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6KA6
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CRYSTAL STRUCTURE OF PLASMODIUM LYSYL-TRNA SYNTHETASE IN COMPLEX WITH A CLADOSPORIN DERIVATIVE 1
Descriptor:Lysine--tRNA ligase, (3~{S})-3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, GLYCEROL, ...
Authors:Zhou, J., Fang, P.
Deposit date:2019-06-21
Release date:2020-04-08
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (1.891 Å)
Cite:Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.
Acs Chem.Biol., 15, 2020
6KAB
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CRYSTAL STRUCTURE OF PLASMODIUM LYSYL-TRNA SYNTHETASE IN COMPLEX WITH A CLADOSPORIN DERIVATIVE 2
Descriptor:Lysine--tRNA ligase, (3~{S})-3-(cyclohexylmethyl)-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, LYSINE
Authors:Zhou, J., Fang, P.
Deposit date:2019-06-21
Release date:2020-04-08
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (2.892 Å)
Cite:Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.
Acs Chem.Biol., 15, 2020
6KBF
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CRYSTAL STRUCTURE OF PLASMODIUM LYSYL-TRNA SYNTHETASE IN COMPLEX WITH A CLADOSPORIN DERIVATIVE 3
Descriptor:Lysine--tRNA ligase, LYSINE, (3~{S})-3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)-3,4-dihydro-2~{H}-isoquinolin-1-one, ...
Authors:Zhou, J., Fang, P.
Deposit date:2019-06-24
Release date:2020-04-08
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.
Acs Chem.Biol., 15, 2020
6KCN
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CRYSTAL STRUCTURE OF PLASMODIUM LYSYL-TRNA SYNTHETASE IN COMPLEX WITH A CLADOSPORIN DERIVATIVE 4
Descriptor:Lysine--tRNA ligase, 3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)isochromen-1-one, GLYCEROL, ...
Authors:Zhou, J., Fang, P.
Deposit date:2019-06-28
Release date:2020-04-08
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.
Acs Chem.Biol., 15, 2020
6KCT
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CRYSTAL STRUCTURE OF PLASMODIUM LYSYL-TRNA SYNTHETASE IN COMPLEX WITH A CLADOSPORIN DERIVATIVE 5
Descriptor:Lysine--tRNA ligase, 3-(cyclohexylmethyl)-6,8-bis(oxidanyl)isochromen-1-one, LYSINE
Authors:Zhou, J., Fang, P.
Deposit date:2019-06-29
Release date:2020-04-08
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase.
Acs Chem.Biol., 15, 2020
1OZB
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CRYSTAL STRUCTURE OF SECB COMPLEXED WITH SECA C-TERMINUS
Descriptor:Protein-export protein secB, Preprotein translocase secA subunit, ZINC ION
Authors:Zhou, J., Xu, Z.
Deposit date:2003-04-08
Release date:2003-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural determinants of SecB recognition by SecA in bacterial protein translocation
NAT.STRUCT.BIOL., 10, 2003
2IHX
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SOLUTION STRUCTURE OF THE ROUS SARCOMA VIRUS NUCLEOCAPSID PROTEIN:UPSI RNA PACKAGING SIGNAL COMPLEX
Descriptor:uPsi RNA, Nucleocapsid (NC) Protein, ZINC ION
Authors:Zhou, J., Summers, M.
Deposit date:2006-09-27
Release date:2007-01-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the Rous Sarcoma Virus Nucleocapsid Protein: muPsi RNA Packaging Signal Complex.
J.Mol.Biol., 365, 2007
3LWO
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STRUCTURE OF H/ACA RNP BOUND TO A SUBSTRATE RNA CONTAINING 5BRU
Descriptor:Pseudouridine synthase Cbf5, Ribosome biogenesis protein Nop10, 50S ribosomal protein L7Ae, ...
Authors:Zhou, J., Liang, B., Lv, C., Yang, W., Li, H.
Deposit date:2010-02-24
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.855 Å)
Cite:Glycosidic bond conformation preference plays a pivotal role in catalysis of RNA pseudouridylation: a combined simulation and structural study.
J.Mol.Biol., 401, 2010
3LWP
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STRUCTURE OF H/ACA RNP BOUND TO A SUBSTRATE RNA CONTAINING 5BRDU
Descriptor:Pseudouridine synthase Cbf5, Ribosome biogenesis protein Nop10, 50S ribosomal protein L7Ae, ...
