1UJ1 | | CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO) | | Descriptor: | 3C-like proteinase | | Authors: | Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z. | | Deposit date: | 2003-07-25 | | Release date: | 2003-11-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
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1UK2 | | CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO) AT PH8.0 | | Descriptor: | 3C-LIKE PROTEINASE | | Authors: | Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z. | | Deposit date: | 2003-08-14 | | Release date: | 2003-11-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
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1UK3 | | CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO) AT PH7.6 | | Descriptor: | 3C-like proteinase | | Authors: | Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z. | | Deposit date: | 2003-08-14 | | Release date: | 2003-11-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
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1UK4 | | CRYSTAL STRUCTURE OF SARS CORONAVIRUS MAIN PROTEINASE (3CLPRO) COMPLEXED WITH AN INHIBITOR | | Descriptor: | 3C-like proteinase, 5-mer peptide of inhibitor, CHLOROACETONE | | Authors: | Yang, H., Yang, M., Liu, Y., Bartlam, M., Ding, Y., Lou, Z., Sun, L., Zhou, Z., Ye, S., Anand, K., Pang, H., Gao, G.F., Hilgenfeld, R., Rao, Z. | | Deposit date: | 2003-08-14 | | Release date: | 2003-11-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor
Proc.Natl.Acad.Sci.USA, 100, 2003
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1WOF | | CRYSTAL STRUCTURE OF SARS-COV MPRO IN COMPLEX WITH AN INHIBITOR N1 | | Descriptor: | 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]-L-ALANYL-L-VALYL-N~1~-((1S)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE | | Authors: | Yang, H., Bartlam, M., Xue, X., Yang, K., Liang, W., Rao, Z. | | Deposit date: | 2004-08-18 | | Release date: | 2005-08-30 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
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2AMD | | CRYSTAL STRUCTURE OF SARS_COV MPRO IN COMPLEX WITH AN INHIBITOR N9 | | Descriptor: | 3C-like proteinase, N-(3-FUROYL)-D-VALYL-L-VALYL-N~1~-((1R,2Z)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-D-LEUCINAMIDE | | Authors: | Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z. | | Deposit date: | 2005-08-09 | | Release date: | 2005-09-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
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2AMP | | CRYSTAL STRUCTURE OF PORCINE TRANSMISSIBLE GASTROENTERITIS VIRUS MPRO IN COMPLEX WITH AN INHIBITOR N1 | | Descriptor: | 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]-L-ALANYL-L-VALYL-N~1~-((1S)-4-ETHOXY-4-OXO-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE | | Authors: | Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z. | | Deposit date: | 2005-08-10 | | Release date: | 2005-09-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
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2AMQ | | CRYSTAL STRUCTURE OF SARS_COV MPRO IN COMPLEX WITH AN INHIBITOR N3 | | Descriptor: | 3C-like proteinase, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE | | Authors: | Yang, H., Xue, X., Yang, K., Zhao, Q., Bartlam, M., Rao, Z. | | Deposit date: | 2005-08-10 | | Release date: | 2005-09-13 | | Last modified: | 2015-12-09 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
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2D2D | | CRYSTAL STRUCTURE OF SARS-COV MPRO IN COMPLEX WITH AN INHIBITOR I2 | | Descriptor: | 3C-like proteinase, ETHYL (2E,4S)-4-[((2R)-2-{[N-(TERT-BUTOXYCARBONYL)-L-VALYL]AMINO}-2-PHENYLETHANOYL)AMINO]-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENT-2-ENOATE | | Authors: | Yang, H., Bartlam, M., Xue, X., Yang, K., Liang, W., Ding, Y., Rao, Z. | | Deposit date: | 2005-09-08 | | Release date: | 2005-09-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases.
