKQIEKNWK NH MGPFMSI LQEHIGVMKK EELTSHQSQL TAFFLEALDF RAQHSENDLE EVGKTENCII DCLVAMVVKL SEVTFRPLFF KLF DWAKTE DAPKDRLLTF YNLADCIAEK LKGLFTLFAG HLVKPFADTL NQVNISKTDE AFFDSENDPE KCCLLLQFIL NCLY KIFLF DTQHFISKER AEALMMPLVD QLENRLGGEE KFQERVTKHL IPCIAQFSVA MADDSLWKPL NYQILLKTRD SSPKV RFAA LITVLALAEK LKENYIVLLP ESIPFLAELM EDECEEVEHQ CQKTIQQLET VLGEPLQSYF

Macromolecule #21: U3 small nucleolar RNA-associated protein 4 homolog

• Macromolecule: Name: U3 small nucleolar RNA-associated protein 4 homolog / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 76.993055 KDa

Sequence

String:

MGEFKVHRVR FFNYVPSGIR CVAYNNQSNR LAVSRTDGTV EIYNLSANYF QEKFFPGHES RATEALCWAE GQRLFSAGLN GEIMEYDLQ ALNIKYAMDA FGGPIWSMAA SPSGSQLLVG CEDGSVKLFQ ITPDKIQFER NFDRQKSRIL SLSWHPSGTH I AAGSIDYI SVFDVKSGSA VHKMIVDRQY MGVSKRKCIV WGVAFLSDGT IISVDSAGKV QFWDSATGTL VKSHLIANAD VQ SIAVADQ EDSFVVGTAE GTVFHFQLVP VTSNSSEKQW VRTKPFQHHT HDVRTVAHSP TALISGGTDT HLVFRPLMEK VEV KNYDAA LRKITFPHRC LISCSKKRQL LLFQFAHHLE LWRLGSTVAT GKNGDTLPLS KNADHLLHLK TKGPENIICS CISP CGSWI AYSTVSRFFL YRLNYEHDNI SLKRVSKMPA FLRSALQILF SEDSTKLFVA SNQGALHIVQ LSGGSFKHLH AFQPQ SGTV EAMCLLAVSP DGNWLAASGT SAGVHVYNVK QLKLHCTVPA YNFPVTAMAI APNTNNLVIA HSDQQVFEYS IPDKQY TDW SRTVQKQGFH HLWLQRDTPI THISFHPKRP MHILLHDAYM FCIIDKSLPL PNDKTLLYNP FPPTNESDVI RRRTAHA FK ISKIYKPLLF MDLLDERTLV AVERPLDDII AQLPPPIKKK KFGT

Macromolecule #22: Periodic tryptophan protein 2 homolog

• Macromolecule: Name: Periodic tryptophan protein 2 homolog / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 102.574977 KDa

Sequence

String:

MKFAYRFSNL LGTVYRRGNL NFTCDGNSVI SPVGNRVTVF DLKNNKSDTL PLATRYNVKC VGLSPDGRLA IIVDEGGDAL LVSLVCRSV LHHFHFKGSV HSVSFSPDGR KFVVTKGNIA QMYHAPGKKR EFNAFVLDKT YFGPYDETTC IDWTDDSRCF V VGSKDMST WVFGAERWDN LIYYALGGHK DAIVACFFES NSLDLYSLSQ DGVLCMWQCD TPPEGLRLKP PAGWKADLLQ RE EEEEEEE DQEGDRETTI RGKATPAEEE KTGKVKYSRL AKYFFNKEGD FNNLTAAAFH KKSHLLVTGF ASGIFHLHEL PEF NLIHSL SISDQSIASV AINSSGDWIA FGCSGLGQLL VWEWQSESYV LKQQGHFNSM VALAYSPDGQ YIVTGGDDGK VKVW NTLSG FCFVTFTEHS SGVTGVTFTA TGYVVVTSSM DGTVRAFDLH RYRNFRTFTS PRPTQFSCVA VDASGEIVSA GAQDS FEIF VWSMQTGRLL DVLSGHEGPI SGLCFNPMKS VLASASWDKT VRLWDMFDSW RTKETLALTS DALAVTFRPD GAELAV ATL NSQITFWDPE NAVQTGSIEG RHDLKTGRKE LDKITAKHAA KGKAFTALCY SADGHSILAG GMSKFVCIYH VREQILM KR FEISCNLSLD AMEEFLNRRK MTEFGNLALI DQDAGQEDGV AIPLPGVRKG DMSSRHFKPE IRVTSLRFSP TGRCWAAT T TEGLLIYSLD TRVLFDPFEL DTSVTPGRVR EALRQQDFTR AILMALRLNE SKLVQEALEA VPRGEIEVVT SSLPELYVE KVLEFLASSF EVSRHLEFYL LWTHKLLMLH GQKLKSRAGT LLPVIQFLQK SIQRHLDDLS KLCSWNHYNM QYALAVSKQR GTKRSLDPL GSEEEAEASE DDSLHLLGGG GRDSEEEMLA

Macromolecule #23: U3 small nucleolar RNA-associated protein 6 homolog

• Macromolecule: Name: U3 small nucleolar RNA-associated protein 6 homolog / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 70.297891 KDa

Sequence

String:

MAEIIQERIE DRLPELEQLE RIGLFSHAEI KAIIKKASDL EYKIQRRTLF KEDFINYVQY EINLLELIQR RRTRIGYSFK KDEIENSIV HRVQGVFQRA SAKWKDDVQL WLSYVAFCKK WATKTRLSKV FSAMLAIHSN KPALWIMAAK WEMEDRLSSE S ARQLFLRA LRFHPECPKL YKEYFRMELM HAEKLRKEKE EFEKASMDVE NPDYSEEILK GELAWIIYKN SVSIIKGAEF HV SLLSIAQ LFDFAKDLQK EIYDDLQALH TDDPLTWDYV ARRELEIESQ TEEQPTTKQA KAVEVGRKEE RCCAVYEEAV KTL PTEAMW KCYITFCLER FTKKSNSGFL RGKRLERTMT VFRKAHELKL LSECQYKQLS VSLLCYNFLR EALEVAVAGT ELFR DSGTM WQLKLQVLIE SKSPDIAMLF EEAFVHLKPQ VCLPLWISWA EWSEGAKSQE DTEAVFKKAL LAVIGADSVT LKNKY LDWA YRSGGYKKAR AVFKSLQESR PFSVDFFRKM IQFEKEQESC NMANIREYYE RALREFGSAD SDLWMDYMKE ELNHPL GRP ENCGQIYWRA MKMLQGESAE AFVAKHAMHQ TGHL

Macromolecule #24: WD repeat-containing protein 3

• Macromolecule: Name: WD repeat-containing protein 3 / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 106.248 KDa

Sequence

String:

MGLTKQYLRY VASAVFGVIG SQKGNIVFVT LRGEKGRYVA VPACEHVFIW DLRKGEKILI LQGLKQEVTC LCPSPDGLHL AVGYEDGSI RIFSLLSGEG NVTFNGHKAA ITTLKYDQLG GRLASGSKDT DIIVWDVINE SGLYRLKGHK DAITQALFLR E KNLLVTSG KDTMVKWWDL DTQHCFKTMV GHRTEVWGLV LLSEEKRLIT GASDSELRVW DIAYLQEIED PEEPDPKKIK GS SPGIQDT LEAEDGAFET DEAPEDRILS CRKAGSIMRE GRDRVVNLAV DKTGRILACH GTDSVLELFC ILSKKEIQKK MDK KMKKAR KKAKLHSSKG EEEDPEVNVE MSLQDEIQRV TNIKTSAKIK SFDLIHSPHG ELKAVFLLQN NLVELYSLNP SLPT PQPVR TSRITIGGHR SDVRTLSFSS DNIAVLSAAA DSIKIWNRST LQCIRTMTCE YALCSFFVPG DRQVVIGTKT GKLQL YDLA SGNLLETIDA HDGALWSMSL SPDQRGFVTG GADKSVKFWD FELVKDENST QKRLSVKQTR TLQLDEDVLC VSYSPN QKL LAVSLLDCTV KIFYVDTLKF FLSLYGHKLP VICMDISHDG ALIATGSADR NVKIWGLDFG DCHKSLFAHD DSVMYLQ FV PKSHLFFTAG KDHKIKQWDA DKFEHIQTLE GHHQEIWCLA VSPSGDYVVS SSHDKSLRLW ERTREPLILE EEREMERE A EYEESVAKED QPAVPGETQG DSYFTGKKTI ETVKAAERIM EAIELYREET AKMKEHKAIC KAAGKEVPLP SNPILMAYG SISPSAYVLE IFKGIKSSEL EESLLVLPFS YVPDILKLFN EFIQLGSDVE LICRCLFFLL RIHFGQITSN QMLVPVIEKL RETTISKVS QVRDVIGFNM AGLDYLKREC EAKSEVMFFA DATSHLEEKK RKRKKREKLI LTLT

