Author results

1GYA
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N-GLYCAN AND POLYPEPTIDE NMR SOLUTION STRUCTURES OF THE ADHESION DOMAIN OF HUMAN CD2
Descriptor:HUMAN CD2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Wyss, D.F., Choi, J.S., Wagner, G.
Deposit date:1995-05-26
Release date:1996-11-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Conformation and function of the N-linked glycan in the adhesion domain of human CD2.
Science, 269, 1995
1CDB
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STRUCTURE OF THE GLYCOSYLATED ADHESION DOMAIN OF HUMAN T LYMPHOCYTE GLYCOPROTEIN CD2
Descriptor:CD2
Authors:Wyss, D.F., Withka, J.M., Recny, M.A., Wagner, G.
Deposit date:1993-09-15
Release date:1994-01-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2.
Structure, 1, 1993
1BWM
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A SINGLE-CHAIN T CELL RECEPTOR
Descriptor:PROTEIN (ALPHA-BETA T CELL RECEPTOR (TCR) (D10))
Authors:Hare, B.J., Wyss, D.F., Reinherz, E.L., Wagner, G.
Deposit date:1998-09-23
Release date:1999-07-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor.
Nat.Struct.Biol., 6, 1999
1JR6
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SOLUTION STRUCTURE OF AN ENGINEERED ARGININE-RICH SUBDOMAIN 2 OF THE HEPATITIS C VIRUS NS3 RNA HELICASE
Descriptor:Helicase NS3
Authors:Liu, D., Wyss, D.F., Wang, Y.S., Gesell, J.J.
Deposit date:2001-08-10
Release date:2002-08-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and backbone dynamics of an engineered arginine-rich subdomain 2 of the hepatitis C virus NS3 RNA helicase.
J.Mol.Biol., 314, 2001
1ONB
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SOLUTION STRUCTURE OF AN ENGINEERED ARGININE-RICH SUBDOMAIN 2 OF THE HEPATITIS C VIRUS NS3 RNA HELICASE
Descriptor:helicase NS3
Authors:Liu, D., Wang, Y.S., Gesell, J.J., Wyss, D.F.
Deposit date:2003-02-27
Release date:2003-03-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and backbone dynamics of an engineered arginine-rich subdomain 2 of the hepatitis C virus NS3 RNA helicase
J.Mol.Biol., 314, 2001
1OVQ
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SOLUTION STRUCTURE OF THE HYPOTHETICAL PROTEIN YQGF FROM ESCHERICHIA COLI
Descriptor:Hypothetical protein yqgF
Authors:Liu, D., Wang, Y.S., Wyss, D.F.
Deposit date:2003-03-27
Release date:2003-11-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the hypothetical protein YqgF from Escherichia coli reveals an RNAse H fold.
J.Biomol.NMR, 27, 2003
1RQ8
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SOLUTION STRUCTURE OF THE HYPOTHETICAL PROTEIN SAV1595 FROM STAPHYLOCOCCUS AUREUS, A PUTATIVE RNA BINDING PROTEIN
Descriptor:conserved hypothetical protein
Authors:Liu, D., Wyss, D.F.
Deposit date:2003-12-04
Release date:2004-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the Hypothetical Protein SAV1595 from Staphylococcus Aureus, a Putative RNA Binding Protein.
J.Biomol.Nmr, 29, 2004
3KMX
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STRUCTURE OF BACE BOUND TO SCH346572
Descriptor:Beta-secretase 1, 4-butoxy-3-chlorobenzyl imidothiocarbamate
Authors:Strickland, C., Wang, Y.
Deposit date:2009-11-11
Release date:2010-01-19
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel muM Leads for the Development of nM BACE-1 (beta-Site APP Cleaving Enzyme 1) Inhibitors.
J.Med.Chem., 53, 2010
3KMY
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STRUCTURE OF BACE BOUND TO SCH12472
Descriptor:Beta-secretase 1, 3-[2-(3-chlorophenyl)ethyl]pyridin-2-amine
Authors:Strickland, C., Wang, Y.
Deposit date:2009-11-11
Release date:2010-01-19
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel muM Leads for the Development of nM BACE-1 (beta-Site APP Cleaving Enzyme 1) Inhibitors.
J.Med.Chem., 53, 2010
3KN0
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STRUCTURE OF BACE BOUND TO SCH708236
Descriptor:Beta-secretase 1, 3-[2-(3-{[(furan-2-ylmethyl)(methyl)amino]methyl}phenyl)ethyl]pyridin-2-amine, L(+)-TARTARIC ACID
Authors:Strickland, C., Wang, Y.
Deposit date:2009-11-11
Release date:2010-01-19
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel muM Leads for the Development of nM BACE-1 (beta-Site APP Cleaving Enzyme 1) Inhibitors.
J.Med.Chem., 53, 2010
3L58
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STRUCTURE OF BACE BOUND TO SCH589432
Descriptor:Beta-secretase 1, N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L59
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STRUCTURE OF BACE BOUND TO SCH710413
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, (2Z)-3-(3-chlorobenzyl)-2-imino-5,5-dimethylimidazolidin-4-one
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5B
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STRUCTURE OF BACE BOUND TO SCH713601
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, (2Z,5R)-3-(3-chlorobenzyl)-2-imino-5-methyl-5-(2-methylpropyl)imidazolidin-4-one
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5C
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STRUCTURE OF BACE BOUND TO SCH723871
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, 1-(4-cyanophenyl)-3-(4-{[(2Z,4R)-2-imino-4-methyl-4-(2-methylpropyl)-5-oxoimidazolidin-1-yl]methyl}benzyl)urea
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5D
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STRUCTURE OF BACE BOUND TO SCH723873
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, 1-butyl-3-(4-{[(2Z,4R)-2-imino-4-methyl-4-(2-methylpropyl)-5-oxoimidazolidin-1-yl]methyl}benzyl)urea
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5E
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STRUCTURE OF BACE BOUND TO SCH736062
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, (4S)-1-(4-{[(2Z,4R)-4-(2-cyclohexylethyl)-4-(cyclohexylmethyl)-2-imino-5-oxoimidazolidin-1-yl]methyl}benzyl)-4-propylimidazolidin-2-one
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010
3L5F
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STRUCTURE OF BACE BOUND TO SCH736201
Descriptor:Beta-secretase 1, D(-)-TARTARIC ACID, (2E,5R)-5-(2-cyclohexylethyl)-5-(cyclohexylmethyl)-2-imino-3-methylimidazolidin-4-one
Authors:Strickland, C., Zhu, Z.
Deposit date:2009-12-21
Release date:2010-02-16
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation
J.Med.Chem., 53, 2010