Plos Biol., 3, 2005
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5GXJ | | ZIKA VIRUS NS2B-NS3 PROTEASE | | Descriptor: | FLAVIVIRUS_NS2B,LINKER,Peptidase S7 | | Authors: | Yang, H., Chen, X., Ji, X., Xiong, Y., Yang, K. | | Deposit date: | 2016-09-18 | | Release date: | 2017-05-03 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Viral protease activation mechanism
To Be Published
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3NK6 | | STRUCTURE OF THE NOSIHEPTIDE-RESISTANCE METHYLTRANSFERASE | | Descriptor: | 23S rRNA methyltransferase | | Authors: | Yang, H., Wang, Z., Shen, Y., Wang, P., Murchie, A., Xu, Y. | | Deposit date: | 2010-06-18 | | Release date: | 2010-07-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of the Nosiheptide-Resistance Methyltransferase of Streptomyces actuosus
Biochemistry, 49, 2010
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3NK7 | | STRUCTURE OF THE NOSIHEPTIDE-RESISTANCE METHYLTRANSFERASE S-ADENOSYL-L-METHIONINE COMPLEX | | Descriptor: | 23S rRNA methyltransferase, S-ADENOSYLMETHIONINE | | Authors: | Yang, H., Wang, Z., Shen, Y., Wang, P., Murchie, A., Xu, Y. | | Deposit date: | 2010-06-18 | | Release date: | 2010-07-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of the Nosiheptide-Resistance Methyltransferase of Streptomyces actuosus
Biochemistry, 49, 2010
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1XMA | | STRUCTURE OF A TRANSCRIPTIONAL REGULATOR FROM CLOSTRIDIUM THERMOCELLUM CTH-833 | | Descriptor: | Predicted transcriptional regulator, MERCURY (II) ION, UNKNOWN ATOM OR ION | | Authors: | Yang, H., Chen, L., Lee, D., Habel, J., Nguyen, J., Chang, S.-H., Kataeva, I., Xu, H., Chang, J., Zhao, M., Horanyi, P., Florence, Q., Zhou, W., Tempel, W., Lin, D., Praissman, J., Zhang, H., Arendall III, W.B., Richardson, J.S., Richardson, D.C., Ljungdahl, L., Liu, Z.-J., Rose, J.P., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2004-10-01 | | Release date: | 2004-12-14 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.301 Å) | | Cite: | Structure of a transcriptional regulator from Clostridium thermocellum Cth-833
To be published
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1ZGH | | METHIONYL-TRNA FORMYLTRANSFERASE FROM CLOSTRIDIUM THERMOCELLUM | | Descriptor: | Methionyl-tRNA formyltransferase, UNKNOWN ATOM OR ION | | Authors: | Yang, H., Kataeva, I., Xu, H., Zhao, M., Chang, J., Liu, Z., Chen, L., Tempel, W., Habel, J., Zhou, W., Lee, D., Lin, D., Chang, S., Arendall III, W.B., Richardson, J.S., Richardson, D.C., Rose, J.P., Wang, B., Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2005-04-21 | | Release date: | 2005-05-03 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Methionyl-tRNA formyltransferase from Clostridium thermocellum
To be published
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3NFP | | CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THERAPEUTIC ANTIBODY DACLIZUMAB IN COMPLEX WITH IL-2RA (CD25) ECTODOMAIN | | Descriptor: | Heavy chain of Fab fragment of daclizumab, Light chain of Fab fragment of daclizumab, Interleukin-2 receptor subunit alpha | | Authors: | Yang, H., Wang, J., Du, J., Zhong, C., Guo, Y., Ding, J. | | Deposit date: | 2010-06-10 | | Release date: | 2010-09-15 | | Last modified: | 2013-10-16 | | Method: | X-RAY DIFFRACTION (2.86 Å) | | Cite: | Structural basis of immunosuppression by the therapeutic antibody daclizumab
Cell Res., 20, 2010
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3NFS | | CRYSTAL STRUCTURE THE FAB FRAGMENT OF THERAPEUTIC ANTIBODY DACLIZUMAB | | Descriptor: | Heavy chain of Fab fragment of daclizumab, Light chain of Fab fragment of daclizumab | | Authors: | Yang, H., Wang, J., Du, J., Zhong, C., Guo, Y., Ding, J. | | Deposit date: | 2010-06-10 | | Release date: | 2010-09-15 | | Last modified: | 2013-10-16 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis of immunosuppression by the therapeutic antibody daclizumab
Cell Res., 20, 2010
