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1A0G
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L201A MUTANT OF D-AMINO ACID AMINOTRANSFERASE COMPLEXED WITH PYRIDOXAMINE-5'-PHOSPHATE
Descriptor:D-AMINO ACID AMINOTRANSFERASE, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE
Authors:Sugio, S., Kashima, A., Kishimoto, K., Peisach, D., Petsko, G.A., Ringe, D., Yoshimura, T., Esaki, N.
Deposit date:1997-11-30
Release date:1998-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of L201A mutant of D-amino acid aminotransferase at 2.0 A resolution: implication of the structural role of Leu201 in transamination.
Protein Eng., 11, 1998
2DAB
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L201A MUTANT OF D-AMINO ACID AMINOTRANSFERASE COMPLEXED WITH PYRIDOXAL-5'-PHOSPHATE
Descriptor:D-AMINO ACID AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Sugio, S., Kashima, A., Kishimoto, K., Peisach, D., Petsko, G.A., Ringe, D., Yoshimura, T., Esaki, N.
Deposit date:1997-11-30
Release date:1998-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of L201A mutant of D-amino acid aminotransferase at 2.0 A resolution: implication of the structural role of Leu201 in transamination.
Protein Eng., 11, 1998
2ZRU
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CRYSTAL STRUCTURE OF SULFOLOBUS SHIBATAE ISOPENTENYL DIPHOSPHATE ISOMERASE IN COMPLEX WITH FMN
Descriptor:Isopentenyl-diphosphate delta-isomerase, FLAVIN MONONUCLEOTIDE
Authors:Unno, H., Yamashita, S., Ikeda, Y., Sekiguchi, S., Yoshida, N., Yoshimura, T., Kusunoki, M., Nakayama, T., Nishino, T., Hemmi, H.
Deposit date:2008-09-01
Release date:2009-01-20
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:New role of flavin as a general acid-base catalyst with no redox function in type 2 isopentenyl-diphosphate isomerase.
J.Biol.Chem., 284, 2009
2ZRV
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CRYSTAL STRUCTURE OF SULFOLOBUS SHIBATAE ISOPENTENYL DIPHOSPHATE ISOMERASE IN COMPLEX WITH REDUCED FMN.
Descriptor:Isopentenyl-diphosphate delta-isomerase, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL
Authors:Unno, H., Yamashita, S., Ikeda, Y., Sekiguchi, S., Yoshida, N., Yoshimura, T., Kusunoki, M., Nakayama, T., Nishino, T., Hemmi, H.
Deposit date:2008-09-01
Release date:2009-01-20
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:New role of flavin as a general acid-base catalyst with no redox function in type 2 isopentenyl-diphosphate isomerase.
J.Biol.Chem., 284, 2009
2ZRW
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CRYSTAL STRUCTURE OF SULFOLOBUS SHIBATAE ISOPENTENYL DIPHOSPHATE ISOMERASE IN COMPLEX WITH FMN AND IPP.
Descriptor:Isopentenyl-diphosphate delta-isomerase, FLAVIN MONONUCLEOTIDE, ISOPENTYL PYROPHOSPHATE, ...
Authors:Unno, H., Yamashita, S., Ikeda, Y., Sekiguchi, S., Yoshida, N., Yoshimura, T., Kusunoki, M., Nakayama, T., Nishino, T., Hemmi, H.
Deposit date:2008-09-01
Release date:2009-01-20
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:New role of flavin as a general acid-base catalyst with no redox function in type 2 isopentenyl-diphosphate isomerase.
J.Biol.Chem., 284, 2009
2ZRX
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CRYSTAL STRUCTURE OF SULFOLOBUS SHIBATAE ISOPENTENYL DIPHOSPHATE ISOMERASE IN COMPLEX WITH FMN AND DMAPP.
Descriptor:Isopentenyl-diphosphate delta-isomerase, FLAVIN MONONUCLEOTIDE, DIMETHYLALLYL DIPHOSPHATE, ...