Macromolecule #25: Transducin beta-like protein 3

• Macromolecule: Name: Transducin beta-like protein 3 / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 89.14357 KDa

Sequence

String:

MAETAAGVGR FKTNYAVERK IEPFYKGGKA QLDQTGQHLF CVCGTRVNIL EVASGAVLRS LEQEDQEDIT AFDLSPDNEV LVTASRALL LAQWAWQEGS VTRLWKAIHT APVATMAFDP TSTLLATGGC DGAVRVWDIV RHYGTHHFRG SPGVVHLVAF H PDPTRLLL FSSATDAAIR VWSLQDRSCL AVLTAHYSAV TSLAFSADGH TMLSSGRDKI CIIWDLQSCQ ATRTVPVFES VE AAVLLPE EPVSQLGVKS PGLYFLTAGD QGTLRVWEAA SGQCVYTQAQ PPGPGQELTH CTLAHTAGVV LTATADHNLL LYE ARSLRL QKQFAGYSEE VLDVRFLGPE DSHVVVASNS PCLKVFELQT SACQILHGHT DIVLALDVFR KGWLFASCAK DQSV RIWRM NKAGQVMCVA QGSGHTHSVG TVCCSRLKES FLVTGSQDCT VKLWPLPKAL LSKNTAPDNG PILLQAQTTQ RCHDK DINS VAIAPNDKLL ATGSQDRTAK LWALPQCQLL GVFSGHRRGL WCVQFSPMDQ VLATASADGT IKLWALQDFS CLKTFE GHD ASVLKVAFVS RGTQLLSSGS DGLVKLWTIK NNECVRTLDA HEDKVWGLHC SRLDDHALTG ASDSRVILWK DVTEAEQ AE EQARQEEQVV RQQELDNLLH EKRYLRALGL AISLDRPHTV LTVIQAIRRD PEACEKLEAT MLRLRRDQKE ALLRFCVT W NTNSRHCHEA QAVLGVLLRR EAPEELLAYE GVRAALEALL PYTERHFQRL SRTLQAAAFL DFLWHNMKLP VPAAAPTPW ETHKGALP

Macromolecule #26: U3 small nucleolar RNA-associated protein 18 homolog

• Macromolecule: Name: U3 small nucleolar RNA-associated protein 18 homolog / type: protein_or_peptide / ID: 26 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 62.097547 KDa

Sequence

String:

MPPERRRRMK LDRRTGAKPK RKPGMRPDWK AGAGPGGPPQ KPAPSSQRKP PARPSAAAAA IAVAAAEEER RLRQRNRLRL EEDKPAVER CLEELVFGDV ENDEDALLRR LRGPRVQEHE DSGDSEVENE AKGNFPPQKK PVWVDEEDED EEMVDMMNNR F RKDMMKNA SESKLSKDNL KKRLKEEFQH AMGGVPAWAE TTKRKTSSDD ESEEDEDDLL QRTGNFISTS TSLPRGILKM KN CQHANAE RPTVARISSV QFHPGAQIVM VAGLDNAVSL FQVDGKTNPK IQSIYLERFP IFKACFSANG EEVLATSTHS KVL YVYDML AGKLIPVHQV RGLKEKIVRS FEVSPDGSFL LINGIAGYLH LLAMKTKELI GSMKINGRVA ASTFSSDSKK VYAS SGDGE VYVWDVNSRK CLNRFVDEGS LYGLSIATSR NGQYVACGSN CGVVNIYNQD SCLQETNPKP IKAIMNLVTG VTSLT FNPT TEILAIASEK MKEAVRLVHL PSCTVFSNFP VIKNKNISHV HTMDFSPRSG YFALGNEKGK ALMYRLHHYS DF

Macromolecule #27: WD repeat-containing protein 36

• Macromolecule: Name: WD repeat-containing protein 36 / type: protein_or_peptide / ID: 27 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 105.443 KDa

Sequence

String:

MCCTEGSLRK RDSQRAPEAV LCLQLWQRTV PLDTLKGLGT CFPSGPELRG AGIAAAMERA SERRTASALF AGFRALGLFS NDIPHVVRF SALKRRFYVT TCVGKSFHTY DVQKLSLVAV SNSVPQDICC MAADGRLVFA AYGNVFSAFA RNKEIVHTFK G HKAEIHFL QPFGDHIISV DTDGILIIWH IYSEEEYLQL TFDKSVFKIS AILHPSTYLN KILLGSEQGS LQLWNVKSNK LL YTFPGWK VGVTALQQAP AVDVVAIGLM SGQVIIHNIK FNETLMKFRQ DWGPITSISF RTDGHPVMAA GSPCGHIGLW DLE DKKLIN QMRNAHSTAI AGLTFLHREP LLVTNGADNA LRIWIFDGPT GEGRLLRFRM GHSAPLTNIR YYGQNGQQIL SASQ DGTLQ SFSTVHEKFN KSLGHGLINK KRVKRKGLQN TMSVRLPPIT KFAAEEARES DWDGIIACHQ GKLSCSTWNY QKSTI GAYF LKPKELKKDD ITATAVDITS CGNFAVIGLS SGTVDVYNMQ SGIHRGSFGK DQAHKGSVRG VAVDGLNQLT VTTGSE GLL KFWNFKNKIL IHSVSLSSSP NIMLLHRDSG ILGLALDDFS ISVLDIETRK IVREFSGHQG QINDMAFSPD GRWLISA AM DCSIRTWDLP SGCLIDCFLL DSAPLNVSMS PTGDFLATSH VDHLGIYLWS NISLYSVVSL RPLPADYVPS IVMLPGTC Q TQDVEVSEET VEPSDELIEY DSPEQLNEQL VTLSLLPESR WKNLLNLDVI KKKNKPKEPP KVPKSAPFFI PTIPGLVPR YAAPEQNNDP QQSKVVNLGV LAQKSDFCLK LEEGLVNNKY DTALNLLKES GPSGIETELR SLSPDCGGSI EVMQSFLKMI GMMLDRKRD FELAQAYLAL FLKLHLKMLP SEPVLLEEIT NLSSQVEENW THLQSLFNQS MCILNYLKSA LL

Macromolecule #28: DDB1- and CUL4-associated factor 13

• Macromolecule: Name: DDB1- and CUL4-associated factor 13 / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 51.489266 KDa

Sequence

String:

MKVKMLSRNP DNYVRETKLD LQRVPRNYDP ALHPFEVPRE YIRALNATKL ERVFAKPFLA SLDGHRDGVN CLAKHPEKLA TVLSGACDG EVRIWNLTQR NCIRTIQAHE GFVRGICTRF CGTSFFTVGD DKTVKQWKMD GPGYGDEEEP LHTILGKTVY T GIDHHWKE AVFATCGQQV DIWDEQRTNP ICSMTWGFDS ISSVKFNPIE TFLLGSCASD RNIVLYDMRQ ATPLKKVILD MR TNTICWN PMEAFIFTAA NEDYNLYTFD MRALDTPVMV HMDHVSAVLD VDYSPTGKEF VSASFDKSIR IFPVDKSRSR EVY HTKRMQ HVICVKWTSD SKYIMCGSDE MNIRLWKANA SEKLGVLTSR EKAAKDYNQK LKEKFQHYPH IKRIARHRHL PKSI YSQIQ EQRIMKEARR RKEVNRIKHS KPGSVPLVSE KKKHVVAVVK

Macromolecule #29: WD repeat-containing protein 46

• Macromolecule: Name: WD repeat-containing protein 46 / type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 68.189172 KDa

Sequence

String:

METAPKPGKD VPPKKDKLQT KRKKPRRYWE EETVPTTAGA SPGPPRNKKN RELRPQRPKN AYILKKSRIS KKPQVPKKPR EWKNPESQR GLSGTQDPFP GPAPVPVEVV QKFCRIDKSR KLPHSKAKTR SRLEVAEAEE EETSIKAARS ELLLAEEPGF L EGEDGEDT AKICQADIVE AVDIASAAKH FDLNLRQFGP YRLNYSRTGR HLAFGGRRGH VAALDWVTKK LMCEINVMEA VR DIRFLHS EALLAVAQNR WLHIYDNQGI ELHCIRRCDR VTRLEFLPFH FLLATASETG FLTYLDVSVG KIVAALNARA GRL DVMSQN PYNAVIHLGH SNGTVSLWSP AMKEPLAKIL CHRGGVRAVA VDSTGTYMAT SGLDHQLKIF DLRGTYQPLS TRTL PHGAG HLAFSQRGLL VAGMGDVVNI WAGQGKASPP SLEQPYLTHR LSGPVHGLQF CPFEDVLGVG HTGGITSMLV PGAGE PNFD GLESNPYRSR KQRQEWEVKA LLEKVPAELI CLDPRALAEV DVISLEQGKK EQIERLGYDP QAKAPFQPKP KQKGRS STA SLVKRKRKVM DEEHRDKVRQ SLQQQHHKEA KAKPTGARPS ALDRFVR

