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Structure paper

TitleEffects of HLA single chain trimer design on peptide presentation and stability.
Journal, issue, pagesFront Immunol, Vol. 14, Page 1170462-1170462, Year 2023
Publish dateNov 5, 2021 (structure data deposition date)
AuthorsFinton, K.A.K. / Rupert, P.B. / Friend, D.J. / Dinca, A. / Lovelace, E.S. / Buerger, M. / Rusnac, D.V. / Foote-McNabb, U. / Chour, W. / Heath, J.R. ...Finton, K.A.K. / Rupert, P.B. / Friend, D.J. / Dinca, A. / Lovelace, E.S. / Buerger, M. / Rusnac, D.V. / Foote-McNabb, U. / Chour, W. / Heath, J.R. / Campbell, J.S. / Pierce, R.H. / Strong, R.K.
External linksFront Immunol / PubMed:37207206
MethodsX-ray diffraction
Resolution2.35 - 2.78 Å
Structure data

PDB-7sqp:
Single chain trimer HLA-A*02:01 (Y108C) with HPV.16 E7 peptide YMLDLQPETTDL
Method: X-RAY DIFFRACTION / Resolution: 2.53 Å

PDB-7sr0:
Single chain trimer HLA-A*02:01 (H98L, Y108C) with HPV.16 E7 peptide YMLDLQPET
Method: X-RAY DIFFRACTION / Resolution: 2.54 Å

PDB-7sr3:
Single chain trimer HLA-A*02:01 (H98L, Y108C) with HPV.16 E7 peptide YMLDLQPETTDL
Method: X-RAY DIFFRACTION / Resolution: 2.49 Å

PDB-7sr4:
Single chain trimer HLA-A*02:01 (H98L, Y108C) with HPV.16 E7 peptide YMLDLQPETTDLYC
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

PDB-7sr5:
Single chain trimer HLA-A*02:01 (Y108C, A163C) with Wilms tumor protein peptide RMFPNAPYL
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-7srk:
Single chain trimer HLA-A*24:02 (Y108C, A163C) with 8mer peptide YPPVPETF
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-7ssh:
Single chain trimer HLA-A*02:01 (Y108A) with HPV.16 E7 peptide YMLDLQPETTDLYC
Method: X-RAY DIFFRACTION / Resolution: 2.73 Å

PDB-7st3:
Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity
Method: X-RAY DIFFRACTION / Resolution: 2.78 Å

PDB-7stg:
Consequences of HLA single chain trimer mutations on peptide presentation and binding affinity
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

Source
  • human papillomavirus type 16
  • pongo pygmaeus (Bornean orangutan)
  • homo sapiens (human)
  • lama glama (llama)
KeywordsIMMUNE SYSTEM / HLA / VHH / HPV / SCT / IMMUNE SYSTEM/VIRAL PROTEIN / IMMUNE SYSTEM-VIRAL PROTEIN complex

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