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1VYB
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BU of 1vyb by Molmil
Endonuclease domain of human LINE1 ORF2p
Descriptor: GLYCEROL, ORF2 CONTAINS A REVERSE TRANSCRIPTASE DOMAIN, SULFATE ION, ...
Authors:Weichenrieder, O, Repanas, K, Perrakis, A.
Deposit date:2004-04-25
Release date:2004-06-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon.
Structure, 12, 2004
1E8S
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BU of 1e8s by Molmil
Alu domain of the mammalian SRP (potential Alu retroposition intermediate)
Descriptor: 7SL RNA, 88-MER, EUROPIUM (III) ION, ...
Authors:Weichenrieder, O, Wild, K, Strub, K, Cusack, S.
Deposit date:2000-09-29
Release date:2000-11-08
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structure and Assembly of the Alu Domain of the Mammalian Signal Recognition Particle
Nature, 408, 2000
1E8O
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BU of 1e8o by Molmil
Core of the Alu domain of the mammalian SRP
Descriptor: 7SL RNA, SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN, SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN, ...
Authors:Weichenrieder, O, Wild, K, Strub, K, Cusack, S.
Deposit date:2000-09-28
Release date:2000-11-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure and Assembly of the Alu Domain of the Mammalian Signal Recognition Particle
Nature, 408, 2000
5FU6
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BU of 5fu6 by Molmil
NOT module of the human CCR4-NOT complex (Crystallization mutant)
Descriptor: CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 2, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3
Authors:Raisch, T, Bhandari, D, Sabath, K, Helms, S, Valkov, E, Weichenrieder, O, Izaurralde, E.
Deposit date:2016-01-21
Release date:2016-03-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Distinct Modes of Recruitment of the Ccr4-not Complex by Drosophila and Vertebrate Nanos
Embo J., 35, 2016
4WBQ
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BU of 4wbq by Molmil
Crystal structure of the exonuclease domain of QIP (QDE-2 interacting protein) solved by native-SAD phasing.
Descriptor: CALCIUM ION, QDE-2-interacting protein
Authors:Boland, A, Weinert, T, Weichenrieder, O, Wang, M.
Deposit date:2014-09-03
Release date:2014-12-10
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.693 Å)
Cite:Fast native-SAD phasing for routine macromolecular structure determination.
Nat.Methods, 12, 2015
7AX1
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BU of 7ax1 by Molmil
Crystal structure of the human CCR4-CAF1 complex
Descriptor: CCR4-NOT transcription complex subunit 6, CCR4-NOT transcription complex subunit 7, MAGNESIUM ION
Authors:Chen, Y, Khazina, E, Weichenrieder, O.
Deposit date:2020-11-09
Release date:2021-05-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex.
Nucleic Acids Res., 49, 2021
5J3Q
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BU of 5j3q by Molmil
Crystal structure of S. pombe Dcp1:Edc1 mRNA decapping complex
Descriptor: Edc1, mRNA-decapping enzyme subunit 1
Authors:Valkov, E, Muthukumar, S, Chang, C.T, Jonas, S, Weichenrieder, O, Izaurralde, E.
Deposit date:2016-03-31
Release date:2016-05-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation.
Nat.Struct.Mol.Biol., 23, 2016
2CKL
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BU of 2ckl by Molmil
Ring1b-Bmi1 E3 catalytic domain structure
Descriptor: IODIDE ION, POLYCOMB GROUP RING FINGER PROTEIN 4, UBIQUITIN LIGASE PROTEIN RING2, ...
Authors:Buchwald, G, van der Stoop, P, Weichenrieder, O, Perrakis, A, van Lohuizen, M, Sixma, T.K.
Deposit date:2006-04-20
Release date:2006-05-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and E3-Ligase Activity of the Ring-Ring Complex of Polycomb Proteins Bmi1 and Ring1B.
Embo J., 25, 2006
5FU7
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BU of 5fu7 by Molmil
drosophila nanos NBR peptide bound to the NOT module of the human CCR4-NOT complex
Descriptor: CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 2, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3, ...
Authors:Raisch, T, Bhandari, D, Sabath, K, Helms, S, Valkov, E, Weichenrieder, O, Izaurralde, E.
Deposit date:2016-01-21
Release date:2016-03-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Distinct Modes of Recruitment of the Ccr4-not Complex by Drosophila and Vertebrate Nanos
Embo J., 35, 2016
2WX3
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BU of 2wx3 by Molmil
Asymmetric trimer of the human DCP1a C-terminal domain
Descriptor: MRNA-DECAPPING ENZYME 1A
Authors:Tritschler, F, Motz, C, Weichenrieder, O.
