macrophage elastase / negative regulation of endothelial cell-matrix adhesion via fibronectin / bronchiole development / positive regulation of epithelial cell proliferation involved in wound healing / elastin catabolic process / regulation of defense response to virus by host / positive regulation of type I interferon-mediated signaling pathway / wound healing, spreading of epidermal cells / negative regulation of type I interferon-mediated signaling pathway / lung alveolus development ...macrophage elastase / negative regulation of endothelial cell-matrix adhesion via fibronectin / bronchiole development / positive regulation of epithelial cell proliferation involved in wound healing / elastin catabolic process / regulation of defense response to virus by host / positive regulation of type I interferon-mediated signaling pathway / wound healing, spreading of epidermal cells / negative regulation of type I interferon-mediated signaling pathway / lung alveolus development / response to amyloid-beta / Collagen degradation / collagen catabolic process / extracellular matrix disassembly / positive regulation of interferon-alpha production / core promoter sequence-specific DNA binding / collagen binding / Degradation of the extracellular matrix / extracellular matrix organization / extracellular matrix / cellular response to virus / metalloendopeptidase activity / protein import into nucleus / endopeptidase activity / sequence-specific DNA binding / serine-type endopeptidase activity / calcium ion binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / proteolysis / extracellular space / zinc ion binding / extracellular region / nucleus / cytoplasm 類似検索 - 分子機能
OUR DYNAMIC LIGHT SCATTERING EXPERIMENTS HAVE SHOWN THATTHE PROTEIN EXISTS AS A MONOMER IN SOLUTION, SUGGESTINGTHAT THE HEXAMER DESCRIBED IN REMARK 350 IS AN ARTIFACTOF CRYSTALLIZATION ONLY. THE PROTEIN IS KNOWN TO FUNCTIONAS A MONOMER
分子量: 17631.648 Da / 分子数: 1 / 断片: CATALYTIC DOMAIN, RESIDUES 106-264 / 由来タイプ: 組換発現 詳細: COMPLEXED WITH A SMALL MOLECULE INHIBITOR 2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHYL-4-(4-ETHOXY[1,1-BIPHENYL]-4-YL)-4-OXOBUTANOIC ACID FORMULA C19H19N2O4S, AND ALSO WITH ACETOHYDROXAMIC ...詳細: COMPLEXED WITH A SMALL MOLECULE INHIBITOR 2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHYL-4-(4-ETHOXY[1,1-BIPHENYL]-4-YL)-4-OXOBUTANOIC ACID FORMULA C19H19N2O4S, AND ALSO WITH ACETOHYDROXAMIC ACID OR 2-HYDROXYAMINO-2-ETHANAL FORMULA, C2H5NO2 由来: (組換発現) HOMO SAPIENS (ヒト) / プラスミド: PGEMEX1 / 発現宿主: ESCHERICHIA COLI (大腸菌) / 株 (発現宿主): BL21(DE3) / 参照: UniProt: P39900, macrophage elastase
MAY BE INVOLVED IN TISSUE INJURY AND REMODELING. HAS SIGNIFICANT ELASTOLYTIC ACTIVITY. BINDS 2 ZINC ...MAY BE INVOLVED IN TISSUE INJURY AND REMODELING. HAS SIGNIFICANT ELASTOLYTIC ACTIVITY. BINDS 2 ZINC IONS AND 4 CALCIUM IONS PER SUBUNIT. FOUND IN ALVEOLAR MACROPHAGES BUT NOT IN PERIPHERAL BLOOD MONOCYTES.