タイトル | Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis |
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ジャーナル・号・ページ | Fundam Res, Year 2024 |
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掲載日 | 2023年7月31日 (構造データの登録日) |
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著者 | Li M / Liu H / Hsieh KY / Zhang S / Gao Y / Gong Q / Zhang K / Chang CI / Li S |
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リンク | Fundam Res / PubMedで検索 |
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手法 | EM (単粒子) |
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解像度 | 2.54 - 4.5 Å |
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構造データ | EMDB-36965, PDB-8k8v: CryoEM structure of LonC protease hepatmer, apo state 手法: EM (単粒子) / 解像度: 2.75 Å EMDB-36966, PDB-8k8w: CryoEM structure of LonC protease open hexamer, apo state 手法: EM (単粒子) / 解像度: 3.46 Å EMDB-36968, PDB-8k8y: CryoEM structure of LonC heptamer in presence of AGS 手法: EM (単粒子) / 解像度: 2.54 Å EMDB-36969, PDB-8k8z: CryoEM structure of LonC protease hexamer in presence of AGS 手法: EM (単粒子) / 解像度: 2.83 Å EMDB-36970, PDB-8k90: CryoEM structure of LonC protease open pentamer in presence of AGS 手法: EM (単粒子) / 解像度: 3.43 Å EMDB-36971, PDB-8k91: CryoEM structure of LonC S582A hepatmer with Lysozyme 手法: EM (単粒子) / 解像度: 3.03 Å EMDB-36972, PDB-8k92: CryoEM structure of LonC S582A hexamer with Lysozyme 手法: EM (単粒子) / 解像度: 3.31 Å EMDB-36973, PDB-8k93: CryoEM structure of LonC protease S582A open hexamer with lysozyme 手法: EM (単粒子) / 解像度: 3.23 Å EMDB-36974, PDB-8k94: CryoEM structure of LonC protease S582A open pentamer with lysozyme 手法: EM (単粒子) / 解像度: 3.4 Å EMDB-36975, PDB-8k95: CryoEM structure of LonC protease open Hexamer, AGS 手法: EM (単粒子) / 解像度: 3.05 Å EMDB-36976, PDB-8k96: CryoEM structure of LonC protease hepatmer with Bortezomib 手法: EM (単粒子) / 解像度: 2.89 Å EMDB-36977, PDB-8k97: CryoEM structure of LonC protease hexamer with Bortezomib 手法: EM (単粒子) / 解像度: 2.73 Å EMDB-36978: CryoEM map of LonC protease open hexamer with Bortezomib 手法: EM (単粒子) / 解像度: 4.5 Å EMDB-36979: CryoEM map of LonC protease heptamer (heated at 343K) 手法: EM (単粒子) / 解像度: 3.65 Å |
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化合物 | ChemComp-BO2: N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE / ボルテゾミブ / 薬剤, 抗がん剤*YM
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由来 | - meiothermus taiwanensis (バクテリア)
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キーワード | CHAPERONE / Lon proteases / hepatmer / open hexamer / open pentamer / heptamer / AGS / hexatmer / Lysozyme / hexamer / inhibitor |
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