EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
ジャーナル・号・ページ	Chem. Biol., Vol. 7, Page 299-312, Year 2000
掲載日	1999年12月22日 (構造データの登録日)
著者	Katz, B.A. / Mackman, R. / Luong, C. / Radika, K. / Martelli, A. / Sprengeler, P.A. / Wang, J. / Chan, H. / Wong, L.
リンク	Chem. Biol. / PubMed:10779411
手法	X線回折
解像度	1.36 - 1.95 Å
構造データ	PDB-1c5l: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 手法: X-RAY DIFFRACTION / 解像度: 1.47 Å PDB-1c5m: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-1c5n: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-1c5o: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-1c5p: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 手法: X-RAY DIFFRACTION / 解像度: 1.43 Å PDB-1c5q: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 手法: X-RAY DIFFRACTION / 解像度: 1.43 Å PDB-1c5r: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 手法: X-RAY DIFFRACTION / 解像度: 1.47 Å PDB-1c5s: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 手法: X-RAY DIFFRACTION / 解像度: 1.36 Å PDB-1c5t: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 手法: X-RAY DIFFRACTION / 解像度: 1.37 Å PDB-1c5u: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 手法: X-RAY DIFFRACTION / 解像度: 1.37 Å PDB-1c5v: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 手法: X-RAY DIFFRACTION / 解像度: 1.48 Å PDB-1c5w: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 手法: X-RAY DIFFRACTION / 解像度: 1.94 Å PDB-1c5x: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-1c5y: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 手法: X-RAY DIFFRACTION / 解像度: 1.65 Å PDB-1c5z: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å
化合物	ChemComp-NA: Unknown entry / ナトリウムカチオン ChemComp-CA: Unknown entry / カルシウムジカチオン ChemComp-HOH: WATER ChemComp-ESI: 4-IODOBENZO[B]THIOPHENE-2-CARBOXAMIDINE ChemComp-BEN: BENZAMIDINE / ベンズアミジン ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-SO4: SULFATE ION / 硫酸ジアニオン ChemComp-CL: Unknown entry / クロリド ChemComp-FLC: CITRATE ANION / シトラ-ト ChemComp-ESX: BENZO[B]THIOPHENE-2-CARBOXAMIDINE ChemComp-ESP: THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDINE
由来	homo sapiens (ヒト) hirudo medicinalis (医用ビル) bos taurus (ウシ)
キーワード	BLOOD CLOTTING/HYDROLASE INHIBITOR / selective / S1 site inhibitor / structure-based drug design / urokinase / trypsin / thrombin / BLOOD CLOTTING-HYDROLASE INHIBITOR COMPLEX / BLOOD CLOTTING / HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex / HYDROLASE