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- PDB-7sr0: Single chain trimer HLA-A*02:01 (H98L, Y108C) with HPV.16 E7 pept... -

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ID or keywords:

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Basic information

Entry
Database: PDB / ID: 7sr0
TitleSingle chain trimer HLA-A*02:01 (H98L, Y108C) with HPV.16 E7 peptide YMLDLQPET
Components
  • Protein E7 peptide,Beta-2-microglobulin,MHC class I antigen chimera
  • VHH
KeywordsIMMUNE SYSTEM / HLA / VHH / HPV / SCT
Function / homology
Function and homology information


symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity / symbiont-mediated suppression of host cGAS-STING signal transduction / symbiont-mediated perturbation of host transcription / symbiont-mediated perturbation of host cell cycle progression / symbiont-mediated suppression of host apoptosis / positive regulation of actin filament polymerization / cadmium ion binding / symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint / antigen processing and presentation of peptide antigen via MHC class I / viral process ...symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host IRF9 activity / symbiont-mediated suppression of host cGAS-STING signal transduction / symbiont-mediated perturbation of host transcription / symbiont-mediated perturbation of host cell cycle progression / symbiont-mediated suppression of host apoptosis / positive regulation of actin filament polymerization / cadmium ion binding / symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint / antigen processing and presentation of peptide antigen via MHC class I / viral process / lumenal side of endoplasmic reticulum membrane / ER to Golgi transport vesicle membrane / MHC class I protein complex / phagocytic vesicle membrane / recycling endosome membrane / early endosome membrane / DNA-binding transcription factor binding / host cell cytoplasm / immune response / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / DNA-binding transcription factor activity / protein domain specific binding / DNA-templated transcription / host cell nucleus / cell surface / DNA binding / extracellular region / zinc ion binding
Similarity search - Function
Papillomavirus E7 / E7 protein, Early protein / MHC class I, alpha chain, C-terminal / MHC_I C-terminus / MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 / Beta-2-Microglobulin / : / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily ...Papillomavirus E7 / E7 protein, Early protein / MHC class I, alpha chain, C-terminal / MHC_I C-terminus / MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 / Beta-2-Microglobulin / : / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold / Immunoglobulins / Immunoglobulin-like / Sandwich / Mainly Beta
Similarity search - Domain/homology
PHOSPHATE ION / MHC class I antigen / Protein E7 / Beta-2-microglobulin
Similarity search - Component
Biological speciesHuman papillomavirus type 16
Pongo pygmaeus (Bornean orangutan)
Homo sapiens (human)
Lama glama (llama)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.54 Å
AuthorsFinton, K.A.K. / Rupert, P.B.
Funding support United States, 1items
OrganizationGrant numberCountry
National Institutes of Health/National Cancer Institute (NIH/NCI) United States
CitationJournal: Front Immunol / Year: 2023
Title: Effects of HLA single chain trimer design on peptide presentation and stability.
Authors: Finton, K.A.K. / Rupert, P.B. / Friend, D.J. / Dinca, A. / Lovelace, E.S. / Buerger, M. / Rusnac, D.V. / Foote-McNabb, U. / Chour, W. / Heath, J.R. / Campbell, J.S. / Pierce, R.H. / Strong, R.K.
History
DepositionNov 7, 2021Deposition site: RCSB / Processing site: RCSB
Revision 1.0Nov 23, 2022Provider: repository / Type: Initial release
Revision 1.1May 31, 2023Group: Database references / Category: citation / citation_author
Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year
Revision 1.2Oct 25, 2023Group: Data collection / Refinement description
Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
Revision 1.3Nov 13, 2024Group: Structure summary / Category: pdbx_entry_details / pdbx_modification_feature / Item: _pdbx_entry_details.has_protein_modification

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Protein E7 peptide,Beta-2-microglobulin,MHC class I antigen chimera
B: VHH
C: Protein E7 peptide,Beta-2-microglobulin,MHC class I antigen chimera
D: VHH
hetero molecules


Theoretical massNumber of molelcules
Total (without water)120,6086
Polymers120,4194
Non-polymers1902
Water2,864159
1
A: Protein E7 peptide,Beta-2-microglobulin,MHC class I antigen chimera
B: VHH
hetero molecules


Theoretical massNumber of molelcules
Total (without water)60,3043
Polymers60,2092
Non-polymers951
Water362
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
C: Protein E7 peptide,Beta-2-microglobulin,MHC class I antigen chimera
D: VHH
hetero molecules


