Author results

1UJ1
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO)
Descriptor:3C-like proteinase
Authors:Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z.
Deposit date:2003-07-25
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
1UK2
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO) AT PH8.0
Descriptor:3C-LIKE PROTEINASE
Authors:Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z.
Deposit date:2003-08-14
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
1UK3
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO) AT PH7.6
Descriptor:3C-like proteinase
Authors:Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z.
Deposit date:2003-08-14
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
1UK4
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CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO) COMPLEXED WITH AN INHIBITOR
Descriptor:3C-like proteinase, 5-mer peptide of inhibitor, CHLOROACETONE
Authors:Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z.
Deposit date:2003-08-14
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
1WOF
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CRYSTAL STRUCTURE OF SARS-COV MPRO IN COMPLEX WITH AN INHIBITOR N1
Descriptor:3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]-L-ALANYL-L-VALYL-N~1~-((1S)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
Authors:Yang, H., Bartlam, M., Xue, X., Yang, K., Liang, W., Rao, Z.
Deposit date:2004-08-18
Release date:2005-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
2AMD
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CRYSTAL STRUCTURE OF SARS_COV MPRO IN COMPLEX WITH AN INHIBITOR N9
Descriptor:3C-like proteinase, N-(3-FUROYL)-D-VALYL-L-VALYL-N~1~-((1R,2Z)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-D-LEUCINAMIDE
Authors:Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z.
Deposit date:2005-08-09
Release date:2005-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
2AMP
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CRYSTAL STRUCTURE OF PORCINE TRANSMISSIBLE GASTROENTERITIS VIRUS MPRO IN COMPLEX WITH AN INHIBITOR N1
Descriptor:3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]-L-ALANYL-L-VALYL-N~1~-((1S)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
Authors:Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z.
Deposit date:2005-08-10
Release date:2005-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
2AMQ
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CRYSTAL STRUCTURE OF SARS_COV MPRO IN COMPLEX WITH AN INHIBITOR N3
Descriptor:3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
Authors:Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z.
Deposit date:2005-08-10
Release date:2005-09-13
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
2D2D
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CRYSTAL STRUCTURE OF SARS-COV MPRO IN COMPLEX WITH AN INHIBITOR I2
Descriptor:3C-like proteinase, ETHYL (2E,4S)-4-[((2R)-2-{[N-(TERT-BUTOXYCARBONYL)-L-VALYL]AMINO}-2-PHENYLETHANOYL)AMINO]-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENT-2-ENOATE
Authors:Yang, H., Bartlam, M., Xue, X., Yang, K., Liang, W., Ding, Y., Rao, Z.
Deposit date:2005-09-08
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
5GXJ
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ZIKA VIRUS NS2B-NS3 PROTEASE
Descriptor:FLAVIVIRUS_NS2B,LINKER,Peptidase S7
Authors:Yang, H., Chen, X., Ji, X., Xiong, Y., Yang, K.
Deposit date:2016-09-18
Release date:2017-05-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Viral protease activation mechanism
To Be Published
3NK6
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STRUCTURE OF THE NOSIHEPTIDE-RESISTANCE METHYLTRANSFERASE
Descriptor:23S rRNA methyltransferase
Authors:Yang, H., Wang, Z., Shen, Y., Wang, P., Murchie, A., Xu, Y.
Deposit date:2010-06-18
Release date:2010-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Nosiheptide-Resistance Methyltransferase of Streptomyces actuosus
Biochemistry, 49, 2010
3NK7
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STRUCTURE OF THE NOSIHEPTIDE-RESISTANCE METHYLTRANSFERASE S-ADENOSYL-L-METHIONINE COMPLEX
Descriptor:23S rRNA methyltransferase, S-ADENOSYLMETHIONINE
Authors:Yang, H., Wang, Z., Shen, Y., Wang, P., Murchie, A., Xu, Y.