Macromolecule #30: Active regulator of SIRT1

• Macromolecule: Name: Active regulator of SIRT1 / type: protein_or_peptide / ID: 30 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 15.468907 KDa

Sequence

String:

MSAALLRRGL ELLAASEAPR DPPGQAKPRG APVKRPRKTK AIQAQKLRNS AKGKVPKSAL DEYRKRECRD HLRVNLKFLT RTRSTVAES VSQQILRQNR GRKACDRPVA KTKKKKAEGT VFTEEDFQKF QQEYFGS

Macromolecule #31: U3 small nucleolar ribonucleoprotein protein IMP3

• Macromolecule: Name: U3 small nucleolar ribonucleoprotein protein IMP3 / type: protein_or_peptide / ID: 31 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 21.889227 KDa

Sequence

String:

MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREDYTRYNQ LSRAVRELAR RLRDLPERDQ FRVRASAALL DKLYALGLV PTRGSLELCD FVTASSFCRR RLPTVLLKLR MAQHLQAAVA FVEQGHVRVG PDVVTDPAFL VTRSMEDFVT W VDSSKIKR HVLEYNEERD DFDLEA

Macromolecule #32: U3 small nucleolar ribonucleoprotein protein MPP10

• Macromolecule: Name: U3 small nucleolar ribonucleoprotein protein MPP10 / type: protein_or_peptide / ID: 32 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 78.988805 KDa

Sequence

String:

MAPQVWRRRT LERCLTEVGK ATGRPECFLT IQEGLASKFT SLTKVLYDFN KILENGRIHG SPLQKLVIEN FDDEQIWQQL ELQNEPILQ YFQNAVSETI NDEDISLLPE SEEQEREEDG SEIEADDKED LEDLEEEEVS DMGNDDPEMG ERAENSSKSD L RKSPVFSD EDSDLDFDIS KLEQQSKVQN KGQGKPREKS IVDDKFFKLS EMEAYLENIE KEEERKDDND EEEEDIDFFE DI DSDEDEG GLFGSKKLKS GKSSRNLKYK DFFDPVESDE DITNVHDDEL DSNKEDDEIA EEEAEELSIS ETDEDDDLQE NED NKQHKE SLKRVTFALP DDAETEDTGV LNVKKNSDEV KSSFEKRQEK MNEKIASLEK ELLEKKPWQL QGEVTAQKRP ENSL LEETL HFDHAVRMAP VITEETTLQL EDIIKQRIRD QAWDDVVRKE KPKEDAYEYK KRLTLDHEKS KLSLAEIYEQ EYIKL NQQK TAEEENPEHV EIQKMMDSLF LKLDALSNFH FIPKPPVPEI KVVSNLPAIT MEEVAPVSVS DAALLAPEEI KEKNKA GDI KTAAEKTATD KKRERRKKKY QKRMKIKEKE KRRKLLEKSS VDQAGKYSKT VASEKLKQLT KTGKASFIKD EGKDKAL KS SQAFFSKLQD QVKMQINDAK KTEKKKKKRQ DISVHKLKL

Macromolecule #33: Something about silencing protein 10

• Macromolecule: Name: Something about silencing protein 10 / type: protein_or_peptide / ID: 33 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 54.652023 KDa

Sequence

String:

MVGRSRRRGA AKWAAVRAKA GPTLTDENGD DLGLPPSPGD TSYYQDQVDD FHEARSRAAL AKGWNEVQSG DEEDGEEEEE EVLALDMDD EDDEDGGNAG EEEEEENADD DGGSSVQSEA EASVDPSLSW GQRKKLYYDT DYGSKSRGRQ SQQEAEEEER E EEEEAQII QRRLAQALQE DDFGVAWVEA FAKPVPQVDE AETRVVKDLA KVSVKEKLKM LRKESPELLE LIEDLKVKLT EV KDELEPL LELVEQGIIP PGKGSQYLRT KYNLYLNYCS NISFYLILKA RRVPAHGHPV IERLVTYRNL INKLSVVDQK LSS EIRHLL TLKDDAVKKE LIPKAKSTKP KPKSVSKTSA AACAVTDLSD DSDFDEKAKL KYYKEIEDRQ KLKRKKEENS TEEQ ALEDQ NAKRAITYQI AKNRGLTPRR KKIDRNPRVK HREKFRRAKI RRRGQVREVR KEEQRYSGEL SGIRAGVKKS IKLK

Macromolecule #34: Nucleolar protein 7

• Macromolecule: Name: Nucleolar protein 7 / type: protein_or_peptide / ID: 34 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 29.483512 KDa

Sequence

String:

MVQLRPRASR APASAEAMVD EGQLASEEEE AEHGLLLGQP SSGAAAEPLE EDEEGDDEFD DEAPEELTFA SAQAEAREEE RRVRETVRR DKTLLKEKRK RREELFIEQK KRKLLPDTIL EKLTTASQTN IKKSPGKVKE VNLQKKNEDC EKGNDSKKVK V QKVQSVSQ NKSYLAVRLK DQDLRDSRQQ AAQAFIHNSL YGPGTNRTTV NKFLSLANKR LPVKRAAVQF LNNAWGIQKK QN AKRFKRR WMVRKMKTKK

Macromolecule #35: 40S ribosomal protein S13

• Macromolecule: Name: 40S ribosomal protein S13 / type: protein_or_peptide / ID: 35 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 17.259389 KDa

Sequence

String:

MGRMHAPGKG LSQSALPYRR SVPTWLKLTS DDVKEQIYKL AKKGLTPSQI GVILRDSHGV AQVRFVTGNK ILRILKSKGL APDLPEDLY HLIKKAVAVR KHLERNRKDK DAKFRLILIE SRIHRLARYY KTKRVLPPNW KYESSTASAL VA

Macromolecule #36: 40S ribosomal protein S14

• Macromolecule: Name: 40S ribosomal protein S14 / type: protein_or_peptide / ID: 36 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 16.302772 KDa

Sequence

String:

MAPRKGKEKK EEQVISLGPQ VAEGENVFGV CHIFASFNDT FVHVTDLSGK ETICRVTGGM KVKADRDESS PYAAMLAAQD VAQRCKELG ITALHIKLRA TGGNRTKTPG PGAQSALRAL ARSGMKIGRI EDVTPIPSDS TRRKGGRRGR RL

Macromolecule #37: Nucleolar protein 6

• Macromolecule: Name: Nucleolar protein 6 / type: protein_or_peptide / ID: 37 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 127.748641 KDa

Sequence

String:

MGPAPAGEQL RGATGEPEVM EPALEGTGKE GKKASSRKRT LAEPPAKGLL QPVKLSRAEL YKEPTNEELN RLRETEILFH SSLLRLQVE ELLKEVRLSE KKKDRIDAFL REVNQRVVRV PSVPETELTD QAWLPAGVRV PLHQVPYAVK GCFRFLPPAQ V TVVGSYLL GTCIRPDINV DVALTMPREI LQDKDGLNQR YFRKRALYLA HLAHHLAQDP LFGSVCFSYT NGCHLKPSLL LR PRGKDER LVTVRLHPCP PPDFFRPCRL LPTKNNVRSA WYRGQSPAGD GSPEPPTPRY NTWVLQDTVL ESHLQLLSTI LSS AQGLKD GVALLKVWLR QRELDKGQGG FTGFLVSMLV VFLVSTRKIH TTMSGYQVLR SVLQFLATTD LTVNGISLCL SSDP SLPAL ADFHQAFSVV FLDSSGHLNL CADVTASTYH QVQHEARLSM MLLDSRADDG FHLLLMTPKP MIRAFDHVLH LRPLS RLQA ACHRLKLWPE LQDNGGDYVS AALGPLTTLL EQGLGARLNL LAHSRPPVPE WDISQDPPKH KDSGTLTLGL LLRPEG LTS VLELGPEADQ PEAAKFRQFW GSRSELRRFQ DGAIREAVVW EAASMSQKRL IPHQVVTHLL ALHADIPETC VHYVGGP LD ALIQGLKETS STGEEALVAA VRCYDDLSRL LWGLEGLPLT VSAVQGAHPV LRYTEVFPPT PVRPAFSFYE TLRERSSL L PRLDKPCPAY VEPMTVVCHL EGSGQWPQDA EAVQRVRAAF QLRLAELLTQ QHGLQCRATA THTDVLKDGF VFRIRVAYQ REPQILKEVQ SPEGMISLRD TAASLRLERD TRQLPLLTSA LHGLQQQHPA FSGVARLAKR WVRAQLLGEG FADESLDLVA AALFLHPEP FTPPSSPQVG FLRFLFLVST FDWKNNPLFV NLNNELTVEE QVEIRSGFLA ARAQLPVMVI VTPQDRKNSV W TQDGPSAQ ILQQLVVLAA EALPMLEKQL MDPRGPGDIR TVFRPPLDIY DVLIRLSPRH IPRHRQAVDS PAASFCRGLL SQ PGPSSLM PVLGYDPPQL YLTQLREAFG DLALFFYDQH GGEVIGVLWK PTSFQPQPFK ASSTKGRMVM SRGGELVMVP NVE AILEDF AVLGEGLVQT VEARSERWTV