Theoretical massNumber of molelcules
Total (without water)60,3043
Polymers60,2092
Non-polymers951
Water362
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)117.713, 117.713, 261.836
Angle α, β, γ (deg.)90.000, 90.000, 90.000
Int Tables number92
Space group name H-MP41212
Space group name HallP4abw2nw
Symmetry operation#1: x,y,z
#2: -y+1/2,x+1/2,z+1/4
#3: y+1/2,-x+1/2,z+3/4
#4: x+1/2,-y+1/2,-z+3/4
#5: -x+1/2,y+1/2,-z+1/4
#6: -x,-y,z+1/2
#7: y,x,-z
#8: -y,-x,-z+1/2

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Components

#1: Protein Protein E7 peptide,Beta-2-microglobulin,MHC class I antigen chimera


Mass: 47672.453 Da / Num. of mol.: 2 / Mutation: H98L, Y108C
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Human papillomavirus type 16, (gene. exp.) Pongo pygmaeus (Bornean orangutan), (gene. exp.) Homo sapiens (human)
Gene: E7, B2M, HLA-A / Cell line (production host): HEK 293 F / Production host: Homo sapiens (human)
References: UniProt: P03129, UniProt: P16213, UniProt: A0A678ZGP6
#2: Antibody VHH


Mass: 12536.822 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Lama glama (llama) / Production host: Homo sapiens (human)
#3: Chemical ChemComp-PO4 / PHOSPHATE ION


Mass: 94.971 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: PO4
#4: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 159 / Source method: isolated from a natural source / Formula: H2O
Has ligand of interestN
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 3.77 Å3/Da / Density % sol: 67.34 %
Crystal growTemperature: 295 K / Method: vapor diffusion, hanging drop / Details: 200 mM HK2PO4, 20% PEG 3350

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Data collection

DiffractionMean temperature: 93 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: ALS / Beamline: 5.0.1 / Wavelength: 1 Å
DetectorType: DECTRIS PILATUS 6M / Detector: PIXEL / Date: Oct 7, 2020
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1 Å / Relative weight: 1
ReflectionResolution: 2.54→50 Å / Num. obs: 59905 / % possible obs: 97.6 % / Redundancy: 11 % / Biso Wilson estimate: 47.54 Å2 / CC1/2: 0.994 / Net I/σ(I): 26.1
Reflection shellResolution: 2.54→2.63 Å / Num. unique obs: 5425 / CC1/2: 0.856

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Processing

Software
NameVersionClassification
REFMAC1.19.1_4122refinement
PHENIX1.19.1_4122refinement
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 7SQP