Deposit date:2010-06-18
Release date:2010-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the Nosiheptide-Resistance Methyltransferase of Streptomyces actuosus
Biochemistry, 49, 2010
1XMA
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STRUCTURE OF A TRANSCRIPTIONAL REGULATOR FROM CLOSTRIDIUM THERMOCELLUM CTH-833
Descriptor:Predicted transcriptional regulator, MERCURY (II) ION, UNKNOWN ATOM OR ION
Authors:Yang, H., Chen, L., Lee, D., Habel, J., Nguyen, J., Chang, S.-H., Kataeva, I., Xu, H., Chang, J., Zhao, M., Horanyi, P., Florence, Q., Zhou, W., Tempel, W., Lin, D., Praissman, J., Zhang, H., Arendall III, W.B., Richardson, J.S., Richardson, D.C., Ljungdahl, L., Liu, Z.-J., Rose, J.P., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2004-10-01
Release date:2004-12-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structure of a transcriptional regulator from Clostridium thermocellum Cth-833
To be published
1ZGH
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METHIONYL-TRNA FORMYLTRANSFERASE FROM CLOSTRIDIUM THERMOCELLUM
Descriptor:Methionyl-tRNA formyltransferase, UNKNOWN ATOM OR ION
Authors:Yang, H., Kataeva, I., Xu, H., Zhao, M., Chang, J., Liu, Z., Chen, L., Tempel, W., Habel, J., Zhou, W., Lee, D., Lin, D., Chang, S., Arendall III, W.B., Richardson, J.S., Richardson, D.C., Rose, J.P., Wang, B., Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2005-04-21
Release date:2005-05-03
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Methionyl-tRNA formyltransferase from Clostridium thermocellum
To be published
3NFP
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THERAPEUTIC ANTIBODY DACLIZUMAB IN COMPLEX WITH IL-2RA (CD25) ECTODOMAIN
Descriptor:Heavy chain of Fab fragment of daclizumab, Light chain of Fab fragment of daclizumab, Interleukin-2 receptor subunit alpha
Authors:Yang, H., Wang, J., Du, J., Zhong, C., Guo, Y., Ding, J.
Deposit date:2010-06-10
Release date:2010-09-15
Last modified:2013-10-16
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Structural basis of immunosuppression by the therapeutic antibody daclizumab
Cell Res., 20, 2010
3NFS
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CRYSTAL STRUCTURE THE FAB FRAGMENT OF THERAPEUTIC ANTIBODY DACLIZUMAB
Descriptor:Heavy chain of Fab fragment of daclizumab, Light chain of Fab fragment of daclizumab
Authors:Yang, H., Wang, J., Du, J., Zhong, C., Guo, Y., Ding, J.
Deposit date:2010-06-10
Release date:2010-09-15
Last modified:2013-10-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of immunosuppression by the therapeutic antibody daclizumab
Cell Res., 20, 2010
3V9R
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CRYSTAL STRUCTURE OF SACCHAROMYCES CEREVISIAE MHF COMPLEX
Descriptor:Uncharacterized protein YOL086W-A, Uncharacterized protein YDL160C-A, SULFATE ION
Authors:Yang, H., Zhang, T., Zhong, C., Li, H., Zhou, J., Ding, J.
Deposit date:2011-12-28
Release date:2012-02-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Saccharomyces Cerevisiae MHF Complex Structurally Resembles the Histones (H3-H4)(2) Heterotetramer and Functions as a Heterotetramer
Structure, 20, 2012
5H64
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CRYO-EM STRUCTURE OF MTORC1
Descriptor:Serine/threonine-protein kinase mTOR, Regulatory-associated protein of mTOR, Target of rapamycin complex subunit LST8
Authors:Yang, H., Wang, J., Liu, M., Chen, X., Huang, M., Tan, D., Dong, M., Wong, C.C.L., Wang, J., Xu, Y., Wang, H.