Macromolecule #38: Ribosomal RNA-processing protein 7 homolog A

• Macromolecule: Name: Ribosomal RNA-processing protein 7 homolog A / type: protein_or_peptide / ID: 38 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 32.39315 KDa

Sequence

String:

MVARRRKCAA RDPEDRIPSP LGYAAIPIKF SEKQQASHYL YVRAHGVRQG TKSTWPQKRT LFVLNVPPYC TEESLSRLLS TCGLVQSVE LQEKPDLAES PKESRSKFFH PKPVPGFQVA YVVFQKPSGV SAALALKGPL LVSTESHPVK SGIHKWISDY A DSVPDPEA LRVEVDTFME AYDQKIAEEE AKAKEEEGVP DEEGWVKVTR RGRRPVLPRT EAASLRVLER ERRKRSRKEL LN FYAWQHR ESKMEHLAQL RKKFEEDKQR IELLRAQRKF RPY

Macromolecule #39: Probable dimethyladenosine transferase

• Macromolecule: Name: Probable dimethyladenosine transferase / type: protein_or_peptide / ID: 39 / Number of copies: 1 / Enantiomer: LEVO; EC number: 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 35.292434 KDa

Sequence

String:

MPKVKSGAIG RRRGRQEQRR ELKSAGGLMF NTGIGQHILK NPLIINSIID KAALRPTDVV LEVGPGTGNM TVKLLEKAKK VVACELDPR LVAELHKRVQ GTPVASKLQV LVGDVLKTDL PFFDTCVANL PYQISSPFVF KLLLHRPFFR CAILMFQREF A LRLVAKPG DKLYCRLSIN TQLLARVDHL MKVGKNNFRP PPKVESSVVR IEPKNPPPPI NFQEWDGLVR ITFVRKNKTL SA AFKSSAV QQLLEKNYRI HCSVHNIIIP EDFSIADKIQ QILTSTGFSD KRARSMDIDD FIRLLHGFNA EGIHFS

Macromolecule #40: 40S ribosomal protein S3a

• Macromolecule: Name: 40S ribosomal protein S3a / type: protein_or_peptide / ID: 40 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 30.002061 KDa

Sequence

String:

MAVGKNKRLT KGGKKGAKKK VVDPFSKKDW YDVKAPAMFN IRNIGKTLVT RTQGTKIASD GLKGRVFEVS LADLQNDEVA FRKFKLITE DVQGKNCLTN FHGMDLTRDK MCSMVKKWQT MIEAHVDVKT TDGYLLRLFC VGFTKKRNNQ IRKTSYAQHQ Q VRQIRKKM MEIMTREVQT NDLKEVVNKL IPDSIGKDIE KACQSIYPLH DVFVRKVKML KKPKFELGKL MELHGEGSSS GK ATGDETG AKVERADGYE PPVQESV

Macromolecule #41: 40S ribosomal protein S15a

• Macromolecule: Name: 40S ribosomal protein S15a / type: protein_or_peptide / ID: 41 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 14.865555 KDa

Sequence

String:

MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF EIIDDHRAGK IVVNLTGRLN KCGVISPRFD VQLKDLEKW QNNLLPSRQF GFIVLTTSAG IMDHEEARRK HTGGKILGFF F

Macromolecule #42: 40S ribosomal protein S19

• Macromolecule: Name: 40S ribosomal protein S19 / type: protein_or_peptide / ID: 42 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 16.091562 KDa

Sequence

String:

MPGVTVKDVN QQEFVRALAA FLKKSGKLKV PEWVDTVKLA KHKELAPYDE NWFYTRAAST ARHLYLRGGA GVGSMTKIYG GRQRNGVMP SHFSRGSKSV ARRVLQALEG LKMVEKDQDG GRKLTPQGQR DLDRIAGQVA AANKKH

Macromolecule #43: 40S ribosomal protein S27

• Macromolecule: Name: 40S ribosomal protein S27 / type: protein_or_peptide / ID: 43 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 9.480186 KDa

Sequence

String:

MPLAKDLLHP SPEEEKRKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA QTVVLCVGCS TVLCQPTGGK ARLTEGCSFR RKQH

Macromolecule #44: RRP12-like protein

• Macromolecule: Name: RRP12-like protein / type: protein_or_peptide / ID: 44 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 73.292844 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)

Macromolecule #45: Probable ATP-dependent RNA helicase DHX37

• Macromolecule: Name: Probable ATP-dependent RNA helicase DHX37 / type: protein_or_peptide / ID: 45 / Number of copies: 1 / Enantiomer: LEVO / EC number: RNA helicase
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 129.727289 KDa

Sequence

String:

MGKLRRRYNI KGRQQAGPGP SKGPPEPPPV QLELEDKDTL KGVDASNALV LPGKKKKKTK APPLSKKEKK PLTKKEKKVL QKILEQKEK KSQRAEMLQK LSEVQASEAE MRLFYTTSKL GTGNRMYHTK EKADEVVAPG QEKISSLSGA HRKRRRWPSA E EEEEEEEE SESELEEESE LDEDPAAEPA EAGVGTTVAP LPPAPAPSSQ PVPAGMTVPP PPAAAPPLPR ALAKPAVFIP VN RSPEMQE ERLKLPILSE EQVIMEAVAE HPIVIVCGET GSGKTTQVPQ FLYEAGFSSE DSIIGVTEPR RVAAVAMSQR VAK EMNLSQ RVVSYQIRYE GNVTEETRIK FMTDGVLLKE IQKDFLLLRY KVVIIDEAHE RSVYTDILIG LLSRIVTLRA KRNL PLKLL IMSATLRVED FTQNPRLFAK PPPVIKVESR QFPVTVHFNK RTPLEDYSGE CFRKVCKIHR MLPAGGILVF LTGQA EVHA LCRRLRKAFP PSRARPQEKD DDQKDSVEEM RKFKKSRARA KKARAEVLPQ INLDHYSVLP AGEGDEDREA EVDEEE GAL DSDLDLDLGD GGQDGGEQPD ASLPLHVLPL YSLLAPEKQA QVFKPPPEGT RLCVVATNVA ETSLTIPGIK YVVDCGK VK KRYYDRVTGV SSFRVTWVSQ ASADQRAGRA GRTEPGHCYR LYSSAVFGDF EQFPPPEITR RPVEDLILQM KALNVEKV I NFPFPTPPSV EALLAAEELL IALGALQPPQ KAERVKQLQE NRLSCPITAL GRTMATFPVA PRYAKMLALS RQHGCLPYA ITIVASMTVR ELFEELDRPA ASDEELTRLK SKRARVAQMK RTWAGQGASL KLGDLMVLLG AVGACEYASC TPQFCEANGL RYKAMMEIR RLRGQLTTAV NAVCPEAELF VDPKMQPPTE SQVTYLRQIV TAGLGDHLAR RVQSEEMLED KWRNAYKTPL L DDPVFIHP SSVLFKELPE FVVYQEIVET TKMYMKGVSS VEVQWIPALL PSYCQFDKPL EEPAPTYCPE RGRVLCHRAS VF YRVGWPL PAIEVDFPEG IDRYKHFARF LLEGQVFRKL ASYRSCLLSS PGTMLKTWAR LQPRTESLLR ALVAEKADCH EAL LAAWKK NPKYLLAEYC EWLPQAMHPD IEKAWPPTTV H

Macromolecule #46: Ubiquitin-40S ribosomal protein S27a

• Macromolecule: Name: Ubiquitin-40S ribosomal protein S27a / type: protein_or_peptide / ID: 46 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 18.004041 KDa

Sequence

String:

MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGGAKKR KKKSYTTPK KNKHKRKKVK LAVLKYYKVD ENGKISRLRR ECPSDECGAG VFMASHFDRH YCGKCCLTYC FNKPEDK

Macromolecule #47: 40S ribosomal protein S17

• Macromolecule: Name: 40S ribosomal protein S17 / type: protein_or_peptide / ID: 47 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 15.578156 KDa

Sequence

String:

MGRVRTKTVK KAARVIIEKY YTRLGNDFHT NKRVCEEIAI IPSKKLRNKI AGYVTHLMKR IQRGPVRGIS IKLQEEERER RDNYVPEVS ALDQEIIEVD PDTKEMLKLL DFGSLSNLQV TQPTVGMNFK TPRGPV

Macromolecule #48: Exosome component 10

• Macromolecule: Name: Exosome component 10 / type: protein_or_peptide / ID: 48 / Number of copies: 1 / Enantiomer: LEVO; EC number: Hydrolases; Acting on ester bonds; Exoribonucleases producing 5'-phosphomonoesters
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 100.97418 KDa

Sequence

String:

