+Open data
-Basic information
Entry | Database: PDB / ID: 1vbd | |||||||||
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Title | POLIOVIRUS (TYPE 1, MAHONEY STRAIN) COMPLEXED WITH R78206 | |||||||||
Components | (POLIOVIRUS TYPE 1 ...) x 5 | |||||||||
Keywords | VIRUS / VIRUS COAT PROTEIN / HYDROLASE / THIOL PROTEASE / Icosahedral virus | |||||||||
Function / homology | Function and homology information symbiont-mediated suppression of host translation initiation / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / picornain 2A / symbiont-mediated suppression of host mRNA export from nucleus / ribonucleoside triphosphate phosphatase activity / symbiont genome entry into host cell via pore formation in plasma membrane / picornain 3C / T=pseudo3 icosahedral viral capsid ...symbiont-mediated suppression of host translation initiation / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / picornain 2A / symbiont-mediated suppression of host mRNA export from nucleus / ribonucleoside triphosphate phosphatase activity / symbiont genome entry into host cell via pore formation in plasma membrane / picornain 3C / T=pseudo3 icosahedral viral capsid / host cell cytoplasmic vesicle membrane / endocytosis involved in viral entry into host cell / nucleoside-triphosphate phosphatase / protein complex oligomerization / monoatomic ion channel activity / RNA helicase activity / induction by virus of host autophagy / cysteine-type endopeptidase activity / RNA-directed RNA polymerase / viral RNA genome replication / virus-mediated perturbation of host defense response / RNA-dependent RNA polymerase activity / DNA-templated transcription / host cell nucleus / virion attachment to host cell / structural molecule activity / proteolysis / RNA binding / ATP binding / membrane / metal ion binding Similarity search - Function | |||||||||
Biological species | Human poliovirus 1 | |||||||||
Method | X-RAY DIFFRACTION / Resolution: 2.9 Å | |||||||||
Authors | Grant, R.A. / Hiremath, C.N. / Filman, D.J. / Syed, R. / Andries, K. / Hogle, J.M. | |||||||||
Citation | Journal: Curr.Biol. / Year: 1994 Title: Structures of poliovirus complexes with anti-viral drugs: implications for viral stability and drug design. Authors: Grant, R.A. / Hiremath, C.N. / Filman, D.J. / Syed, R. / Andries, K. / Hogle, J.M. #1: Journal: Acta Crystallogr.,Sect.D / Year: 1995 Title: Binding of the Antiviral Drug Win51711 to the Sabin Strain of Type 3 Poliovirus: Structural Comparison with Drug Binding in Rhinovirus 14 Authors: Hiremath, C.N. / Grant, R.A. / Filman, D.J. / Hogle, J.M. #2: Journal: New Aspects of Positive-Strand RNA Viruses / Year: 1990 Title: Role of Conformational Transitions in Poliovirus Assembly and Cell Entry Authors: Hogle, J.M. / Syed, R. / Fricks, C.E. / Icenogle, J.P. / Flore, O. / Filman, D.J. #3: Journal: Embo J. / Year: 1989 Title: Structural Factors that Control Conformational Transitions and Serotype Specificity in Type 3 Poliovirus Authors: Filman, D.J. / Syed, R. / Chow, M. / Macadam, A.J. / Minor, P.D. / Hogle, J.M. #4: Journal: Nature / Year: 1987 Title: Myristylation of Picornavirus Capsid Protein Vp4 and its Structural Significance Authors: Chow, M. / Newman, J.F. / Filman, D. / Hogle, J.M. / Rowlands, D.J. / Brown, F. #5: Journal: Science / Year: 1985 Title: Three-Dimensional Structure of Poliovirus at 2.9 A Resolution Authors: Hogle, J.M. / Chow, M. / Filman, D.J. #6: Journal: Nucleic Acids Res. / Year: 1983 Title: The Nucleotide Sequence of Poliovirus Type 3 Leon 12 A1B: Comparison with Poliovirus Type 1 Authors: Stanway, G. / Cann, A.J. / Hauptmann, R. / Hughes, P. / Clarke, L.D. / Mountford, R.C. / Minor, P.D. / Schild, G.C. / Almond, J.W. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1vbd.cif.gz | 175.6 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1vbd.ent.gz | 141.1 KB | Display | PDB format |
PDBx/mmJSON format | 1vbd.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1vbd_validation.pdf.gz | 480 KB | Display | wwPDB validaton report |
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Full document | 1vbd_full_validation.pdf.gz | 493.8 KB | Display | |
Data in XML | 1vbd_validation.xml.gz | 19.1 KB | Display | |
Data in CIF | 1vbd_validation.cif.gz | 28.8 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/vb/1vbd ftp://data.pdbj.org/pub/pdb/validation_reports/vb/1vbd | HTTPS FTP |
-Related structure data
-Links
-Assembly
Deposited unit |
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1 |
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2 |
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3 |
| x 5|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
4 |
| x 6|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
5 |
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6 |
| x 30|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Unit cell |
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Symmetry | Point symmetry: (Hermann–Mauguin notation: 532 / Schoenflies symbol: I (icosahedral)) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Noncrystallographic symmetry (NCS) | NCS oper:
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