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3V9R | | CRYSTAL STRUCTURE OF SACCHAROMYCES CEREVISIAE MHF COMPLEX | | Descriptor: | Uncharacterized protein YOL086W-A, Uncharacterized protein YDL160C-A, SULFATE ION | | Authors: | Yang, H., Zhang, T., Zhong, C., Li, H., Zhou, J., Ding, J. | | Deposit date: | 2011-12-28 | | Release date: | 2012-02-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Saccharomyces Cerevisiae MHF Complex Structurally Resembles the Histones (H3-H4)(2) Heterotetramer and Functions as a Heterotetramer
Structure, 20, 2012
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5H64 | | CRYO-EM STRUCTURE OF MTORC1 | | Descriptor: | Serine/threonine-protein kinase mTOR, Regulatory-associated protein of mTOR, Target of rapamycin complex subunit LST8 | | Authors: | Yang, H., Wang, J., Liu, M., Chen, X., Huang, M., Tan, D., Dong, M., Wong, C.C.L., Wang, J., Xu, Y., Wang, H. | | Deposit date: | 2016-11-10 | | Release date: | 2017-01-25 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | 4.4 angstrom Resolution Cryo-EM structure of human mTOR Complex 1
Protein Cell, 7, 2016
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1MIU | | STRUCTURE OF A BRCA2-DSS1 COMPLEX | | Descriptor: | Deleted in split hand/split foot protein 1, Breast Cancer type 2 susceptibility protein, MERCURY (II) ION | | Authors: | Yang, H., Jeffrey, P.D., Miller, J., Kinnucan, E., Sun, Y., Thoma, N.H., Zheng, N., Chen, P.L., Lee, W.H., Pavletich, N.P. | | Deposit date: | 2002-08-23 | | Release date: | 2002-09-25 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA
structure
Science, 297, 2002
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1MJE | | STRUCTURE OF A BRCA2-DSS1-SSDNA COMPLEX | | Descriptor: | 5'-D(P*TP*TP*TP*TP*TP*T)-3', Deleted in split hand/split foot protein 1, breast cancer 2 | | Authors: | Yang, H., Jeffrey, P.D., Miller, J., Kinnucan, E., Sun, Y., Thoma, N.H., Zheng, N., Chen, P.L., Lee, W.H., Pavletich, N.P. | | Deposit date: | 2002-08-27 | | Release date: | 2002-09-27 | | Last modified: | 2017-08-09 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
Science, 297, 2002
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1YEM | | CONSERVED HYPOTHETICAL PROTEIN PFU-838710-001 FROM PYROCOCCUS FURIOSUS | | Descriptor: | Conserved hypothetical protein Pfu-838710-001, PLATINUM (II) ION, UNKNOWN ATOM OR ION | | Authors: | Yang, H., Chang, J., Shah, A., Ng, J.D., Liu, Z.-J., Chen, L., Lee, D., Tempel, W., Praissman, J.L., Lin, D., Arendall III, W.B., Richardson, J.S., Richardson, D.C., Jenney Jr., F.E., Adams, M.W.W., Rose, J.P., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2004-12-28 | | Release date: | 2005-01-11 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Conserved hypothetical protein Pfu-838710-001 from Pyrococcus furiosus
To be published
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2IA0 | | TRANSCRIPTIONAL REGULATORY PROTEIN PF0864 FROM PYROCOCCUS FURIOSUS A MEMBER OF THE ASNC FAMILY (PF0864) | | Descriptor: | Putative HTH-type transcriptional regulator PF0864, GOLD ION | | Authors: | Yang, H., Chang, J., Liu, Z.J., Rose, J.P., Wang, B.C., Southeast Collaboratory for Structural Genomics, Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2006-09-06 | | Release date: | 2006-10-31 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Crystal Structure of the Transcriptional Regulatory Protein PF0864: an Asnc Family member from Pyrococcus Furiosus
To be Published
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2P9J | | CRYSTAL STRUCTURE OF AQ2171 FROM AQUIFEX AEOLICUS | | Descriptor: | Hypothetical protein AQ2171 | | Authors: | Yang, H., Chen, L., Agari, Y., Ebihara, A., Shinkai, A., Kuramitsu, S., Yokoyama, S., Rose, J.P., Wang, B.-C., Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2007-03-26 | | Release date: | 2007-05-29 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of AQ2171 from Aquifex aeolicus
To be Published
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2QLZ | |
2QUF | | CRYSTAL STRUCTURE OF TRANSCRIPTION FACTOR AXXA-PF0095 FROM PYROCOCCUS FURIOSUS | | Descriptor: | Transcription Factor PF0095, GLYCEROL | | Authors: | Yang, H., Lipscomb, G.L., Scott, R.A., Rose, J.P., Wang, B.C. | | Deposit date: | 2007-08-05 | | Release date: | 2008-08-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal Structure of Transcription Factor AXXA-PF0095 from Pyrococcus furiosus
To be Published
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