Authors:Zhou, J., Liang, B., Lv, C., Yang, W., Li, H.
Deposit date:2010-02-24
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Glycosidic bond conformation preference plays a pivotal role in catalysis of RNA pseudouridylation: a combined simulation and structural study.
J.Mol.Biol., 401, 2010
3LWQ
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STRUCTURE OF H/ACA RNP BOUND TO A SUBSTRATE RNA CONTAINING 3MU
Descriptor:Pseudouridine synthase Cbf5, Ribosome biogenesis protein Nop10, 50S ribosomal protein L7Ae, ...
Authors:Zhou, J., Liang, B., Lv, C., Yang, W., Li, H.
Deposit date:2010-02-24
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.678 Å)
Cite:Functional and Structural Impact of Target Uridine Substitutions on the H/ACA Ribonucleoprotein Particle Pseudouridine Synthase .
Biochemistry, 49, 2010
3LWR
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STRUCTURE OF H/ACA RNP BOUND TO A SUBSTRATE RNA CONTAINING 4SU
Descriptor:Pseudouridine synthase Cbf5, Ribosome biogenesis protein Nop10, 50S ribosomal protein L7Ae, ...
Authors:Zhou, J., Liang, B., Lv, C., Yang, W., Li, H.
Deposit date:2010-02-24
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:Functional and Structural Impact of Target Uridine Substitutions on the H/ACA Ribonucleoprotein Particle Pseudouridine Synthase .
Biochemistry, 49, 2010
3LWV
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STRUCTURE OF H/ACA RNP BOUND TO A SUBSTRATE RNA CONTAINING 2'-DEOXYURIDINE
Descriptor:Pseudouridine synthase Cbf5, Ribosome biogenesis protein Nop10, 50S ribosomal protein L7Ae, ...
Authors:Zhou, J., Liang, B., Lv, C., Yang, W., Li, H.
Deposit date:2010-02-24
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.499 Å)
Cite:Functional and Structural Impact of Target Uridine Substitutions on the H/ACA Ribonucleoprotein Particle Pseudouridine Synthase .
Biochemistry, 49, 2010
3MQK
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CBF5-NOP10-GAR1 COMPLEX BINDING WITH 17MER RNA CONTAINING ACA TRINUCLEOTIDE
Descriptor:tRNA pseudouridine synthase B, Ribosome biogenesis protein Nop10, Small nucleolar rnp gar1-like protein, ...
Authors:Zhou, J., Liang, B., Li, H.
Deposit date:2010-04-28
Release date:2010-12-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and functional evidence of high specificity of Cbf5 for ACA trinucleotide.
Rna, 17, 2011
4V85
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CRYSTAL STRUCTURE OF RELEASE FACTOR RF3 TRAPPED IN THE GTP STATE ON A ROTATED CONFORMATION OF THE RIBOSOME.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Zhou, J., Lancaster, L., Trakhanov, S., Noller, H.F.
Deposit date:2011-06-13
Release date:2014-07-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of release factor RF3 trapped in the GTP state on a rotated conformation of the ribosome.
Rna, 18, 2012
4V89
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CRYSTAL STRUCTURE OF RELEASE FACTOR RF3 TRAPPED IN THE GTP STATE ON A ROTATED CONFORMATION OF THE RIBOSOME (WITHOUT VIOMYCIN)
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Zhou, J., Lancaster, L., Trakhanov, S., Noller, H.F.
Deposit date:2011-11-17
Release date:2014-07-09
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Crystal structure of release factor RF3 trapped in the GTP state on a rotated conformation of the ribosome.
Rna, 18, 2012
4V9J
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70S RIBOSOME TRANSLOCATION INTERMEDIATE GDPNP-II CONTAINING ELONGATION FACTOR EFG/GDPNP, MRNA, AND TRNA BOUND IN THE PE*/E STATE.
Descriptor:30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhou, J., Lancaster, L., Donohue, J.P., Noller, H.F.
Deposit date:2013-04-23
Release date:2014-07-09
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (3.86 Å)
Cite:Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation.
Science, 340, 2013
4V9K
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70S RIBOSOME TRANSLOCATION INTERMEDIATE GDPNP-I CONTAINING ELONGATION FACTOR EFG/GDPNP, MRNA, AND TRNA BOUND IN THE PE*/E STATE.
