Author results

1B4P
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CRYSTAL STRUCTURES OF CLASS MU CHIMERIC GST ISOENZYMES M1-2 AND M2-1
Descriptor:PROTEIN (GLUTATHIONE S-TRANSFERASE), SULFATE ION, L-gamma-glutamyl-S-[(9S,10S)-10-hydroxy-9,10-dihydrophenanthren-9-yl]-L-cysteinylglycine
Authors:Xiao, G., Chen, J., Armstrong, R.N., Gilliland, G.L.
Deposit date:1998-12-26
Release date:2003-07-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structures of Class MU Chimeric GST Isoenzymes M1-2 and M2-1
To be Published
1EUG
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE AND ITS COMPLEXES WITH URACIL AND GLYCEROL: STRUCTURE AND GLYCOSYLASE MECHANISM REVISITED
Descriptor:PROTEIN (GLYCOSYLASE)
Authors:Xiao, G., Tordova, M., Jagadeesh, J., Drohat, A.C., Stivers, J.T., Gilliland, G.L.
Deposit date:1998-10-12
Release date:1999-10-12
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.
Proteins, 35, 1999
2EUG
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE AND ITS COMPLEXES WITH URACIL AND GLYCEROL: STRUCTURE AND GLYCOSYLASE MECHANISM REVISITED
Descriptor:PROTEIN (GLYCOSYLASE), URACIL
Authors:Xiao, G., Tordova, M., Jagadeesh, J., Drohat, A.C., Stivers, J.T., Gilliland, G.L.
Deposit date:1998-10-13
Release date:1999-10-13
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.
Proteins, 35, 1999
3EUG
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE AND ITS COMPLEXES WITH URACIL AND GLYCEROL: STRUCTURE AND GLYCOSYLASE MECHANISM REVISITED
Descriptor:PROTEIN (GLYCOSYLASE), GLYCEROL
Authors:Xiao, G., Tordova, M., Jagadeesh, J., Drohat, A.C., Stivers, J.T., Gilliland, G.L.
Deposit date:1998-10-13
Release date:1999-10-13
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.
Proteins, 35, 1999
3FYG
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CRYSTAL STRUCTURE OF TETRADECA-(3-FLUOROTYROSYL)-GLUTATHIONE S-TRANSFERASE
Descriptor:MU CLASS TETRADECA-(3-FLUOROTYROSYL)-GLUTATHIONE S-TRANSFERASE OF ISOENZYME, (9R,10R)-9-(S-GLUTATHIONYL)-10-HYDROXY-9,10-DIHYDROPHENANTHRENE
Authors:Xiao, G., Parsons, J.F., Armstrong, R.N., Gilliland, G.L.
Deposit date:1997-08-07
Release date:1999-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Conformational changes in the crystal structure of rat glutathione transferase M1-1 with global substitution of 3-fluorotyrosine for tyrosine.
J.Mol.Biol., 281, 1998
5EUG
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CRYSTALLOGRAPHIC AND ENZYMATIC STUDIES OF AN ACTIVE SITE VARIANT H187Q OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE: CRYSTAL STRUCTURES OF MUTANT H187Q AND ITS URACIL COMPLEX
Descriptor:PROTEIN (GLYCOSYLASE), URACIL
Authors:Xiao, G., Tordova, M., Drohat, A.C., Jagadeesh, J., Stivers, J.T., Gilliland, G.L.
Deposit date:1998-12-27
Release date:1999-07-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.
Proteins, 35, 1999
6GST
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FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE
Descriptor:MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3, GLUTATHIONE
Authors:Xiao, G., Ji, X., Armstrong, R.N., Gilliland, G.L.
Deposit date:1996-01-26
Release date:1996-11-08
Last modified:2011-12-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase.
Biochemistry, 35, 1996
6GSU
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FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE
Descriptor:MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3, SULFATE ION, L-gamma-glutamyl-S-[(9S,10S)-10-hydroxy-9,10-dihydrophenanthren-9-yl]-L-cysteinylglycine
Authors:Xiao, G., Ji, X., Armstrong, R.N., Gilliland, G.L.