Authors:Unno, H., Yamashita, S., Ikeda, Y., Sekiguchi, S., Yoshida, N., Yoshimura, T., Kusunoki, M., Nakayama, T., Nishino, T., Hemmi, H.
Deposit date:2008-09-01
Release date:2009-01-20
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:New role of flavin as a general acid-base catalyst with no redox function in type 2 isopentenyl-diphosphate isomerase.
J.Biol.Chem., 284, 2009
2ZRY
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CRYSTAL STRUCTURE OF SULFOLOBUS SHIBATAE ISOPENTENYL DIPHOSPHATE ISOMERASE IN COMPLEX WITH REDUCED FMN AND IPP.
Descriptor:Isopentenyl-diphosphate delta-isomerase, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Unno, H., Yamashita, S., Ikeda, Y., Sekiguchi, S., Yoshida, N., Yoshimura, T., Kusunoki, M., Nakayama, T., Nishino, T., Hemmi, H.
Deposit date:2008-09-01
Release date:2009-01-20
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:New role of flavin as a general acid-base catalyst with no redox function in type 2 isopentenyl-diphosphate isomerase.
J.Biol.Chem., 284, 2009
2ZRZ
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CRYSTAL STRUCTURE OF SULFOLOBUS SHIBATAE ISOPENTENYL DIPHOSPHATE ISOMERASE IN COMPLEX WITH REDUCED FMN AND DMAPP
Descriptor:Isopentenyl-diphosphate delta-isomerase, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, DIMETHYLALLYL DIPHOSPHATE, ...
Authors:Unno, H., Yamashita, S., Ikeda, Y., Sekiguchi, S., Yoshida, N., Yoshimura, T., Kusunoki, M., Nakayama, T., Nishino, T., Hemmi, H.
Deposit date:2008-09-01
Release date:2009-01-20
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:New role of flavin as a general acid-base catalyst with no redox function in type 2 isopentenyl-diphosphate isomerase.
J.Biol.Chem., 284, 2009
1ET0
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CRYSTAL STRUCTURE OF AMINODEOXYCHORISMATE LYASE FROM ESCHERICHIA COLI
Descriptor:4-AMINO-4-DEOXYCHORISMATE LYASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Nakai, T., Mizutani, H., Miyahara, I., Hirotsu, K., Takeda, S., Jhee, K.H., Yoshimura, T., Esaki, N.
Deposit date:2000-04-12
Release date:2000-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional structure of 4-amino-4-deoxychorismate lyase from Escherichia coli.
J.Biochem.(Tokyo), 128, 2000
3VKJ
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CRYSTAL STRUCTURE OF SULFOLOBUS SHIBATAE ISOPENTENYL DIPHOSPHATE ISOMERASE, OCTAMERIC FORM
Descriptor:Isopentenyl-diphosphate delta-isomerase, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL
Authors:Nakatani, H., Goda, S., Unno, H., Nagai, T., Yoshimura, T., Hemmi, H.
Deposit date:2011-11-17
Release date:2012-05-30
Last modified:2012-07-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Substrate-Induced Change in the Quaternary Structure of Type 2 Isopentenyl Diphosphate Isomerase from Sulfolobus shibatae.
J.Bacteriol., 194, 2012
4TV7
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CRYSTAL STRUCTURE OF BACILLUS SUBTILIS GABR AT 2.05 ANGSTROMS RESOLUTION
Descriptor:HTH-type transcriptional regulatory protein GabR
Authors:Goto, M., Okuda, K., Yoshimura, T.
Deposit date:2014-06-26
Release date:2014-12-24
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Role of the aminotransferase domain in Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator
Mol. Microbiol., 95, 2015
1L6F
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ALANINE RACEMASE BOUND WITH N-(5'-PHOSPHOPYRIDOXYL)-L-ALANINE
Descriptor:alanine racemase, ALANYL-PYRIDOXAL-5'-PHOSPHATE
Authors:Watanabe, A., Yoshimura, T., Mikami, B., Hayashi, H., Kagamiyama, H., Esaki, N.
Deposit date:2002-03-09
Release date:2002-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Reaction mechanism of alanine racemase from Bacillus stearothermophilus: x-ray crystallographic studies of the enzyme bound with N-(5'-phosphopyridoxyl)alanine.
