タイトル | Activation mechanism of caseinolytic chaperone-protease system in Mycobacterium tuberculosis by the anti-cancer drug bortezomib |
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ジャーナル・号・ページ | To Be Published |
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掲載日 | 2024年2月18日 (構造データの登録日) |
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著者 | Zhou B / Zhao H / Gao Y / Chen X / Zhang T / He J / Xiong X |
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リンク | PubMedで検索 |
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手法 | EM (単粒子) |
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解像度 | 2.15 - 3.69 Å |
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構造データ | EMDB-39157, PDB-8ycx: CryoEM structure of M. tuberculosis ClpC1P1P2 complex bound to bortezomib, conformation 2 手法: EM (単粒子) / 解像度: 2.2 Å EMDB-39161, PDB-8yd0: CryoEM structure of M. tuberculosis ClpXP1P2 complex bound to bortezomib 手法: EM (単粒子) / 解像度: 2.24 Å EMDB-39162, PDB-8yd1: CryoEM structure of M. tuberculosis ClpC1P1P2 complex bound to bortezomib, conformation 1 手法: EM (単粒子) / 解像度: 2.81 Å EMDB-39163, PDB-8yd2: CryoEM structure of M. tuberculosis ClpP1P2 bound to bortezomib 手法: EM (単粒子) / 解像度: 2.39 Å EMDB-39164, PDB-8yd4: CryoEM structure of apo M. tuberculosis ClpP1P2 手法: EM (単粒子) / 解像度: 3.69 Å EMDB-61842, PDB-9jvp: CryoEM structure of M. tuberculosis ClpC1P1P2 complex bound to bortezomib, conformation 3 手法: EM (単粒子) / 解像度: 2.15 Å EMDB-61847, PDB-9jvz: CryoEM structure of M. tuberculosis ClpP1P2 bound to bortezomib 手法: EM (単粒子) / 解像度: 2.56 Å |
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化合物 | ChemComp-BO2: N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE / ボルテゾミブ / 薬剤, 抗がん剤*YM
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由来 |  Mycobacterium tuberculosis (結核菌) mycobacterium tuberculosis h37rv (結核菌) bos grunniens (ヤク)
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キーワード | HYDROLASE / Mycobacterium tuberculosis / Caseinolytic protease system / Activation / holoenzymes / antibiotics / Bortezomib |
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