7sqp


Resolution: 2.54→48.84 Å / SU ML: 0.2673 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 24.8114
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.2423 2956 4.94 %
Rwork0.2167 56935 -
obs0.2179 59891 97.25 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 56.63 Å2
Refinement stepCycle: LAST / Resolution: 2.54→48.84 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms7457 0 10 159 7626
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00177652
X-RAY DIFFRACTIONf_angle_d0.505510424
X-RAY DIFFRACTIONf_chiral_restr0.03931118
X-RAY DIFFRACTIONf_plane_restr0.00431356
X-RAY DIFFRACTIONf_dihedral_angle_d4.79651078
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.54-2.580.30121330.28732301X-RAY DIFFRACTION84.81
2.58-2.630.31161240.26642539X-RAY DIFFRACTION92.18
2.63-2.670.33311530.28512538X-RAY DIFFRACTION93.11
2.67-2.720.29591240.27852600X-RAY DIFFRACTION94.52
2.72-2.780.28151290.25742578X-RAY DIFFRACTION94.29
2.78-2.840.26871350.25812616X-RAY DIFFRACTION95.36
2.84-2.910.28581390.26262643X-RAY DIFFRACTION96.13
2.91-2.980.34961350.25962663X-RAY DIFFRACTION96.45
2.98-3.060.27511630.26582674X-RAY DIFFRACTION98.2
3.06-3.150.26661460.24112725X-RAY DIFFRACTION98.46
3.15-3.250.26461390.23882740X-RAY DIFFRACTION99.31
3.25-3.370.28821410.22872783X-RAY DIFFRACTION99.86
3.37-3.50.25111310.22872774X-RAY DIFFRACTION99.93
3.5-3.660.22081650.21572754X-RAY DIFFRACTION99.86
3.66-3.860.21661440.20212768X-RAY DIFFRACTION99.83
3.86-4.10.20391350.18892803X-RAY DIFFRACTION99.86
4.1-4.410.18871560.17492805X-RAY DIFFRACTION100
4.41-4.860.18421430.16142819X-RAY DIFFRACTION100
4.86-5.560.19781420.18842863X-RAY DIFFRACTION99.97
5.56-70.28951490.22812885X-RAY DIFFRACTION99.97
7-48.840.25481300.22243064X-RAY DIFFRACTION99.44
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
12.059574942441.260180533750.491486620990.9792736832840.3506327073830.0203711058681-0.3102551736620.3210822530710.371411057833-0.08959079300120.1874586693360.149761970089-0.02493851873520.180263137823-0.002996301365220.333749110743-0.086082735164-0.06074290510740.4054281596810.06592416879410.319859707311-14.088326810131.2711693036-41.1190465459
22.80001137751.00736945090.423308256451.032200749570.5546978307560.92960588096-0.0143292676966-0.2280848690260.1474142886780.0376799793651-0.05692917088830.060840256740.192601064132-0.0293876923468-0.004157203792810.342229995542-0.0251558293023-0.02664273106470.334561819894-0.0006010849810950.331868128871-3.6337598842337.2854138869-24.1371994602
30.357005675474-0.582457997995-0.5403395082540.2589578167940.2478409453290.453851085531-0.759827052576-0.07012851405670.7817556848450.0742576198190.5813477220790.297365658892-0.8487904976250.547925244626-0.07207079509590.782525441353-0.346169669072-0.4426981486030.4743184061720.2609772798370.873551170046-11.863759072949.994922808-52.5586768485
4-0.01016060349950.0060488128263-0.002890745604090.000745760845728-0.0293234591020.04561070303780.1680144245410.0899621566074-0.2163093088530.4229247599060.000721331313465-0.03442775127480.129974460371-0.00965296332264-0.0006596429269890.4042036547450.0231315049936-0.06485194598730.5604799168930.02830639459170.421933924387-40.20617315915.6482176143-50.8874052126
50.3384774570290.1387237941380.04357260679260.1715946435820.1129170439940.231430960069-0.09048050975650.351208311168-0.644209860192-0.08758945174790.334231084033-0.03052008403640.1094724708160.3898297547980.03779032351620.320139280564-0.0137271000837-0.01410624220990.4328695898640.08351801151480.443277362945-38.836234735.94060357678-38.0002585623
60.412908346356-0.0488553591655-0.3223501471960.1078067241850.0461196477710.253981015467-0.0618726296736-0.0148399434552-0.1054442603770.01936509839090.120273239728-0.180173589658-0.260481959567-0.006264459325190.01524590165580.717867307112-0.206887551492-0.2118624695841.476587949250.005130877204030.796617052798-34.278426436115.4773926466-60.7346255004
70.1747308721230.0323660036612-0.01334118754490.4792631515970.1666505151140.227063763212-0.121441684463-0.01641473557030.1229779241540.1708247070280.48140374392-0.2138761439670.1999225907150.04293394403410.001002582165380.328713396403-0.049035744625-0.008854715066110.3731082692130.01092911792930.312444453544-30.518498360818.1818570663-41.2313931453
80.153425458323-0.1409183368320.06757982114170.153755673683-0.1370170786050.107792868308-0.01562061998930.132051001934-0.401110900873-0.07810830905750.195098742065-0.3794138385850.1284194957530.2544043397760.0006457753709990.387017122714-0.01448171313040.03184241191880.490944427684-0.0492882699490.4326313211-25.44637694378.74517387974-42.8045466506
90.1326681097020.04623611242660.04954118401710.04789030154980.082479213990.03817592988060.02084248916830.407388145936-0.704498368137-0.09385914237080.1997959711390.0209912493041-0.08408563382070.348034350518-0.0009182208968810.402071627771-0.0436101510702-0.06978106922020.553080492361-0.07933683732910.476374610717-33.21088090796.39143096314-49.380272717
100.0137724485603-0.0145985976469-0.0109951565037-0.004929412125590.007361321597980.026490839445-0.470691595364-0.2928103677840.01738402914150.2990649045360.26354892637-0.376405757865-0.418147264631-0.0331371006166-0.001580201613010.445850934467-0.006112596979320.04515007535510.4192250235850.009212819848930.406596289081-33.36807631628.45627891734-29.2635287725
110.02925065506840.00871114062463-0.0169042793160.030019164643-0.03668470398790.0426848330637-0.1747021549040.0836541897158-0.0465311750444-0.1818636480770.04807513407580.04832624412630.0270448459419-0.1130106318360.0001337665239590.363777077536-0.08945707639310.008775172991390.3767347185130.05153817162070.342652188845-34.374429691917.504272151-42.8556279923