MAPPSTREPR VLSATSATKS DGEMVLPGFP DADSFVKFAL GSVVAVTKAS GGLPQFGDEY DFYRSFPGFQ AFCETQGDRL LQCMSRVMQ YHGCRSNIKD RSKVTELEDK FDLLVDANDV ILERVGILLD EASGVNKNQQ PVLPAGLQVP KTVVSSWNRK A AEYGKKAK SETFRLLHAK NIIRPQLKFR EKIDNSNTPF LPKIFIKPNA QKPLPQALSK ERRERPQDRP EDLDVPPALA DF IHQQRTQ QVEQDMFAHP YQYELNHFTP ADAVLQKPQP QLYRPIEETP CHFISSLDEL VELNEKLLNC QEFAVDLEHH SYR SFLGLT CLMQISTRTE DFIIDTLELR SDMYILNESL TDPAIVKVFH GADSDIEWLQ KDFGLYVVNM FDTHQAARLL NLGR HSLDH LLKLYCNVDS NKQYQLADWR IRPLPEEMLS YARDDTHYLL YIYDKMRLEM WERGNGQPVQ LQVVWQRSRD ICLKK FIKP IFTDESYLEL YRKQKKHLNT QQLTAFQLLF AWRDKTARRE DESYGYVLPN HMMLKIAEEL PKEPQGIIAC CNPVPP LVR QQINEMHLLI QQAREMPLLK SEVAAGVKKS GPLPSAERLE NVLFGPHDCS HAPPDGYPII PTSGSVPVQK QASLFPD EK EDNLLGTTCL IATAVITLFN EPSAEDSKKG PLTVAQKKAQ NIMESFENPF RMFLPSLGHR APVSQAAKFD PSTKIYEI S NRWKLAQVQV QKDSKEAVKK KAAEQTAARE QAKEACKAAA EQAISVRQQV VLENAAKKRE RATSDPRTTE QKQEKKRLK ISKKPKDPEP PEKEFTPYDY SQSDFKAFAG NSKSKVSSQF DPNKQTPSGK KCIAAKKIKQ SVGNKSMSFP TGKSDRGFRY NWPQR

Macromolecule #49: Nucleolar protein 56

• Macromolecule: Name: Nucleolar protein 56 / type: protein_or_peptide / ID: 49 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 66.160062 KDa

Sequence

String:

MVLLHVLFEH AVGYALLALK EVEEISLLQP QVEESVLNLG KFHSIVRLVA FCPFASSQVA LENANAVSEG VVHEDLRLLL ETHLPSKKK KVLLGVGDPK IGAAIQEELG YNCQTGGVIA EILRGVRLHF HNLVKGLTDL SACKAQLGLG HSYSRAKVKF N VNRVDNMI IQSISLLDQL DKDINTFSMR VREWYGYHFP ELVKIINDNA TYCRLAQFIG NRRELNEDKL EKLEELTMDG AK AKAILDA SRSSMGMDIS AIDLINIESF SSRVVSLSEY RQSLHTYLRS KMSQVAPSLS ALIGEAVGAR LIAHAGSLTN LAK YPASTV QILGAEKALF RALKTRGNTP KYGLIFHSTF IGRAAAKNKG RISRYLANKC SIASRIDCFS EVPTSVFGEK LREQ VEERL SFYETGEIPR KNLDVMKEAM VQAEEAAAEI TRKLEKQEKK RLKKEKKRLA ALALASSENS SSTPEECEEM SEKPK KKKK QKPQEVPQEN GMEDPSISFS KPKKKKSFSK EELMSSDLEE TAGSTSIPKR KKSTPKEETV NDPEEAGHRS GSKKKR KFS KEEPVSSGPE EAVGKSSSKK KKKFHKASQE D

Macromolecule #50: Nucleolar protein 58

• Macromolecule: Name: Nucleolar protein 58 / type: protein_or_peptide / ID: 50 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 59.686332 KDa

Sequence

String:

MLVLFETSVG YAIFKVLNEK KLQEVDSLWK EFETPEKANK IVKLKHFEKF QDTAEALAAF TALMEGKINK QLKKVLKKIV KEAHEPLAV ADAKLGGVIK EKLNLSCIHS PVVNELMRGI RSQMDGLIPG VEPREMAAMC LGLAHSLSRY RLKFSADKVD T MIVQAISL LDDLDKELNN YIMRCREWYG WHFPELGKII SDNLTYCKCL QKVGDRKNYA SAKLSELLPE EVEAEVKAAA EI SMGTEVS EEDICNILHL CTQVIEISEY RTQLYEYLQN RMMAIAPNVT VMVGELVGAR LIAHAGSLLN LAKHAASTVQ ILG AEKALF RALKSRRDTP KYGLIYHASL VGQTSPKHKG KISRMLAAKT VLAIRYDAFG EDSSSAMGVE NRAKLEARLR TLED RGIRK ISGTGKALAK TEKYEHKSEV KTYDPSGDST LPTCSKKRKI EQVDKEDEIT EKKAKKAKIK VKVEEEEEEK VAEEE ETSV KKKKKRGKKK HIKEEPLSEE EPCTSTAIAS PEKKKKKKKK RENED

Macromolecule #51: rRNA 2'-O-methyltransferase fibrillarin

• Macromolecule: Name: rRNA 2'-O-methyltransferase fibrillarin / type: protein_or_peptide / ID: 51 / Number of copies: 2 / Enantiomer: LEVO; EC number: Transferases; Transferring one-carbon groups; Methyltransferases
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 33.84334 KDa

Sequence

String:

MKPGFSPRGG GFGGRGGFGD RGGRGGRGGF GGGRGRGGGF RGRGRGGGGG GGGGGGGGRG GGGFHSGGNR GRGRGGKRGN QSGKNVMVE PHRHEGVFIC RGKEDALVTK NLVPGESVYG EKRVSISEGD DKIEYRAWNP FRSKLAAAIL GGVDQIHIKP G AKVLYLGA ASGTTVSHVS DIVGPDGLVY AVEFSHRSGR DLINLAKKRT NIIPVIEDAR HPHKYRMLIA MVDVIFADVA QP DQTRIVA LNAHTFLRNG GHFVISIKAN CIDSTASAEA VFASEVKKMQ QENMKPQEQL TLEPYERDHA VVVGVYRPPP KVK N

Macromolecule #52: NHP2-like protein 1

• Macromolecule: Name: NHP2-like protein 1 / type: protein_or_peptide / ID: 52 / Number of copies: 2 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 14.191524 KDa

Sequence

String:

MTEADVNPKA YPLADAHLTK KLLDLVQQSC NYKQLRKGAN EATKTLNRGI SEFIVMAADA EPLEIILHLP LLCEDKNVPY VFVRSKQAL GRACGVSRPV IACSVTIKEG SQLKQQIQSI QQSIERLLV

Macromolecule #53: U3 small nucleolar RNA-interacting protein 2

• Macromolecule: Name: U3 small nucleolar RNA-interacting protein 2 / type: protein_or_peptide / ID: 53 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 51.920664 KDa

Sequence

String:

MSATAAARKR GKPASGAGAG AGAGKRRRKA DSAGDRGKSK GGGKMNEEIS SDSESESLAP RKPEEEEEEE LEETAQEKKL RLAKLYLEQ LRQQEEEKAE ARAFEEDQVA GRLKEDVLEQ RGRLQKLVAK EIQAPASADI RVLRGHQLSI TCLVVTPDDS A IFSAAKDC SIIKWSVESG RKLHVIPRAK KGAEGKPPGH SSHVLCMAIS SDGKYLASGD RSKLILIWEA QSCQHLYTFT GH RDAVSGL AFRRGTHQLY STSHDRSVKV WNVAENSYVE TLFGHQDAVA ALDALSRECC VTAGGRDGTV RVWKIPEESQ LVF YGHQGS IDCIHLINEE HMVSGADDGS VALWGLSKKR PLALQREAHG LRGEPGLEQP FWISSVAALL NTDLVATGSH SSCV RLWQC GEGFRQLDLL CDIPLVGFIN SLKFSSSGDF LVAGVGQEHR LGRWWRIKEA RNSVCIIPLR RVPVPPAAGS

Macromolecule #54: RNA 3'-terminal phosphate cyclase-like protein

• Macromolecule: Name: RNA 3'-terminal phosphate cyclase-like protein / type: protein_or_peptide / ID: 54 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 40.893574 KDa

Sequence

String:

MATQAHSLSY AGCNFLRQRL VLSTLSGRPV KIRKIRARDD NPGLRDFEAS FIRLLDKITN GSRIEINQTG TTLYYQPGLL YGGSVEHDC SVLRGIGYYL ESLLCLAPFM KHPLKIVLRG VTNDQVDPSV DVLKATALPL LKQFGIDGES FELKIVRRGM P PGGGGEVV FSCPVRKVLK PIQLTDPGKI KRIRGMAYSV RVSPQMANRI VDSARSILNK FIPDIYIYTD HMKGVNSGKS PG FGLSLVA ETTSGTFLSA ELASNPQGQG AAVLPEDLGR NCARLLLEEI YRGGCVDSTN QSLALLLMTL GQQDVSKVLL GPL SPYTIE FLRHLKSFFQ IMFKIETKPC GEELKGGDKV LMTCVGIGFS NLSKTLK

