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1AGN
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X-RAY STRUCTURE OF HUMAN SIGMA ALCOHOL DEHYDROGENASE
Descriptor:HUMAN SIGMA ALCOHOL DEHYDROGENASE, ZINC ION, ACETATE ION, ...
Authors:Hurley, T.D., Xie, P.
Deposit date:1996-06-04
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity.
J.Biol.Chem., 272, 1997
1AG8
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ALDEHYDE DEHYDROGENASE FROM BOVINE MITOCHONDRIA
Descriptor:ALDEHYDE DEHYDROGENASE
Authors:Steinmetz, C.G., Hurley, T.D.
Deposit date:1997-04-03
Release date:1997-10-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion.
Structure, 5, 1997
1A4Z
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ALDEHYDE DEHYDROGENASE FROM BOVINE MITOCHONDRIA COMPLEX WITH NAD (REDUCED) AND SAMARIUM (III)
Descriptor:ALDEHYDE DEHYDROGENASE, SAMARIUM (III) ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Steinmetz, C.G., Hurley, T.D.
Deposit date:1998-02-10
Release date:1998-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion.
Structure, 5, 1997
1CW3
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HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE COMPLEXED WITH NAD+ AND MN2+
Descriptor:MITOCHONDRIAL ALDEHYDE DEHYDROGENASE, MANGANESE (II) ION, MAGNESIUM ION, ...
Authors:Ni, L., Zhou, J., Hurley, T.D., Weiner, H.
Deposit date:1999-08-25
Release date:1999-08-31
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms.
Protein Sci., 8, 1999
1ZMS
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LMP1 PROTEIN BINDS TO TRAF3 AS A STRUCTURAL CD40
Descriptor:TNF receptor associated factor 3, Latent membrane protein 1
Authors:Wu, S.D., Xie, P., Welsh, K., Li, C., Ni, C.-Z., Zhu, X., Reed, J.C., Satterthwait, A.C., Bishop, G.A., Ely, K.R.
Deposit date:2005-05-10
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:LMP1 protein from the Epstein Barr virus is a structural CD40 decoy in B lymphocytes fro binding to TRAF3
J.Biol.Chem., 39, 2005
3CSF
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CRYSTAL STRUCTURE OF PI3K P110GAMMA CATALYTICAL DOMAIN IN COMPLEX WITH ORGANORUTHENIUM INHIBITOR DW2
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, RU-PYRIDOCARBAZOLE-2
Authors:Xie, P., Marmorstein, R.
Deposit date:2008-04-09
Release date:2008-05-27
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity.
Acs Chem.Biol., 3, 2008
3CST
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CRYSTAL STRUCTURE OF PI3K P110GAMMA CATALYTICAL DOMAIN IN COMPLEX WITH ORGANORUTHENIUM INHIBITOR E5E2
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Methylated Ruthenium Pyridocarbazole
Authors:Xie, P., Marmorstein, R.
Deposit date:2008-04-10
Release date:2008-05-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity.
Acs Chem.Biol., 3, 2008
3KVQ
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CRYSTAL STRUCTURE OF VEGFR2 EXTRACELLULAR DOMAIN D7
Descriptor:Vascular endothelial growth factor receptor 2
Authors:Yang, Y., Opatowsky, Y., Xie, P., Schlessinger, J.
Deposit date:2009-11-30
Release date:2010-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling
Proc.Natl.Acad.Sci.USA, 107, 2010
3Q4C
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CRYSTAL STRUCTURE OF WILD TYPE BRAF KINASE DOMAIN IN COMPLEX WITH ORGANOMETALLIC INHIBITOR CNS292
Descriptor:Serine/threonine-protein kinase B-raf, [(1,2,3,4,5,6-eta)-(1S,2R,3R,4R,5S,6S)-1-carboxycyclohexane-1,2,3,4,5,6-hexayl](chloro)(3-methyl-5,7-dioxo-6,7-dihydro-5H-pyrido[2,3-a]pyrrolo[3,4-c]carbazol-12-ide-kappa~2~N~1~,N~12~)ruthenium(1+)
Authors:Xie, P., Streu, C., Qin, J., Pregman, H., Pagano, N., Meggers, E., Marmorstein, R.
Deposit date:2010-12-23
Release date:2011-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase.
Biochemistry, 48, 2009
4E26
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BRAF IN COMPLEX WITH AN ORGANIC INHIBITOR 7898734
Descriptor:Serine/threonine-protein kinase B-raf, 5-chloro-7-[(R)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-ol
Authors:Qin, J., Xie, P., Ventocilla, C., Zhou, G., Vultur, A., Chen, Q., Herlyn, M., Winkler, J., Marmorstein, R.
Deposit date:2012-03-07
Release date:2012-05-09
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Identification of a Novel Family of BRAF(V600E) Inhibitors.
J.Med.Chem., 55, 2012