120.4321320716260.1512018583230.337202437410.0356185540591-0.05878674758130.150483490372-0.1428527989360.1784778288370.147163775031-0.05432589474940.2655885520450.099545408092-0.04420777626190.0570428054063-1.90897561906E-50.43789930871-0.05407767838660.01254880867330.4822378967540.02855019779240.367959663859-34.745878543318.5204786953-45.6075117057
131.97992671976-0.646139084675-0.6854584672450.9500606600630.2415821168040.236203447379-0.187845880658-0.117055797342-0.2340215043430.03683669255780.06050605766590.1015888252060.01425430838150.159561076652-0.0001455464656990.2992628979030.0509818103270.03671860803180.3509067628140.03381486877560.329098435222-11.834347903287.1885287516-23.3932861685
142.49442862125-0.6464914755-0.388390672811.054493851040.2248264171940.714551364026-0.04542329651560.311214734351-0.210000961166-0.0816911077305-0.0573084382052-0.00526528747443-0.09541689869440.0149077316698-0.0006667922873690.3248579431210.02266453793430.02758281982350.327358498502-0.02582050147280.330253294113-2.3764975698479.8486364031-38.3814316955
150.3317661045780.06387602559310.4353207456870.279275691767-0.002419074372120.402810792102-0.05347545967910.142636630586-0.3955851784810.2616496958310.1785239924150.4783230306910.33832129996-0.1624975145290.0624628127660.5353185776670.07580078267990.2177735185250.4486998459690.186914077510.661307181447-10.954832131468.0650992356-11.4244488507
160.015452343568-0.02886539825550.03250715281910.0697903697552-0.06195207720160.114879639061-0.2503813867330.2367713469460.35336364199-0.01640412705760.4944082444250.163252357753-0.132831702669-0.0413025538162-0.0001630930409440.2809239677680.01319162744160.07567620814910.4727061013990.01931935193890.461547375028-37.973312531103.742929864-15.3495675691
170.0460340010774-0.0607289714945-0.03821073022170.02020826610450.01469987106680.0072998788847-0.1264395713640.5583448223660.520935582647-0.5835675434220.1639373270020.325103753428-0.0206274223007-0.1891338159320.0001205276231560.4031136512640.004322919651-0.01820386883870.4158242977830.02043283905470.375379300402-37.6485181082112.656769062-35.9705736893
180.0446249107461-0.01572732630640.00966486773393-0.000673421678274-0.01913346247010.0210623187932-0.100345330792-0.344975329171-0.067201455310.654660955636-0.1737722298160.06602033986930.09346698176530.3799333646140.006178773002770.3871949988070.09075514755520.01385388118020.4502096570350.007272051393420.457011173284-34.9990473395111.043530386-21.7889655685
190.01340005782770.00225656906480.01205564390440.01321746835720.001482383618480.01039533147890.02156648895550.170965772950.0300566170306-0.0784562221866-0.06135684684940.09458982925690.295821594013-0.1726665731860.0001205800678220.896409740360.1808055333840.1845332802711.49759717325-0.2698958306450.748059419622-31.8619922968105.181035592-5.4659692843
200.151243725079-0.06647662238660.05480455571530.06119992662240.02108888582480.01087638454030.02227830316390.05409908507540.1106454152160.02770052927170.131053934706-0.0769160513658-0.621045120123-0.172408759820.00020290621030.4258917456790.0837316948914-0.05306322796430.3259282407820.006908189476130.367327387212-28.7514965252102.345987315-21.0897097592
210.0720525458979-0.08920993206040.002966938091520.255349679843-0.1364221536110.0733490575338-0.1670703048070.368320808220.0772950083026-0.2503160562650.268425798109-0.222380952766-0.1736346696280.5148567707493.9899675786E-50.3487322195380.0145915702262-0.04419766213820.398218765876-0.01882782033270.369570240784-23.9220015607102.927867333-25.2023136171
220.03148862211430.0313148744850.002260820185530.0642193232151-0.06670856192770.33939613724-0.261539483557-0.09284829007270.8195431980110.2657238905110.296747267252-0.0412094582067-0.601883522045-0.429494796091-0.0049465427050.3562422865240.02842657625-0.0387427619950.4692471722290.04122625430470.403648746693-25.3794240616111.973256644-24.8758459403
230.03072650982530.0368169666586-0.06942042873750.008916308868720.0179985793890.09634274919360.213227563982-0.453227283403-0.28735198630.454808787911-0.0223225422114-0.0829336436343-0.08935608877560.08270770861010.0008058396754040.480130474493-0.02334482325420.02262692535260.4437148631780.04641075025140.409950446203-30.8881533578112.732693687-18.1891180955
240.0798321622239-0.00173726774551-0.00459538523220.0218565928556-0.012892380178-0.00180310152532-0.02719952226350.108566585842-0.00627398764974-0.3064375586030.314162664616-0.385961317639-0.2975789401230.360720548090.001413723689650.508967462317-0.0127730915492-0.02072723011340.4626636076020.02868232607390.402412845936-30.8797642744108.313170198-37.5722225463
250.0320697364201-0.0402657606080.02156929920080.0356797154363-0.01341214954940.00611016172939-0.1417601602020.09587459327250.08874441989940.0780943244354-0.1835546224940.3252139419380.0882843445312-0.3376938982410.0004792401458130.3269496514230.0366995082181-0.0020414915880.3037568511310.01819265375230.343595316599-32.1974559713100.91846216-23.082887733
260.01502164097630.03918307072-0.01766974184030.131231732472-0.04611336149750.100218426612-0.211561266202-0.379285347478-0.7952557775390.1372373681850.3767386808580.3607338651540.0793591402936-0.08076762263580.001241654184250.4071569309110.08897616516970.003980187716590.5269335471360.08572540158320.479108607968-30.105624374597.2949912921-13.7036178973
270.02629826153620.04857031963550.005046595673140.0365474339664-0.01119782741690.02561296365060.143911744446-0.173678588167-0.202464477092-0.520916922395-0.3075446562190.02589572371310.38808194358-0.363738099822-0.0003616832779850.3512999515370.00513271012321-0.03296706655860.491655830743-0.004999116172170.395368133396-38.6838676341105.858890292-34.2440030257
Refinement TLS group