Macromolecule #55: Ribosome biogenesis protein BMS1 homolog

• Macromolecule: Name: Ribosome biogenesis protein BMS1 homolog / type: protein_or_peptide / ID: 55 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 146.044984 KDa

Sequence

String:

MEAKDQKKHR KKNSGPKAAK KKKRLLQDLQ LGDEEDARKR NPKAFAVQSA VRMARSFHRT QDLKTKKHHI PVVDRTPLEP PPIVVVVMG PPKVGKSTLI QCLIRNFTRQ KLTEIRGPVT IVSGKKRRLT IIECGCDINM MIDLAKVADL VLMLIDASFG F EMETFEFL NICQVHGFPK IMGVLTHLDS FKHNKQLKKT KKRLKHRFWT EVYPGAKLFY LSGMVHGEYQ NQEIHNLGRF IT VMKFRPL TWQTSHPYIL ADRMEDLTNP EDIRTNIKCD RKVSLYGYLR GAHLKNKSQI HMPGVGDFAV SDISFLPDPC ALP EQQKKR CLNEKEKLVY APLSGVGGVL YDKDAVYVDL GGSHVFQDEV GPTHELVQSL ISTHSTIDAK MASSRVTLFS DSKP LGSED IDNQGLMMPK EEKQMDLNTG RMRRKAIFGD EDESGDSDDE EDDEMSEDDG LENGSSDEEA EEEENAEMTD QYMAV KGIK RRKLELEEDS EMDLPAFADS DDDLERSSAE EGEAEEADES SEEEDCTAGE KGISGSKAAG EGSKAGLSPA NCQSDR VNL EKSLLMKKAA LPTFDSGHCT AEEVFASEDE SEESSSLSAE EEDSENEEAI RKKLSKPSQV SSGQKLGPQN FIDETSD IE NLLKEEEDYK EENNDSKETS GALKWKEDLS RKAAEAFLRQ QQAAPNLRKL IYGTVTEDNE EEDDDTLEEL GGLFRVNQ P DRECKHKADS LDCSRFLVEA PHDWDLEEVM NSIRDCFVTG KWEDDKDAAK VLAEDEELYG DFEDLETGDV HKGKSGPNT QNEDIEKEVK EEIDPDEEES AKKKHLDKKR KLKEMFDAEY DEGESTYFDD LKGEMQKQAQ LNRAEFEDQD DEARVQYEGF RPGMYVRIE IENVPCEFVQ NFDPHYPIIL GGLGNSEGNV GYVQMRLKKH RWYKKILKSR DPIIFSVGWR RFQTIPLYYI E DHNGRQRL LKYTPQHMHC GAAFWGPITP QGTGFLAIQS VSGIMPDFRI AATGVVLDLD KSIKIVKKLK LTGFPYKIFK NT SFIKGMF NSALEVAKFE GAVIRTVSGI RGQIKKALRA PEGAFRASFE DKLLMSDIVF MRTWYPVSIP AFYNPVTSLL KPV GEKDTW SGMRTTGQLR LAHGVRLKAN KDSLYKPILR QKKHFNSLHI PKALQKALPF KNKPKTQAKA GKVPKDRRRP AVIR EPHER KILALLDALS TVHSQKMKKA KEQRHLHNKE HFRAKQKEEE EKLKRQKDLR KKLFRIQGQK ERRNQKSSLK GAEGQ LQ

Macromolecule #56: Ribosomal RNA small subunit methyltransferase NEP1

• Macromolecule: Name: Ribosomal RNA small subunit methyltransferase NEP1 / type: protein_or_peptide / ID: 56 / Number of copies: 2 / Enantiomer: LEVO; EC number: Transferases; Transferring one-carbon groups; Methyltransferases
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 26.757143 KDa

Sequence

String:

MAAPSDGFKP RERSGGEQAQ DWDALPPKRP RLGAGNKIGG RRLIVVLEGA SLETVKVGKT YELLNCDKHK SILLKNGRDP GEARPDITH QSLLMLMDSP LNRAGLLQVY IHTQKNVLIE VNPQTRIPRT FDRFCGLMVQ LLHKLSVRAA DGPQKLLKVI K NPVSDHFP VGCMKVGTSF SIPVVSDVRE LVPSSDPIVF VVGAFAHGKV SVEYTEKMVS ISNYPLSAAL TCAKLTTAFE EV WGVI

Macromolecule #57: rRNA-processing protein FCF1 homolog

• Macromolecule: Name: rRNA-processing protein FCF1 homolog / type: protein_or_peptide / ID: 57 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 23.416748 KDa

Sequence

String:

MGKQKKTRKY ATMKRMLSLR DQRLKEKDRL KPKKKEKKDP SALKEREVPQ HPSCLFFQYN TQLGPPYHIL VDTNFINFSI KAKLDLVQS MMDCLYAKCI PCITDCVMAE IEKLGQKYRV ALRIAKDPRF ERLPCTHKGT YADDCLVQRV TQHKCYIVAT V DRDLKRRI RKIPGVPIMY ISNHRYNIER MPDDYGAPRF

Macromolecule #58: U3 small nucleolar ribonucleoprotein protein IMP4

• Macromolecule: Name: U3 small nucleolar ribonucleoprotein protein IMP4 / type: protein_or_peptide / ID: 58 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 33.818672 KDa

Sequence

String:

MLRREARLRR EYLYRKAREE AQRSAQERKE RLRRALEENR LIPTELRREA LALQGSLEFD DAGGEGVTSH VDDEYRWAGV EDPKVMITT SRDPSSRLKM FAKELKLVFP GAQRMNRGRH EVGALVRACK ANGVTDLLVV HEHRGTPVGL IVSHLPFGPT A YFTLCNVV MRHDIPDLGT MSEAKPHLIT HGFSSRLGKR VSDILRYLFP VPKDDSHRVI TFANQDDYIS FRHHVYKKTD HR NVELTEV GPRFELKLYM IRLGTLEQEA TADVEWRWHP YTNTARKRVF LSTE

Macromolecule #59: Small subunit processome component 20 homolog

• Macromolecule: Name: Small subunit processome component 20 homolog / type: protein_or_peptide / ID: 59 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 318.81325 KDa

Sequence

String:

MKTKPVSHKT ENTYRFLTFA ERLGNVNIDI IHRIDRTASY EEEVETYFFE GLLKWRELNL TEHFGKFYKE VIDKCQSFNQ LVYHQNEIV QSLKTHLQVK NSFAYQPLLD LVVQLARDLQ MDFYPHFPEF FLTITSILET QDTELLEWAF TSLSYLYKYL W RLMVKDMS SIYSMYSTLL AHKKLHIRNF AAESFTFLMR KVSDKNALFN LMFLDLDKHP EKVEGVGQLL FEMCKGVRNM FH SCTGQAV KLILRKLGPV TETETQLPWM LIGETLKNMV KSTVSYISKE HFGTFFECLQ ESLLDLHTKV TKTNCCESSE QIK RLLETY LILVKHGSGT KIPTPADVCK VLSQTLQVAS LSTSCWETLL DVISALILGE NVSLPETLIK ETIEKIFESR FEKR LIFSF SEVMFAMKQF EQLFLPSFLS YIVNCFLIDD AVVKDEALAI LAKLILNKAA PPTAGSMAIE KYPLVFSPQM VGFYI KQKK TRSKGRNEQF PVLDHLLSII KLPPNKDTTY LSQSWAALVV LPHIRPLEKE KVIPLVTGFI EALFMTVDKG SFGKGN LFV LCQAVNTLLS LEESSELLHL VPVERVKNLV LTFPLEPSVL LLTDLYYQRL ALCGCKGPLS QEALMELFPK LQANIST GV SKIRLLTIRI LNHFDVQLPE SMEDDGLSER QSVFAILRQA ELVPATVNDY REKLLHLRKL RHDVVQTAVP DGPLQEVP L RYLLGMLYIN FSALWDPVIE LISSHAHEME NKQFWKVYYE HLEKAATHAE KELQNDMTDE KSVGDESWEQ TQEGDVGAL YHEQLALKTD CQERLDHTNF RFLLWRALTK FPERVEPRSR ELSPLFLRFI NNEYYPADLQ VAPTQDLRRK GKGMVAEEIE EEPAAGDDE ELEEEAVPQD ESSQKKKTRR AAAKQLIAHL QVFSKFSNPR ALYLESKLYE LYLQLLLHQD QMVQKITLDC I MTYKHPHV LPYRENLQRL LEDRSFKEEI VHFSISEDNA VVKTAHRADL FPILMRILYG RMKNKTGSKT QGKSASGTRM AI VLRFLAG TQPEEIQIFL DLLFEPVRHF KNGECHSAVI QAVEDLDLSK VLPLGRQHGI LNSLEIVLKN ISHLISAYLP KIL QILLCM TATVSHILDQ REKIQLRFIN PLKNLRRLGI KMVTDIFLDW ESYQFRTEEI DAVFHGAVWP QISRLGSESQ YSPT PLLKL ISIWSRNARY FPLLAKQKPG HPECDILTNV FAILSAKNLS DATASIVMDI VDDLLNLPDF EPTETVLNLL VTGCV YPGI AENIGESITI GGRLILPHVP AILQYLSKTT ISAEKVKKKK NRAQVSKELG ILSKISKFMK DKEQSSVLIT LLLPFL HRG NIAEDTEVDI LVTVQNLLKH CVDPTSFLKP IAKLFSVIKN KLSRKLLCTV FETLSDFESG LKYITDVVKL NAFDQRH LD DINFDVRFET FQTITSYIKE MQIVDVNYLI PVMHNCFYNL ELGDMSLSDN ASMCLMSIIK KLAALNVTEK DYREIIHR S LLEKLRKGLK SQTESIQQDY TTILSCLIQT FPNQLEFKDL VQLTHYHDPE MDFFENMKHI QIHRRARALK KLAKQLMEG KVVLSSKSLQ NYIMPYAMTP IFDEKMLKHE NITTAATEII GAICKHLSWS AYMYYLKHFI HVLQTGQINQ KLGVSLLVIV LEAFHFDHK TLEEQMGKIE NEENAIEAIE LPEPEAMELE RVDEEEKEYT CKSLSDNGQP GTPDPADSGG TSAKESECIT K PVSFLPQN KEEIERTIKN IQGTITGDIL PRLHKCLAST TKREEEHKLV KSKVVNDEEV VRVPLAFAMV KLMQSLPQEV ME ANLPSIL LKVCALLKNR AQEIRDIARS TLAKIIEDLG VHFLLYVLKE LQTTLVRGYQ VHVLTFTVHM LLQGLTNKLQ VGD LDSCLD IMIEIFNHEL FGAVAEEKEV KQILSKVMEA RRSKSYDSYE ILGKFVGKDQ VTKLILPLKE ILQNTTSLKL ARKV HETLR RITVGLIVNQ EMTAESILLL SYGLISENLP LLTEKEKNPV APAPDPRLPP QSCLLLPPTP VRGGQKAVVS RKTNM HIFI ESGLRLLHLS LKTSKIKSSG ECVLEMLDPF VSLLIDCLGS MDVKVITGAL QCLIWVLRFP LPSIETKAEQ LTKHLF LLL KDYAKLGAAR GQNFHLVVNC FKCVTILVKK VKSYQITEKQ LQVLLAYAEE DIYDTSRQAT AFGLLKAILS RKLLVPE ID EVMRKVSKLA VSAQSEPARV QCRQVFLKYI LDYPLGDKLR PNLEFMLAQL NYEHETGRES TLEMIAYLFD TFPQGLLH E NCGMFFIPLC LMTINDDSAT CKKMASMTIK SLLGKISLEK KDWLFDMVTT WFGAKKRLNR QLAALICGLF VESEGVDFE KRLGTVLPVI EKEIDPENFK DIMEETEEKA ADRLLFSFLT LITKLIKECN IIQFTKPAET LSKIWSHVHS HLRHPHNWVW LTAAQIFGL LFASCQPEEL IQKWNTKKTK KHLPEPVAIK FLASDLDQKM KSISLASCHQ LHSKFLDQSL GEQVVKNLLF A AKVLYLLE LYCEDKQSKI KEDLEEQEAL EDGVACADEK AESDGEEKEE VKEELGRPAT LLWLIQKLSR IAKLEAAYSP RN PLKRTCI FKFLGAVAMD LGIDKVKPYL PMIIAPLFRE LNSTYSEQDP LLKNLSQEII ELLKKLVGLE SFSLAFASVQ KQA NEKRAL RKKRKALEFV TNPDIAAKKK MKKHKNKSEA KKRKIEFLRP GYKAKRQKSH SLKDLAMVE

Macromolecule #60: Deoxynucleotidyltransferase terminal-interacting protein 2

• Macromolecule: Name: Deoxynucleotidyltransferase terminal-interacting protein 2; type: protein_or_peptide / ID: 60 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 84.598102 KDa

Sequence

String:

MVVTRSARAK ASIQAASAES SGQKSFAANG IQAHPESSTG SDARTTAESQ TTGKQSLIPR TPKARKRKSR TTGSLPKGTE PSTDGETSE AESNYSVSEH HDTILRVTRR RQILIACSPV SSVRKKPKVT PTKESYTEEI VSEAESHVSG ISRIVLPTEK T TGARRSKA KSLTDPSQES HTEAISDAET SSSDISFSGI ATRRTRSMQR KLKAQTEKKD SKIVPGNEKQ IVGTPVNSED SD TRQTSHL QARSLSEINK PNFYNNDFDD DFSHRSSENI LTVHEQANVE SLKETKQNCK DLDEDANGIT DEGKEINEKS SQL KNLSEL QDTSLQQLVS QRHSTPQNKN AVSVHSNLNS EAVMKSLTQT FATVEVGRWN NNKKSPIKAS DLTKFGDCGG SDDE EESTV ISVSEDMNSE GNVDFECDTK LYTSAPNTSQ GKDNSVLLVL SSDESQQSEN SENEEDTLCF VENSGQRESL SGDTG SLSC DNALFVIDTT PGMSADKNFY LEEEDKASEV AIEEEKEEEE DEKSEEDSSD HDENEDEFSD EEDFLNSTKA KLLKLT SSS IDPGLSIKQL GGLYINFNAD KLQSNKRTLT QIKEKKKNEL LQKAVITPDF EKNHCVPPYS ESKYQLQKKR RKERQKT AG DGWFGMKAPE MTNELKNDLK ALKMRASMDP KRFYKKNDRD GFPKYFQIGT IVDNPADFYH SRIPKKQRKR TIVEELLA D SEFRRYNRRK YSEIMAEKAA NAAGKKFRKK KKFRN

Macromolecule #61: 40S ribosomal protein S23

• Macromolecule: Name: 40S ribosomal protein S23 / type: protein_or_peptide / ID: 61 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 15.844666 KDa

Sequence

String:

MGKCRGLRTA RKLRSHRRDQ KWHDKQYKKA HLGTALKANP FGGASHAKGI VLEKVGVEAK QPNSAIRKCV RVQLIKNGKK ITAFVPNDG CLNFIEENDE VLVAGFGRKG HAVGDIPGVR FKVVKVANVS LLALYKGKKE RPRS

Macromolecule #62: U3 small nucleolar RNA-associated protein 14 homolog A

• Macromolecule: Name: U3 small nucleolar RNA-associated protein 14 homolog A; type: protein_or_peptide / ID: 62 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 88.129125 KDa

Sequence

String:

MTANRLAESL LALSQQEELA DLPKDYLLSE SEDEGDNDGE RKHQKLLEAI SSLDGKNRRK LAERSEASLK VSEFNVSSEG SGEKLVLAD LLEPVKTSSS LATVKKQLSR VKSKKTVELP LNKEEIERIH REVAFNKTAQ VLSKWDPVVL KNRQAEQLVF P LEKEEPAI APIEHVLSGW KARTPLEQEI FNLLHKNKQP VTDPLLTPVE KASLRAMSLE EAKMRRAELQ RARALQSYYE AK ARREKKI KSKKYHKVVK KGKAKKALKE FEQLRKVNPA AALEELEKIE KARMMERMSL KHQNSGKWAK SKAIMAKYDL EAR QAMQEQ LSKNKELTQK LQVASESEEE EGGTEDVEEL LVPDVVNEVQ MNADGPNPWM LRSCTSDTKE AATQEDPEQL PELE AHGVS ESEGEERPVA EEEILLREFE ERRSLRKRSE LSQDAEPAGS QETKDSGSQE VLSELRVLSQ KLKENHQSRK QKASS EGTI PQVQREEPAP EEEEPLLLQR PERVQTLEEL EELGKEECFQ NKELPRPVLE GQQSERTPNN RPDAPKEKKK KEQMID LQN LLTTQSPSVK SLAVPTIEEL EDEEERNHRQ MIKEAFAGDD VIRDFLKEKR EAVEASKPKD VDLTLPGWGE WGGVGLK PS AKKRRRFLIK APEGPPRKDK NLPNVIINEK RNIHAAAHQV RVLPYPFTHH WQFERTIQTP IGSTWNTQRA FQKLTTPK V VTKPGHIINP IKAEDVGYRS SSRSDLSVIQ RNPKRITTRH KKQLKKCSVD

Macromolecule #63: Nucleolar protein 14

• Macromolecule: Name: Nucleolar protein 14 / type: protein_or_peptide / ID: 63 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 68.259539 KDa

