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-Structure paper
Title | Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders |
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Journal, issue, pages | To Be Published |
Publish date | Oct 23, 2023 (structure data deposition date) |
![]() | Miotto MC |
![]() | Search PubMed |
Methods | EM (single particle) |
Resolution | 2.79 - 5.65 Å |
Structure data | EMDB-42458, PDB-8uq2: EMDB-42459, PDB-8uq3: EMDB-42460, PDB-8uq4: EMDB-42461, PDB-8uq5: ![]() EMDB-42505: Raw consensus map of the Structure of human RyR2-S2808D in the subprimed state ![]() EMDB-42581: Constituent EM map: Focused refinement TaF+TM+CTD of the Structure of human RyR2-S2808D in the subprimed state ![]() EMDB-42582: Constituent EM map: Focused refinement Jsol+CSol of the Structure of human RyR2-S2808D in the subprimed state ![]() EMDB-42583: Constituent EM map: Focused refinement NTD+SPRY+Calstabin-2 of the Structure of human RyR2-S2808D in the subprimed state ![]() EMDB-42584: Constituent EM map: Focused refinement RY3&4 of the Structure of human RyR2-S2808D in the subprimed state ![]() EMDB-42585: Constituent EM map: Focused refinement RY1&2 of the Structure of human RyR2-S2808D in the subprimed state ![]() EMDB-42586: Constituent EM map: Focused refinement BSol2 of the Structure of human RyR2-S2808D in the subprimed state ![]() EMDB-42703: Raw consensus map of the Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 ![]() EMDB-42704: Constituent EM map: Focused refinement TaF+TM+CTD of the Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 ![]() EMDB-42705: Constituent EM map: Focused refinement Jsol+CSol of the Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 ![]() EMDB-42706: Constituent EM map: Focused refinement NTD+SPRY+Calstabin-2 of the Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 ![]() EMDB-42707: Constituent EM map: Focused refinement BSol of the Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 ![]() EMDB-42708: Constituent EM map: Focused refinement RY1&2 of the Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 ![]() EMDB-42709: Constituent EM map: Focused refinement RY3&4 of the Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 ![]() EMDB-42710: Constituent EM map: Focused refinement BSol2 of the Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 ![]() EMDB-42711: Raw consensus map of the Structure of PKA phosphorylated human RyR2-R420W in the primed state ![]() EMDB-42712: Constituent EM map: Focused refinement TaF+TM+CTD of the Structure of PKA phosphorylated human RyR2-R420W in the primed state ![]() EMDB-42713: Constituent EM map: Focused refinement Jsol+CSol of the Structure of PKA phosphorylated human RyR2-R420W in the primed state ![]() EMDB-42715: Constituent EM map: Focused refinement NTD+SPRY+Calstabin-2 of the Structure of PKA phosphorylated human RyR2-R420W in the primed state ![]() EMDB-42716: Constituent EM map: Focused refinement RY1&2 of the Structure of PKA phosphorylated human RyR2-R420W in the primed state ![]() EMDB-42717: Constituent EM map: Focused refinement RY3&4 of the Structure of PKA phosphorylated human RyR2-R420W in the primed state ![]() EMDB-42718: Constituent EM map: Focused refinement BSol2 of the Structure of PKA phosphorylated human RyR2-R420W in the primed state ![]() EMDB-42722: Raw consensus map of the Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 ![]() EMDB-42723: Constituent EM map: Focused refinement TaF+TM+CTD of the Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 ![]() EMDB-42724: Constituent EM map: Focused refinement Jsol+CSol of the Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 ![]() EMDB-42725: Constituent EM map: Focused refinement NTD+SPRY+Calstabin-2 of the Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 ![]() EMDB-42726: Constituent EM map: Focused refinement RY1&2 of the Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 ![]() EMDB-42727: Constituent EM map: Focused refinement RY3&4 of the Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 ![]() EMDB-42728: Constituent EM map: Focused refinement BSol2 of the Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 ![]() EMDB-42729: Raw consensus map of the Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium ![]() EMDB-42730: Constituent EM map: Focused refinement TaF+TM+CTD of the Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium ![]() EMDB-42731: Constituent EM map: Focused refinement Jsol+CSol of the Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium ![]() EMDB-42732: Constituent EM map: Focused refinement NTD+SPRY+Calstabin-2 of the Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium ![]() EMDB-42733: Constituent EM map: Focused refinement RY1&2 of the Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium ![]() EMDB-42734: Constituent EM map: Focused refinement RY3&4 of the Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium ![]() EMDB-42735: Constituent EM map: Focused refinement BSol2 of the Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium ![]() EMDB-42736: Raw consensus map of the Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium ![]() EMDB-42737: Constituent EM map: Focused refinement TaF+TM+CTD of the Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium ![]() EMDB-42738: Constituent EM map: Focused refinement JSol+CSol of the Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium ![]() EMDB-42739: Constituent EM map: Focused refinement NTD+SPRY+Calstabin-2 of the Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium ![]() EMDB-42740: Constituent EM map: Focused refinement RY1&2 of the Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium ![]() EMDB-42741: Constituent EM map: Focused refinement RY3&4 of the Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium ![]() EMDB-42742: Constituent EM map: Focused refinement BSol2 of the Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium EMDB-42759, PDB-8uxc: EMDB-42761, PDB-8uxe: EMDB-42762, PDB-8uxf: EMDB-42763, PDB-8uxg: EMDB-42764, PDB-8uxh: EMDB-42765, PDB-8uxi: EMDB-42768, PDB-8uxl: EMDB-42769, PDB-8uxm: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-ATP: ![]() ChemComp-KVR: ![]() ChemComp-CA: |
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