Refine-ID: X-RAY DIFFRACTION

IDRefine TLS-IDSelection detailsAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
11chain 'A' and (resid 1 through 155 )AA1 - 1551 - 121
22chain 'A' and (resid 156 through 328 )AA156 - 328122 - 294
33chain 'A' and (resid 329 through 417 )AA329 - 417295 - 370
44chain 'B' and (resid 3 through 9 )BB3 - 91 - 7
55chain 'B' and (resid 10 through 26 )BB10 - 268 - 24
66chain 'B' and (resid 27 through 32 )BB27 - 3225 - 30
77chain 'B' and (resid 33 through 53 )BB33 - 5331 - 51
88chain 'B' and (resid 54 through 74 )BB54 - 7452 - 72
99chain 'B' and (resid 75 through 84 )BB75 - 8473 - 82
1010chain 'B' and (resid 85 through 92 )BB85 - 9283 - 90
1111chain 'B' and (resid 93 through 100 )BB93 - 10091 - 98
1212chain 'B' and (resid 101 through 117 )BB101 - 11799 - 115
1313chain 'C' and (resid 1 through 155 )CC1 - 1551 - 121
1414chain 'C' and (resid 156 through 340 )CC156 - 340122 - 306
1515chain 'C' and (resid 341 through 417 )CC341 - 417307 - 383
1616chain 'D' and (resid 3 through 9 )DD3 - 91 - 7
1717chain 'D' and (resid 10 through 19 )DD10 - 198 - 17
1818chain 'D' and (resid 20 through 26 )DD20 - 2618 - 24
1919chain 'D' and (resid 27 through 32 )DD27 - 3225 - 30
2020chain 'D' and (resid 33 through 41 )DD33 - 4131 - 39
2121chain 'D' and (resid 42 through 65 )DD42 - 6540 - 61
2222chain 'D' and (resid 66 through 74 )DD66 - 7462 - 70
2323chain 'D' and (resid 75 through 84 )DD75 - 8471 - 80
2424chain 'D' and (resid 85 through 92 )DD85 - 9281 - 88
2525chain 'D' and (resid 93 through 100 )DD93 - 10089 - 96
2626chain 'D' and (resid 101 through 111 )DD101 - 11197 - 107
2727chain 'D' and (resid 112 through 117 )DD112 - 117108 - 113

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