Author results

4Q91
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CRYSTAL STRUCTURE OF C16A/K12V/C117V/P134V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, FORMIC ACID, PHOSPHATE ION
Authors:Xia, X., Blaber, M.
Deposit date:2014-04-28
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4XKI
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HUMAN FIBROBLAST GROWTH FACTOR - 1 (FGF-1) MUTANT S116R
Descriptor:Fibroblast growth factor 1, SULFATE ION, PHOSPHATE ION, ...
Authors:Xia, X.
Deposit date:2015-01-12
Release date:2016-01-20
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Biophysical characterizations of Fibroblast Growth Factor - 1 mutant with increased heparin binding affinity
To Be Published
4YOL
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HUMAN FIBROBLAST GROWTH FACTOR-1 C16S/A66C/C117A/P134A
Descriptor:Fibroblast growth factor 1, CITRATE ANION, IMIDAZOLE
Authors:Xia, X., Blaber, M.
Deposit date:2015-03-11
Release date:2016-03-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application.
J.Pharm.Sci., 105, 2016
5HZR
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CRYSTAL STRUCTURE OF MTSNF2
Descriptor:SNF2-family ATP dependent chromatin remodeling factor like protein, 3-(1-methylpiperidinium-1-yl)propane-1-sulfonate, SODIUM ION, ...
Authors:Chen, Z.C., Xia, X.
Deposit date:2016-02-02
Release date:2016-07-20
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structure of chromatin remodeler Swi2/Snf2 in the resting state
Nat.Struct.Mol.Biol., 23, 2016
4Q9G
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CRYSTAL STRUCTURE OF K12V/C16S/C117V/P134V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, FORMIC ACID, PHOSPHATE ION
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-01
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.554 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4Q9P
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CRYSTAL STRUCTURE OF C16T/K12V/C117V/P134V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-01
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QAL
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CRYSTAL STRUCTURE OF C117A MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, CITRATE ANION
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-05
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QBC
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CRYSTAL STRUCTURE OF C117T MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR IN SODIUM FORMATE BUFFER
Descriptor:Fibroblast growth factor 1, SULFATE ION, FORMIC ACID
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-07
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.519 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QBV
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CRYSTAL STRUCTURE OF C117T MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR IN SODIUM CITRATE BUFFER
Descriptor:Fibroblast growth factor 1, CITRATE ANION
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-08
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.497 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QC4
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CRYSTAL STRUCTURE OF C117S MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, CITRATE ANION, SODIUM ION, ...
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-09
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.491 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
5X0X
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COMPLEX OF SNF2-NUCLEOSOME COMPLEX WITH SNF2 BOUND TO POSITION +6 OF THE NUCLEOSOME
Descriptor:Histone H3.2, Histone H4, Histone H2A, ...
Authors:Li, M., Liu, X., Xia, X., Chen, Z., Li, X.
Deposit date:2017-01-23
Release date:2017-04-19
Last modified:2017-06-07
Method:ELECTRON MICROSCOPY (3.97 Å)
Cite:Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure.
Nature, 544, 2017
5X0Y
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COMPLEX OF SNF2-NUCLEOSOME COMPLEX WITH SNF2 BOUND TO SHL2 OF THE NUCLEOSOME
Descriptor:Histone H3.2, Histone H4, Histone H2A, ...
Authors:Li, M., Liu, X., Xia, X., Chen, Z., Li, X.
Deposit date:2017-01-23
Release date:2017-04-19
Last modified:2017-06-07
Method:ELECTRON MICROSCOPY (4.69 Å)
Cite:Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure.
Nature, 544, 2017
2XUT
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CRYSTAL STRUCTURE OF A PROTON DEPENDENT OLIGOPEPTIDE (POT) FAMILY TRANSPORTER.
Descriptor:PROTON/PEPTIDE SYMPORTER FAMILY PROTEIN
Authors:Newstead, S., Drew, D., Cameron, A.D., Postis, V.L., Xia, X., Fowler, P.W., Ingram, J.C., Carpenter, E.P., Sansom, M.S.P., McPherson, M.J., Baldwin, S.A., Iwata, S.
Deposit date:2010-10-21
Release date:2010-12-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.62 Å)
Cite:Crystal Structure of a Prokaryotic Homologue of the Mammalian Oligopeptide-Proton Symporters, Pept1 and Pept2.
Embo J., 30, 2011
4F34
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SYMFOIL-4V SYNTHETIC PROTEIN WITH T30E/T72E/T116E MUTATIONS, AND DELTA HIS TAG
Descriptor:de novo protein Symfoil-4V
Authors:Blaber, M., Xia, X.
Deposit date:2012-05-08
Release date:2013-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Symfoil-4V synthetic protein with T30E/T72E/T116E mutations, and delta His tag
TO BE PUBLISHED
4QO3
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CRYSTAL STRUCTURE OF C16S/N18S/K12V/C117V/P134V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, CITRATE ANION, IMIDAZOLE
Authors:Blaber, M., Xia, X.