Deposit date:1996-01-26
Release date:1996-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase.
Biochemistry, 35, 1996
6GSV
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FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE
Descriptor:MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3, SULFATE ION, L-gamma-glutamyl-S-[(9S,10S)-10-hydroxy-9,10-dihydrophenanthren-9-yl]-L-cysteinylglycine
Authors:Xiao, G., Ji, X., Armstrong, R.N., Gilliland, G.L.
Deposit date:1996-01-26
Release date:1996-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase.
Biochemistry, 35, 1996
6GSW
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FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE
Descriptor:MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3, SULFATE ION, L-gamma-glutamyl-S-[(9S,10S)-10-hydroxy-9,10-dihydrophenanthren-9-yl]-L-cysteinylglycine
Authors:Xiao, G., Ji, X., Armstrong, R.N., Gilliland, G.L.
Deposit date:1996-01-26
Release date:1996-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase.
Biochemistry, 35, 1996
6GSX
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FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE
Descriptor:MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3, SULFATE ION, L-gamma-glutamyl-S-[(9S,10S)-10-hydroxy-9,10-dihydrophenanthren-9-yl]-L-cysteinylglycine
Authors:Xiao, G., Ji, X., Armstrong, R.N., Gilliland, G.L.
Deposit date:1996-01-26
Release date:1996-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase.
Biochemistry, 35, 1996
6GSY
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FIRST-SPHERE AND SECOND-SPHERE ELECTROSTATIC EFFECTS IN THE ACTIVE SITE OF A CLASS MU GLUTATHIONE TRANSFERASE
Descriptor:MU CLASS GLUTATHIONE S-TRANSFERASE OF ISOENZYME 3-3, GLUTATHIONE
Authors:Xiao, G., Ji, X., Armstrong, R.N., Gilliland, G.L.
Deposit date:1996-01-26
Release date:1996-11-08
Last modified:2011-12-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:First-sphere and second-sphere electrostatic effects in the active site of a class mu gluthathione transferase.
Biochemistry, 35, 1996
4EUG
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CRYSTALLOGRAPHIC AND ENZYMATIC STUDIES OF AN ACTIVE SITE VARIANT H187Q OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE: CRYSTAL STRUCTURES OF MUTANT H187Q AND ITS URACIL COMPLEX
Descriptor:PROTEIN (GLYCOSYLASE)
Authors:Xiao, G., Tordova, M., Drohat, A.C., Jagadeesh, J., Stivers, J.T., Gilliland, G.L.
Deposit date:1998-12-27
Release date:1999-07-23
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187.
Biochemistry, 38, 1999
1FLZ
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URACIL DNA GLYCOSYLASE WITH UAAP
Descriptor:URACIL-DNA GLYCOSYLASE, URACIL
Authors:Werner, R.M., Jiang, Y.L., Gordley, R.G., Jagadeesh, G.J., Ladner, J.E., Xiao, G., Tordova, M., Gilliland, G.L., Stivers, J.T.
Deposit date:2000-08-15
Release date:2001-01-17
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Stressing-out DNA? The contribution of serine-phosphodiester interactions in catalysis by uracil DNA glycosylase.
Biochemistry, 39, 2000
1TDJ
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THREONINE DEAMINASE (BIOSYNTHETIC) FROM E. COLI
Descriptor:BIOSYNTHETIC THREONINE DEAMINASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Gallagher, D.T., Gilliland, G.L., Xiao, G., Eisenstein, E.
Deposit date:1998-03-27
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and control of pyridoxal phosphate dependent allosteric threonine deaminase.
Structure, 6, 1998
1MTC
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GLUTATHIONE TRANSFERASE MUTANT Y115F
Descriptor:Glutathione S-transferase YB1, (9R,10R)-9-(S-GLUTATHIONYL)-10-HYDROXY-9,10-DIHYDROPHENANTHRENE
Authors:Ladner, J.E., Xiao, G., Armstrong, R.N., Gilliland, G.L.