Deposit date:2016-11-10
Release date:2017-01-25
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:4.4 angstrom Resolution Cryo-EM structure of human mTOR Complex 1
Protein Cell, 7, 2016
1MIU
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STRUCTURE OF A BRCA2-DSS1 COMPLEX
Descriptor:Deleted in split hand/split foot protein 1, Breast Cancer type 2 susceptibility protein, MERCURY (II) ION
Authors:Yang, H., Jeffrey, P.D., Miller, J., Kinnucan, E., Sun, Y., Thoma, N.H., Zheng, N., Chen, P.L., Lee, W.H., Pavletich, N.P.
Deposit date:2002-08-23
Release date:2002-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure
Science, 297, 2002
1MJE
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STRUCTURE OF A BRCA2-DSS1-SSDNA COMPLEX
Descriptor:5'-D(P*TP*TP*TP*TP*TP*T)-3', Deleted in split hand/split foot protein 1, breast cancer 2
Authors:Yang, H., Jeffrey, P.D., Miller, J., Kinnucan, E., Sun, Y., Thoma, N.H., Zheng, N., Chen, P.L., Lee, W.H., Pavletich, N.P.
Deposit date:2002-08-27
Release date:2002-09-27
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
Science, 297, 2002
1YEM
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CONSERVED HYPOTHETICAL PROTEIN PFU-838710-001 FROM PYROCOCCUS FURIOSUS
Descriptor:Conserved hypothetical protein Pfu-838710-001, PLATINUM (II) ION, UNKNOWN ATOM OR ION
Authors:Yang, H., Chang, J., Shah, A., Ng, J.D., Liu, Z.-J., Chen, L., Lee, D., Tempel, W., Praissman, J.L., Lin, D., Arendall III, W.B., Richardson, J.S., Richardson, D.C., Jenney Jr., F.E., Adams, M.W.W., Rose, J.P., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2004-12-28
Release date:2005-01-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conserved hypothetical protein Pfu-838710-001 from Pyrococcus furiosus
To be published
2IA0
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TRANSCRIPTIONAL REGULATORY PROTEIN PF0864 FROM PYROCOCCUS FURIOSUS A MEMBER OF THE ASNC FAMILY (PF0864)
Descriptor:Putative HTH-type transcriptional regulator PF0864, GOLD ION
Authors:Yang, H., Chang, J., Liu, Z.J., Rose, J.P., Wang, B.C., Southeast Collaboratory for Structural Genomics, Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2006-09-06
Release date:2006-10-31
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Crystal Structure of the Transcriptional Regulatory Protein PF0864: an Asnc Family member from Pyrococcus Furiosus
To be Published
2P9J
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CRYSTAL STRUCTURE OF AQ2171 FROM AQUIFEX AEOLICUS
Descriptor:Hypothetical protein AQ2171
Authors:Yang, H., Chen, L., Agari, Y., Ebihara, A., Shinkai, A., Kuramitsu, S., Yokoyama, S., Rose, J.P., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-03-26
Release date:2007-05-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of AQ2171 from Aquifex aeolicus
To be Published
2QLZ
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CRYSTAL STRUCTURE OF TRANSCRIPTION FACTOR PF0095 FROM PYROCOCCUS FURIOSUS
Descriptor:Transcription Factor PF0095
Authors:Yang, H., Lipscomb, G.L., Scott, R.A., Rose, J.P., Wang, B.C.
Deposit date:2007-07-13
Release date:2008-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of Transcription Factor PF0095 from Pyrococcus furiosus
To be Published
2QUF
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CRYSTAL STRUCTURE OF TRANSCRIPTION FACTOR AXXA-PF0095 FROM PYROCOCCUS FURIOSUS
Descriptor:Transcription Factor PF0095, GLYCEROL
Authors:Yang, H., Lipscomb, G.L., Scott, R.A., Rose, J.P., Wang, B.C.
Deposit date:2007-08-05
Release date:2008-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Transcription Factor AXXA-PF0095 from Pyrococcus furiosus
To be Published