Deposit date:2014-06-19
Release date:2015-05-06
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:Thermodynamics of Cysteine Substitution Suggest Unique Structural Role for Cysteine in Proteins
To be Published
5C65
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STRUCTURE OF THE HUMAN GLUCOSE TRANSPORTER GLUT3 / SLC2A3
Descriptor:Solute carrier family 2, facilitated glucose transporter member 3, Octyl Glucose Neopentyl Glycol, ...
Authors:Pike, A.C.W., Quigley, A., Chu, A., Tessitore, A., Xia, X., Mukhopadhyay, S., Wang, D., Kupinska, K., Strain-Damerell, C., Chalk, R., Burgess-Brown, N.A., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2015-06-22
Release date:2015-07-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of the human glucose transporter GLUT3 / SLC2A3
To Be Published
5WLP
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SOLUTION STRUCTURE OF THE PSEUDO-RECEIVER DOMAIN OF ATG32
Descriptor:Autophagy-related protein 32
Authors:Xue, X., Pellegrini, M., Ragusa, M.J.
Deposit date:2017-07-27
Release date:2018-07-04
Last modified:2019-02-20
Method:SOLUTION NMR
Cite:A pseudo-receiver domain in Atg32 is required for mitophagy.
Autophagy, 14, 2018
2YPT
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CRYSTAL STRUCTURE OF THE HUMAN NUCLEAR MEMBRANE ZINC METALLOPROTEASE ZMPSTE24 MUTANT (E336A) IN COMPLEX WITH A SYNTHETIC CSIM TETRAPEPTIDE FROM THE C-TERMINUS OF PRELAMIN A
Descriptor:CAAX PRENYL PROTEASE 1 HOMOLOG, PRELAMIN-A/C, ZINC ION
Authors:Pike, A.C.W., Dong, Y.Y., Quigley, A., Dong, L., Savitsky, P., Cooper, C.D.O., Chaikuad, A., Goubin, S., Shrestha, L., Li, Q., Mukhopadhyay, S., Yang, J., Xia, X., Shintre, C.A., Barr, A.J., Berridge, G., Chalk, R., Bray, J.E., von Delft, F., Bullock, A., Bountra, C., Arrowsmith, C.H., Edwards, A., Burgess-Brown, N., Carpenter, E.P.
Deposit date:2012-11-01
Release date:2012-12-05
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:The Structural Basis of Zmpste24-Dependent Laminopathies.
Science, 339, 2013
4AW6
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CRYSTAL STRUCTURE OF THE HUMAN NUCLEAR MEMBRANE ZINC METALLOPROTEASE ZMPSTE24 (FACE1)
Descriptor:CAAX PRENYL PROTEASE 1 HOMOLOG, ZINC ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Authors:Pike, A.C.W., Dong, Y.Y., Quigley, A., Dong, L., Cooper, C.D.O., Chaikuad, A., Goubin, S., Shrestha, L., Li, Q., Mukhopadhyay, S., Yang, J., Xia, X., Shintre, C.A., Barr, A.J., Berridge, G., Chalk, R., Bray, J.E., von Delft, F., Bullock, A., Bountra, C., Arrowsmith, C.H., Edwards, A., Burgess-Brown, N., Carpenter, E.P.
Deposit date:2012-05-31
Release date:2012-07-25
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The Structural Basis of Zmpste24-Dependent Laminopathies.
Science, 339, 2013
4AYT
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STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10
Descriptor:ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10 MITOCHONDRIAL, GLYCINE, MAGNESIUM ION, ...
Authors:Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P.
Deposit date:2012-06-22
Release date:2012-07-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
4AYW
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STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (PLATE FORM)
Descriptor:ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P.
Deposit date:2012-06-22
Release date:2012-07-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
4AYX
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STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (ROD FORM B)
Descriptor:ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, GLYCINE, MAGNESIUM ION, ...
Authors:Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P.
Deposit date:2012-06-22
Release date:2012-07-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
5JXR
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CRYSTAL STRUCTURE OF MTISWI
Descriptor:Chromatin-remodeling complex ATPase-like protein, CHLORIDE ION
Authors:Chen, Z., Yan, L.
Deposit date:2016-05-13
Release date:2016-12-07
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (2.404 Å)
Cite:Structure and regulation of the chromatin remodeller ISWI
Nature, 540, 2016
5JXT
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CRYSTAL STRUCTURE OF MTISWI BOUND WITH HISTONE H4 TAIL
Descriptor:Chromatin-remodeling complex ATPase-like protein, Histone H4
Authors:Chen, Z., Yan, L.
Deposit date:2016-05-13
Release date:2016-12-07
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (3.009 Å)
Cite:Structure and regulation of the chromatin remodeller ISWI
Nature, 540, 2016