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Structure paper

TitleStructures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 110, Page 15180-15188, Year 2013
Publish dateMay 8, 2013 (structure data deposition date)
AuthorsWibowo, A.S. / Singh, M. / Reeder, K.M. / Carter, J.J. / Kovach, A.R. / Meng, W. / Ratnam, M. / Zhang, F. / Dann, C.E.
External linksProc. Natl. Acad. Sci. USA / PubMed:23934049
MethodsX-ray diffraction
Resolution1.55 - 2.6 Å
Structure data

PDB-4km6:
Human folate receptor alpha (FOLR1) at acidic pH, orthorhombic form
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-4km7:
Human folate receptor alpha (FOLR1) at acidic pH, triclinic form
Method: X-RAY DIFFRACTION / Resolution: 1.801 Å

PDB-4kmx:
Human folate receptor alpha (FOLR1) at acidic pH, hexagonal form
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-4kmy:
Human folate receptor beta (FOLR2) at neutral pH
Method: X-RAY DIFFRACTION / Resolution: 1.795 Å

PDB-4kmz:
Human folate receptor beta (FOLR2) in complex with the folate
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-4kn0:
Human folate receptor beta (FOLR2) in complex with the antifolate methotrexate
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-4kn1:
Human folate receptor beta (FOLR2) in complex with the antifolate aminopterin
Method: X-RAY DIFFRACTION / Resolution: 2.301 Å

PDB-4kn2:
Human folate receptor beta (FOLR2) in complex with antifolate pemetrexed
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-K:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-FOL:
FOLIC ACID

ChemComp-MTX:
METHOTREXATE

ChemComp-04J:
Aminopterin / chemotherapy, antineoplastic*YM

ChemComp-LYA:
2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Folate Receptor Alpha / FOLR1 / folate receptor / Folic acid / folates / 5-methyltetrahydrofolate / antifolates / folate-conjugates / GPI-anchored protein on eukaryotic membrane / TRANSPORT PROTEIN / Folate Receptor Beta / FOLR2 / GPI-anchor membrane receptor

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