J.Biol.Chem., 277, 2002
1L6G
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ALANINE RACEMASE BOUND WITH N-(5'-PHOSPHOPYRIDOXYL)-D-ALANINE
Descriptor:alanine racemase, N-(5'-PHOSPHOPYRIDOXYL)-D-ALANINE
Authors:Watanabe, A., Yoshimura, T., Mikami, B., Hayashi, H., Kagamiyama, H., Esaki, N.
Deposit date:2002-03-10
Release date:2002-06-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Reaction mechanism of alanine racemase from Bacillus stearothermophilus: x-ray crystallographic studies of the enzyme bound with N-(5'-phosphopyridoxyl)alanine.
J.Biol.Chem., 277, 2002
3ATQ
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GERANYLGERANYL REDUCTASE (GGR) FROM SULFOLOBUS ACIDOCALDARIUS
Descriptor:Conserved Archaeal protein, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, TETRADECANE
Authors:Sasaki, D., Fujihashi, M., Murakami, M., Yoshimura, T., Hemmi, H., Miki, K.
Deposit date:2011-01-12
Release date:2011-05-04
Last modified:2013-12-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure and mutation analysis of archaeal geranylgeranyl reductase
J.Mol.Biol., 409, 2011
3ATR
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GERANYLGERANYL REDUCTASE (GGR) FROM SULFOLOBUS ACIDOCALDARIUS CO-CRYSTALLIZED WITH ITS LIGAND
Descriptor:Conserved Archaeal protein, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, nonane, ...
Authors:Fujihashi, M., Sasaki, D., Iwata, Y., Yoshimura, T., Hemmi, H., Miki, K.
Deposit date:2011-01-12
Release date:2011-05-04
Last modified:2013-12-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and mutation analysis of archaeal geranylgeranyl reductase
J.Mol.Biol., 409, 2011
2ZPU
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CRYSTAL STRUCTURE OF MODIFIED SERINE RACEMASE FROM S.POMBE.
Descriptor:Uncharacterized protein C320.14, MAGNESIUM ION, N-(5'-PHOSPHOPYRIDOXYL)-D-ALANINE
Authors:Goto, M.
Deposit date:2008-07-29
Release date:2009-04-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Serine racemase with catalytically active lysinoalanyl residue.
J.Biochem., 145, 2009
1WTC
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CRYSTAL STRUCTURE OF S.POMBE SERINE RACEMASE COMPLEX WITH AMPPCP
Descriptor:Hypothetical protein C320.14 in chromosome III, MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Goto, M., Miyahara, I., Hirotsu, K.
Deposit date:2004-11-22
Release date:2005-11-01
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a homolog of mammalian serine racemase from Schizosaccharomyces pombe
J.Biol.Chem., 284, 2009
2ZR8
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CRYSTAL STRUCTURE OF MODIFIED SERINE RACEMASE COMPLEXED WITH SERINE
Descriptor:Uncharacterized protein C320.14, N-(5'-PHOSPHOPYRIDOXYL)-D-ALANINE, SERINE, ...
Authors:Goto, M.
Deposit date:2008-08-25
Release date:2009-07-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of a homolog of mammalian serine racemase from Schizosaccharomyces pombe
J.Biol.Chem., 284, 2009
3B03
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CRYSTAL STRUCTURE OF SULFOLOBUS SHIBATAE ISOPENTENYL DIPHOSPHATE ISOMERASE IN COMPLEX WITH VIPP.
Descriptor:Isopentenyl-diphosphate delta-isomerase, 1-deoxy-1-[(4aR)-4a-[(2Z)-2-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)but-2-en-1-yl]-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-5-O-phosphono-D-ribitol, MAGNESIUM ION
Authors:Unno, H., Nagai, T., Hemmi, H.
Deposit date:2011-06-03
Release date:2011-11-02
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Covalent modification of reduced flavin mononucleotide in type-2 isopentenyl diphosphate isomerase by active-site-directed inhibitors.
