integrase activity / Integration of viral DNA into host genomic DNA / Autointegration results in viral DNA circles / Minus-strand DNA synthesis / Plus-strand DNA synthesis / 2-LTR circle formation / Uncoating of the HIV Virion / Vpr-mediated nuclear import of PICs / Early Phase of HIV Life Cycle / Integration of provirus ...integrase activity / Integration of viral DNA into host genomic DNA / Autointegration results in viral DNA circles / Minus-strand DNA synthesis / Plus-strand DNA synthesis / 2-LTR circle formation / Uncoating of the HIV Virion / Vpr-mediated nuclear import of PICs / Early Phase of HIV Life Cycle / Integration of provirus / APOBEC3G mediated resistance to HIV-1 infection / Binding and entry of HIV virion / viral life cycle / Assembly Of The HIV Virion / HIV-1 retropepsin / retroviral ribonuclease H / exoribonuclease H / Budding and maturation of HIV virion / exoribonuclease H activity / protein processing / host multivesicular body / viral genome integration into host DNA / RNA-directed DNA polymerase / establishment of integrated proviral latency / viral penetration into host nucleus / RNA stem-loop binding / RNA-directed DNA polymerase activity / host cell / RNA-DNA hybrid ribonuclease activity / 転移酵素; リンを含む基を移すもの; 核酸を移すもの / peptidase activity / symbiont-mediated suppression of host gene expression / viral nucleocapsid / DNA recombination / DNA-directed DNA polymerase / 加水分解酵素; エステル加水分解酵素 / aspartic-type endopeptidase activity / DNA-directed DNA polymerase activity / symbiont entry into host cell / lipid binding / host cell nucleus / host cell plasma membrane / structural molecule activity / virion membrane / DNA binding / zinc ion binding / identical protein binding / membrane 類似検索 - 分子機能
THE SUBCOMPONENT CAV IN INHIBITOR 1ZK IS THE DIPEPTIDE ISOSTERE CYCLOHEXYL ALANINE PSI(CHOH-CHOH) ...THE SUBCOMPONENT CAV IN INHIBITOR 1ZK IS THE DIPEPTIDE ISOSTERE CYCLOHEXYL ALANINE PSI(CHOH-CHOH)VALINE. THE VALINE HAS A C-OH GROUP IN PLACE OF THE USUAL MAIN CHAIN N ATOM.
-
実験情報
-
実験
実験
手法: X線回折
-
試料調製
結晶
マシュー密度: 2.1 Å3/Da / 溶媒含有率: 41.56 %
結晶化
*PLUS
pH: 6.8 / 手法: 蒸気拡散法, ハンギングドロップ法
溶液の組成
*PLUS
ID
濃度
一般名
Crystal-ID
Sol-ID
1
20 %(v/v)
ammoniumsulfate
1
reservoir
2
0.1M
sodiumacetate
1
reservoir
3
10mg/ml
proteincomplex
1
drop
-
データ収集
放射
散乱光タイプ: x-ray
放射波長
相対比: 1
-
解析
ソフトウェア
名称: PROLSQ / 分類: 精密化
精密化
Rfactor obs: 0.169 / 最高解像度: 2 Å
精密化ステップ
サイクル: LAST / 最高解像度: 2 Å
タンパク質
核酸
リガンド
溶媒
全体
原子数
1516
0
59
90
1665
拘束条件
Refine-ID
タイプ
Dev ideal
Dev ideal target
X-RAY DIFFRACTION
p_bond_d
0.02
0.02
X-RAY DIFFRACTION
p_angle_d
0.049
0.035
X-RAY DIFFRACTION
p_angle_deg
X-RAY DIFFRACTION
p_planar_d
0.056
0.05
X-RAY DIFFRACTION
p_hb_or_metal_coord
X-RAY DIFFRACTION
p_mcbond_it
1.475
1.5
X-RAY DIFFRACTION
p_mcangle_it
2.21
2
X-RAY DIFFRACTION
p_scbond_it
4.215
3
X-RAY DIFFRACTION
p_scangle_it
5.934
4
X-RAY DIFFRACTION
p_plane_restr
0.017
0.02
X-RAY DIFFRACTION
p_chiral_restr
0.201
0.15
X-RAY DIFFRACTION
p_singtor_nbd
0.191
0.3
X-RAY DIFFRACTION
p_multtor_nbd
0.201
0.3
X-RAY DIFFRACTION
p_xhyhbond_nbd
0.185
0.3
X-RAY DIFFRACTION
p_xyhbond_nbd
X-RAY DIFFRACTION
p_planar_tor
2.8
3
X-RAY DIFFRACTION
p_staggered_tor
17.6
10
X-RAY DIFFRACTION
p_orthonormal_tor
17.2
20
X-RAY DIFFRACTION
p_transverse_tor
X-RAY DIFFRACTION
p_special_tor
精密化
*PLUS
最高解像度: 2 Å / 最低解像度: 10 Å / Num. reflection obs: 10110 / Rfactor obs: 0.169