Deposit date:2002-09-20
Release date:2003-03-25
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Local protein dynamics and catalysis: detection of segmental motion associated with rate-limiting product release by a glutathione transferase
Biochemistry, 41, 2002
1N2A
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CRYSTAL STRUCTURE OF A BACTERIAL GLUTATHIONE TRANSFERASE FROM ESCHERICHIA COLI WITH GLUTATHIONE SULFONATE IN THE ACTIVE SITE
Descriptor:Glutathione S-transferase, GLUTATHIONE SULFONIC ACID
Authors:Rife, C.L., Parsons, J.F., Xiao, G., Gilliland, G.L., Armstrong, R.N.
Deposit date:2002-10-22
Release date:2003-11-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Conserved structural elements in glutathione transferase homologues encoded in the genome of Escherichia coli
Proteins, 53, 2003
1QSG
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CRYSTAL STRUCTURE OF ENOYL REDUCTASE INHIBITION BY TRICLOSAN
Descriptor:ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, ALPHA-D-GLUCOSE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Stewart, M.J., Parikh, S., Xiao, G., Tonge, P.J., Kisker, C.
Deposit date:1999-06-21
Release date:1999-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis and mechanism of enoyl reductase inhibition by triclosan.
J.Mol.Biol., 290, 1999
5FWG
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TETRA-(5-FLUOROTRYPTOPHANYL)-GLUTATHIONE TRANSFERASE
Descriptor:TETRA-(5-FLUOROTRYPTOPHANYL)-GLUTATHIONE TRANSFERASE MU CLASS, (9R,10R)-9-(S-GLUTATHIONYL)-10-HYDROXY-9,10-DIHYDROPHENANTHRENE
Authors:Parsons, J.F., Xiao, G., Armstrong, R.N., Gilliland, G.L.
Deposit date:1997-11-08
Release date:1999-01-27
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Enzymes harboring unnatural amino acids: mechanistic and structural analysis of the enhanced catalytic activity of a glutathione transferase containing 5-fluorotryptophan.
Biochemistry, 37, 1998
2JOH
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NMR STRUCTURE OF RABBIT PRION PROTEIN MUTATION S173N
Descriptor:Major prion protein
Authors:Li, J., Lin, D.
Deposit date:2007-03-13
Release date:2008-02-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Unique structural characteristics of the rabbit prion protein.
J.Biol.Chem., 285, 2010
2FJ3
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NMR SOLUTION OF RABBIT PRION PROTEIN (91-228)
Descriptor:Major prion protein
Authors:Li, J., Lin, D.H.
Deposit date:2005-12-31
Release date:2006-12-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Unique structural characteristics of the rabbit prion protein
J.Biol.Chem., 285, 2010
3R21
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DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF PYRAZOLOPYRIDINE-SULFONAMIDES AS POTENT MULTIPLE-MITOTIC KINASE (MMK) INHIBITORS (PART I)
Descriptor:Serine/threonine-protein kinase 6, N-(2-aminoethyl)-N-{5-[(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]pyridin-2-yl}methanesulfonamide, MAGNESIUM ION
Authors:Zhang, L., Fan, J., Chong, J.-H., Cesena, A., Tam, B., Gilson, C., Boykin, C., Wang, D., Marcotte, D., Le Brazidec, J.-Y., Aivazian, D., Piao, J., Lundgren, K., Hong, K., Vu, K., Nguyen, K.
Deposit date:2011-03-11
Release date:2011-08-10
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).
Bioorg.Med.Chem.Lett., 21, 2011
3R22
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DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF PYRAZOLOPYRIDINE-SULFONAMIDES AS POTENT MULTIPLE-MITOTIC KINASE (MMK) INHIBITORS (PART I)
Descriptor:Serine/threonine-protein kinase 6, N-{5-[(1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino]pyridin-2-yl}methanesulfonamide
Authors:Zhang, L., Fan, J., Chong, J.-H., Cesana, A., Tam, B., Gilson, C., Boykin, C., Wang, D., Marcotte, D., Le Brazidec, J.-Y., Aivazian, D., Piao, J., Lundgren, K., Hong, K., Vu, K., Nguyen, K.
Deposit date:2011-03-11
Release date:2011-08-10
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).
Bioorg.Med.Chem.Lett., 21, 2011