Proc.Natl.Acad.Sci.USA, 108, 2011
3B04
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CRYSTAL STRUCTURE OF SULFOLOBUS SHIBATAE ISOPENTENYL DIPHOSPHATE ISOMERASE IN COMPLEX WITH OIPP.
Descriptor:Isopentenyl-diphosphate delta-isomerase, 1-deoxy-1-[(4aR)-4a-[(2R)-1-hydroxy-5-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}-3-methylidenepentan-2-yl]-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-5-O-phosphono-D-ribitol, MAGNESIUM ION
Authors:Unno, H., Nagai, T., Hemmi, H.
Deposit date:2011-06-03
Release date:2011-11-02
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Covalent modification of reduced flavin mononucleotide in type-2 isopentenyl diphosphate isomerase by active-site-directed inhibitors.
Proc.Natl.Acad.Sci.USA, 108, 2011
3B05
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CRYSTAL STRUCTURE OF SULFOLOBUS SHIBATAE ISOPENTENYL DIPHOSPHATE ISOMERASE IN COMPLEX WITH REDUCED FMN AND IPP AT 2.2A RESOLUTION.
Descriptor:Isopentenyl-diphosphate delta-isomerase, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Unno, H., Nagai, T., Hemmi, H.
Deposit date:2011-06-03
Release date:2011-11-02
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Covalent modification of reduced flavin mononucleotide in type-2 isopentenyl diphosphate isomerase by active-site-directed inhibitors.
Proc.Natl.Acad.Sci.USA, 108, 2011
3B06
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CRYSTAL STRUCTURE OF SULFOLOBUS SHIBATAE ISOPENTENYL DIPHOSPHATE ISOMERASE IN COMPLEX WITH REDUCED FMN AND DMAPP.
Descriptor:Isopentenyl-diphosphate delta-isomerase, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, DIMETHYLALLYL DIPHOSPHATE, ...
Authors:Unno, H., Nagai, T., Hemmi, H.
Deposit date:2011-06-03
Release date:2011-11-02
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Covalent modification of reduced flavin mononucleotide in type-2 isopentenyl diphosphate isomerase by active-site-directed inhibitors.
Proc.Natl.Acad.Sci.USA, 108, 2011
5GMD
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CRYSTAL STRUCTURE OF SULFOLOBUS SOLFATARICUS DIPHOSPHOMEVALONATE DECARBOXYLASE IN COMPLEX WITH ATP-GAMMA-S
Descriptor:Diphosphomevalonate decarboxylase, (3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC ACID, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Unno, H., Hemmi, H., Hattori, A.
Deposit date:2016-07-13
Release date:2016-12-28
Last modified:2017-02-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A Single Amino Acid Mutation Converts (R)-5-Diphosphomevalonate Decarboxylase into a Kinase
J. Biol. Chem., 292, 2017
5GME
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CRYSTAL STRUCTURE OF SULFOLOBUS SOLFATARICUS DIPHOSPHOMEVALONATE DECARBOXYLASE IN COMPLEX WITH ADP
Descriptor:Diphosphomevalonate decarboxylase, (3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Unno, H., Hemmi, H., Hattori, A.
Deposit date:2016-07-13
Release date:2016-12-28
Last modified:2017-02-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A Single Amino Acid Mutation Converts (R)-5-Diphosphomevalonate Decarboxylase into a Kinase
J. Biol. Chem., 292, 2017
4Z7C
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DIPHOSPHOMEVALONATE DECARBOXYLASE FROM THE SULFOLOBUS SOLFATARICUS, SPACE GROUP H32
Descriptor:Diphosphomevalonate decarboxylase, PHOSPHATE ION, SODIUM ION, ...
Authors:Unno, H., Hattori, A., Hemmi, H.
Deposit date:2015-04-07
Release date:2015-09-16
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:In Vivo Formation of the Protein Disulfide Bond That Enhances the Thermostability of Diphosphomevalonate Decarboxylase, an Intracellular Enzyme from the Hyperthermophilic Archaeon Sulfolobus solfataricus
J.Bacteriol., 197, 2015
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