Sequence

String:

MAKAKKVGAR RKASGAPAGA RGGPAKANSN PFEVKVNRQK FQILGRKTRH DVGLPGVSRA RALRKRTQTL LKEYKERDKS NVFRDK(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)TE AEL AKEEQE HLRKLEAERL RRML(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)AEGN KAKLEKLFGF LLEYVGDLAT DDPPDLTVID KLVVHLYHLC QMFPESASDA I KFVLRDAM HEMEEMIETK GRAALPGLDV LIYLKITGLL FPTSDFWHPV VTPALVCLSQ LLTKCPILSL QDVVKGLFVC CL FLEYVAL SQRFIPELIN FLLGILYIAT PNKASQGSTL VHPFRALGKN SELLVVSARE DVATWQQSSL SLRWASRLRA PTS TEANHI RLSCLAVGLA LLKRCVLMYG SLPSFHAIMG PLQALLTDHL ADCSHPQELQ ELCQSTLTEM ESQKQLCRPL TCEK SKPVP LKLFTPRLVK VLEFGRKQGS SKEEQERKRL IHKHKREFKG AVREIRKDNQ FLARMQLSEI MERDAERKRK VKQLF NSLA TQEGEWKALK RKKFKK

Macromolecule #64: Nucleolar complex protein 4 homolog

• Macromolecule: Name: Nucleolar complex protein 4 homolog / type: protein_or_peptide / ID: 64 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 50.184086 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)PRELFKLV VGGLL(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)Y DDTRYHTMQA AVDAVARVTG QHPEVPPAF WNNAFTLLSA VSLPRREPTV SSFYVKRAEL WDTWKVAHLK EHRRVFQAMW LSFLKHKLPL SLYKKVLLIV HDAILPQLAQ PTLMIDFLT RACDLGGALS LLALNGLFIL IHKHNLEYPD FYRKLYGLLD PSVFHVKYRA RFFHLADLFL SSSHLPAYLV A AFAKRLAR LALTAPPEAL LMVLPFICNL LRRHPACRVL VHRPHGPELD ADPYDPGEED PAQSRALESS LWELQALQRH YH PEVSKAA SVINQALSMP EVSIAPLLEL TAYEIFERDL KKKGPEPVPL EFIPAQGLLG RPGELCAQHF TLS

Macromolecule #65: RNA-binding protein PNO1

• Macromolecule: Name: RNA-binding protein PNO1 / type: protein_or_peptide / ID: 65 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 27.970355 KDa

Sequence

String:

MESEMETQSA RAEEGFTQVT RKGGRRAKKR QAEQLSAAGE GGDAGRMDTE EARPAKRPVF PPLCGDGLLS GKEETRKIPV PANRYTPLK ENWMKIFTPI VEHLGLQIRF NLKSRNVEIR TCKETKDVSA LTKAADFVKA FILGFQVEDA LALIRLDDLF L ESFEITDV KPLKGDHLSR AIGRIAGKGG KTKFTIENVT RTRIVLADVK VHILGSFQNI KMARTAICNL ILGNPPSKVY GN IRAVASR SADRF

Macromolecule #66: Unassigned peptides

• Macromolecule: Name: Unassigned peptides / type: protein_or_peptide / ID: 66 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 19.421865 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)

Macromolecule #67: Probable U3 small nucleolar RNA-associated protein 11

• Macromolecule: Name: Probable U3 small nucleolar RNA-associated protein 11 / type: protein_or_peptide / ID: 67 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 30.520779 KDa

Sequence

String:

MAAAFRKAAK SRQREHRERS QPGFRKHLGL LEKKKDYKLR ADDYRKKQEY LKALRKKALE KNPDEFYYKM TRVKLQDGVH IIKETKEEV TPEQLKLMRT QDVKYIEMKR VAEAKKIERL KSELHLLDFQ GKQQNKHVFF FDTKKEVEQF DVATHLQTAP E LVDRVFNR PRIETLQKEK VKGVTNQTGL KRIAKERQKQ YNCLTQRIER EKKLFVIAQK IQTRKDLMDK TQKVKVKKET VN SPAIYKF QSRRKR

Macromolecule #68: Bystin

• Macromolecule: Name: Bystin / type: protein_or_peptide / ID: 68 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Human (human)
• Molecular weight: Theoretical: 33.712934 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)PRV LEVYRGVREV LS KYRSGKL PKAFKIIPAL SNWEQILYVT EPEAWTAAAM YQATRIFASN LKERMAQRFY NLVLLPRVRD DVAEYKRLNF HLY MALKKA LFKPGAWFKG ILIPLCESGT CTLREAIIVG SIITKCSIPV LHSSAAMLKI AEMEYSGANS IFLRLLLDKK YALP YRVLD ALVFHFLGFR TEKRELPVLW HQCLLTLVQR YKADLATDQK EALLELLRLQ PHPQLSPEIR RELQSAVPRD VEDVP ITVE

Macromolecule #69: MAGNESIUM ION

• Macromolecule: Name: MAGNESIUM ION / type: ligand / ID: 69 / Number of copies: 64 / Formula: MG
• Molecular weight: Theoretical: 24.305 Da

Macromolecule #70: ADENOSINE-5'-TRIPHOSPHATE

• Macromolecule: Name: ADENOSINE-5'-TRIPHOSPHATE / type: ligand / ID: 70 / Number of copies: 1 / Formula: ATP
• Molecular weight: Theoretical: 507.181 Da

Chemical component information

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM / Adenosine triphosphate

Macromolecule #71: ZINC ION

• Macromolecule: Name: ZINC ION / type: ligand / ID: 71 / Number of copies: 3 / Formula: ZN
• Molecular weight: Theoretical: 65.409 Da

Macromolecule #72: GUANOSINE-5'-TRIPHOSPHATE

• Macromolecule: Name: GUANOSINE-5'-TRIPHOSPHATE / type: ligand / ID: 72 / Number of copies: 1 / Formula: GTP
• Molecular weight: Theoretical: 523.18 Da

Chemical component information

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM / Guanosine triphosphate

Macromolecule #73: S-ADENOSYL-L-HOMOCYSTEINE

• Macromolecule: Name: S-ADENOSYL-L-HOMOCYSTEINE / type: ligand / ID: 73 / Number of copies: 2 / Formula: SAH
• Molecular weight: Theoretical: 384.411 Da

Chemical component information

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE / S-Adenosyl-L-homocysteine

Experimental details

Structure determination

• Method: cryo EM
• Processing: single particle reconstruction
• Aggregation state: particle

Sample preparation

• Buffer: pH: 7.6
• Grid: Model: Quantifoil R2/2 / Material: GOLD / Mesh: 400 / Support film - Material: CARBON / Support film - topology: HOLEY / Support film - Film thickness: 3.0 nm / Pretreatment - Type: GLOW DISCHARGE
• Vitrification: Cryogen name: ETHANE / Chamber humidity: 90 % / Chamber temperature: 283 K / Instrument: FEI VITROBOT MARK IV

Electron microscopy

• Microscope: FEI TITAN KRIOS
• Electron beam: Acceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
• Electron optics: Illumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELDBright-field microscopy / Cs: 0.01 mm / Nominal defocus max: 2.7 µm / Nominal defocus min: 0.7000000000000001 µm
• Specialist optics: Energy filter - Slit width: 20 eV
• Sample stage: Specimen holder model: FEI TITAN KRIOS AUTOGRID HOLDER
• Image recording: Film or detector model: GATAN K3 (6k x 4k) / Number real images: 84904 / Average electron dose: 58.0 e/Ų
• Experimental equipment: Model: Titan Krios / Image courtesy: FEI Company

Image processing

• Particle selection: Number selected: 9297626
• CTF correction: Software - Name: Gctf (ver. v1.06)
• Initial angle assignment: Type: MAXIMUM LIKELIHOOD / Software - Name: RELION (ver. 3.1)
• Final 3D classification: Software - Name: RELION (ver. 3.1)
• Final angle assignment: Type: MAXIMUM LIKELIHOOD / Software - Name: RELION (ver. 3.1)
• Final reconstruction: Applied symmetry - Point group: C₁ (asymmetric) / Resolution.type: BY AUTHOR / Resolution: 2.7 Å / Resolution method: FSC 0.143 CUT-OFF / Software - Name: PHENIX (ver. 1.19) / Software - details: phenix.combine_focused_maps; Details: 15 focused maps were reconstructed in RELION 3.1 and then assembled into a unique composite map using phenix.combine_focused_maps. Two half maps were generated using each half map from the focused refinement.; Number images used: 459775

Atomic model buiding 1

Initial model

(PDB ID:

5wlc

,

6zqd

,

6zoj

,

2ipx

,

2ozb

,

4jxm

,

5fai

,

6g18

,

6g4s

,

6o16

,

6w6c

)

• Refinement: Space: REAL

Output model

PDB-7mqa:
Cryo-EM structure of the human SSU processome, state post-A1