Descriptor:30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhou, J., Lancaster, L., Donohue, J.P., Noller, H.F.
Deposit date:2013-04-24
Release date:2014-07-09
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation.
Science, 340, 2013
4V9L
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70S RIBOSOME TRANSLOCATION INTERMEDIATE FA-3.6A CONTAINING ELONGATION FACTOR EFG/FUSIDIC ACID/GDP, MRNA, AND TRNA BOUND IN THE PE*/E STATE.
Descriptor:30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhou, J., Lancaster, L., Donohue, J.P., Noller, H.F.
Deposit date:2013-04-24
Release date:2014-07-09
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation.
Science, 340, 2013
4V9M
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70S RIBOSOME TRANSLOCATION INTERMEDIATE FA-4.2A CONTAINING ELONGATION FACTOR EFG/FUSIDIC ACID/GDP, MRNA, AND TRNA BOUND IN THE PE*/E STATE.
Descriptor:30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhou, J., Lancaster, L., Donohue, J.P., Noller, H.F.
Deposit date:2013-04-25
Release date:2014-07-09
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation.
Science, 340, 2013
4W29
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70S RIBOSOME TRANSLOCATION INTERMEDIATE CONTAINING ELONGATION FACTOR EFG/GDP/FUSIDIC ACID, MRNA, AND TRNAS TRAPPED IN THE AP/AP PE/E CHIMERIC HYBRID STATE.
Descriptor:30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhou, J., Lancaster, L., Donohue, J.P., Noller, H.F.
Deposit date:2014-07-02
Release date:2014-10-01
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:How the ribosome hands the A-site tRNA to the P site during EF-G-catalyzed translocation.
Science, 345, 2014
5CZW
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CRYSTAL STRUCTURE OF MYROILYSIN
Descriptor:Myroilysin, ZINC ION
Authors:Zhou, J., Ran, T., Xu, D., Wang, W.
Deposit date:2015-08-01
Release date:2016-08-03
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Myroilysin is a New Bacterial Member of the M12A Family of Metzincin Metallopeptidases and Activated by a Cysteine-switch Mechanism
J. Biol. Chem., 292, 2017
5ZE4
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THE STRUCTURE OF HOLO- STRUCTURE OF DHAD COMPLEX WITH [2FE-2S] CLUSTER
Descriptor:Dihydroxy-acid dehydratase, chloroplastic, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Zhou, J., Zang, X., Tang, Y., Yan, Y., Gan, J., Wu, L.
Deposit date:2018-02-26
Release date:2018-07-18
Last modified:2018-08-01
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action.
Nature, 559, 2018
2HZ6
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THE CRYSTAL STRUCTURE OF HUMAN IRE1-ALPHA LUMINAL DOMAIN
Descriptor:Endoplasmic reticulum to nucleus signalling 1 isoform 1 variant
Authors:Kaufman, R.J., Xu, Z., Zhou, J.
Deposit date:2006-08-08
Release date:2006-08-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response.
Proc.Natl.Acad.Sci.Usa, 103, 2006
6M10
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CRYSTAL STRUCTURE OF PA4853 (FIS) FROM PSEUDOMONAS AERUGINOSA
Descriptor:Putative Fis-like DNA-binding protein
Authors:Zhang, H., Gao, Z., Zhou, J., Dong, Y.
Deposit date:2020-02-24
Release date:2020-05-13
Method:X-RAY DIFFRACTION (2.985 Å)
Cite:Crystal structure of the nucleoid-associated protein Fis (PA4853) from Pseudomonas aeruginosa.
Acta Crystallogr.,Sect.F, 76, 2020
6N1D
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X-RAY CRYSTAL COMPLEX SHOWING SPONTANEOUS RIBOSOMAL TRANSLOCATION OF MRNA AND TRNAS INTO A CHIMERIC HYBRID STATE
Descriptor:16S rRNA, 23S rRNA, 5s rRNA, ...
Authors:Noller, H.F., Donohue, J.P., Lancaster, L., Zhou, J.
Deposit date:2018-11-08
Release date:2019-04-03
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Spontaneous ribosomal translocation of mRNA and tRNAs into a chimeric hybrid state.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019