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Structure paper

TitleCryo-EM reconstruction of PI3KC3-C2 in complex with Rubicon Middle Region of C terminus
Journal, issue, pagesTo Be Published
Publish dateDec 16, 2025 (structure data deposition date)
AuthorsChen M / Joiner A / Hurley JH
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.26 - 3.83 Å
Structure data

EMDB-74509: Cryo-EM reconstruction of human PI3KC3-C2, focused map 1/2
Method: EM (single particle) / Resolution: 3.38 Å

EMDB-74510: Cryo-EM reconstruction of human PI3KC3-C2, focused map 2/2
Method: EM (single particle) / Resolution: 3.5 Å

EMDB-74511: Cryo-EM composite map of human PI3KC3-C2
Method: EM (single particle) / Resolution: 3.38 Å

EMDB-74520: Cryo-EM reconstruction of PI3KC3-C2 in complex with Rubicon Middle Region of C terminus, focused map 1/2
Method: EM (single particle) / Resolution: 3.35 Å

EMDB-74521: Cryo-EM reconstruction of PI3KC3-C2 in complex with Rubicon Middle Region of C terminus, focused map 2/2
Method: EM (single particle) / Resolution: 3.38 Å

EMDB-74522: Cryo-EM reconstruction of PI3KC3-C2 in complex with Rubicon Middle Region of C terminus, composite map
Method: EM (single particle) / Resolution: 3.35 Å

74526

9zpc

EMDB-74526, PDB-9zpc:
Cryo-EM structure of human PI3KC3-C2
Method: EM (single particle) / Resolution: 3.83 Å

74527

9zpd

EMDB-74527, PDB-9zpd:
Cryo-EM structure of human PI3KC3-C2 in complex with Rubicon Middle Region of C terminus
Method: EM (single particle) / Resolution: 3.38 Å

EMDB-76932: Cryo-EM reconstruction of human PI3KC3-C1, focused map 1/2
Method: EM (single particle) / Resolution: 3.29 Å

EMDB-76933: Cryo-EM reconstruction of human PI3KC3-C1, focused map 2/2
Method: EM (single particle) / Resolution: 3.26 Å

76934

13bv

EMDB-76934: Cryo-EM reconstruction of human PI3KC3-C1, composite map
PDB-13bv: Cryo-EM structure of human PI3KC3-C1 complex
Method: EM (single particle) / Resolution: 3.26 Å

EMDB-76952: Consensus cryo-EM map for the structure of human PI3KC3-C1 complex
Method: EM (single particle) / Resolution: 3.77 Å

Chemicals

ChemComp-MYR:
MYRISTIC ACID

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Lipid kinase / autophagosome formation / signaling protein / endocytic sorting / cytokinesis / autophagosome maturation / lysosome recycling / LC3-associated phagocytosis

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