Deposit date:2009-11-01
Release date:2009-12-01
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Dcp1 Forms Asymmetric Trimers to Assemble Into Active Mrna Decapping Complexes in Metazoa.
Proc.Natl.Acad.Sci.USA, 106, 2009
2XES
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BU of 2xes by Molmil
Human PatL1 C-terminal domain (loop variant)
Descriptor: POTASSIUM ION, PROTEIN PAT1 HOMOLOG 1, THIOCYANATE ION
Authors:Tritschler, F, Weichenrieder, O.
Deposit date:2010-05-17
Release date:2010-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The C-Terminal Alpha-Alpha Superhelix of Pat is Required for Mrna Decapping in Metazoa.
Embo J., 29, 2010
2XDY
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BU of 2xdy by Molmil
Crystal structure of the N. crassa QDE-2 AGO MID domain
Descriptor: GLYCEROL, POST-TRANSCRIPTIONAL GENE SILENCING PROTEIN QDE-2, SULFATE ION
Authors:Boland, A, Tritschler, F, Weichenrieder, O.
Deposit date:2010-05-10
Release date:2010-06-16
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure and Ligand Binding of the Mid Domain of a Eukaryotic Argonaute Protein.
Embo Rep., 11, 2010
2XEQ
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BU of 2xeq by Molmil
Human PatL1 C-terminal domain
Descriptor: PAT1 HOMOLOG 1,
Authors:Tritschler, F, Weichenrieder, O.
Deposit date:2010-05-17
Release date:2010-06-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The C-Terminal Alpha-Alpha Superhelix of Pat is Required for Mrna Decapping in Metazoa.
Embo J., 29, 2010
4CZW
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BU of 4czw by Molmil
Structure of the Neurospora crassa Pan2 catalytic unit (protease and nuclease domain)
Descriptor: PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN2, ZINC ION
Authors:Christie, M, Izaurralde, E, Weichenrieder, O.
Deposit date:2014-04-22
Release date:2014-06-04
Last modified:2014-07-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:An Asymmetric Pan3 Dimer Recruits a Single Pan2 Exonuclease to Mediate Mrna Deadenylation and Decay.
Nat.Struct.Mol.Biol., 21, 2014
4CZX
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BU of 4czx by Molmil
Complex of Neurospora crassa PAN2 (WD40) with PAN3 (C-TERM)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN2, ...
Authors:Jonas, S, Izaurralde, E, Weichenrieder, O.
Deposit date:2014-04-22
Release date:2014-06-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:An Asymmetric Pan3 Dimer Recruits a Single Pan2 Exonuclease to Mediate Mrna Deadenylation and Decay.
Nat.Struct.Mol.Biol., 21, 2014
4CRW
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BU of 4crw by Molmil
Complex of human DDX6 (RECA-C) and CNOT1 (MIF4G)
Descriptor: CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, GLYCEROL, PROBABLE ATP-DEPENDENT RNA HELICASE DDX6
Authors:Chen, Y, Boland, A, Izaurralde, E, Weichenrieder, O.
Deposit date:2014-03-01
Release date:2014-05-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A Ddx6-Cnot1 Complex and W-Binding Pockets in Cnot9 Reveal Direct Links between Mirna Target Recognition and Silencing
Mol.Cell, 54, 2014
4CZV
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BU of 4czv by Molmil
Structure of the Neurospora crassa Pan2 WD40 domain
Descriptor: CHLORIDE ION, GLYCEROL, PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN2
Authors:Peter, D, Jonas, S, Izaurralde, E, Weichenrieder, O.
Deposit date:2014-04-22
Release date:2014-06-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An Asymmetric Pan3 Dimer Recruits a Single Pan2 Exonuclease to Mediate Mrna Deadenylation and Decay.
Nat.Struct.Mol.Biol., 21, 2014
4CZY
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BU of 4czy by Molmil
Complex of Neurospora crassa PAN2 (WD40-CS1) with PAN3 (pseudokinase and C-term)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN2, ...
Authors:Jonas, S, Izaurralde, E, Weichenrieder, O.
Deposit date:2014-04-22
Release date:2014-06-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:An Asymmetric Pan3 Dimer Recruits a Single Pan2 Exonuclease to Mediate Mrna Deadenylation and Decay.
Nat.Struct.Mol.Biol., 21, 2014
5ONA
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BU of 5ona by Molmil
Drosophila Bag-of-marbles CBM peptide bound to human CAF40-CNOT1
Descriptor: CCR4-NOT transcription complex subunit 1, CCR4-NOT transcription complex subunit 9, CHLORIDE ION, ...
Authors:Raisch, T, Sgromo, A, Backhaus, C, Izaurralde, E, Weichenrieder, O.
Deposit date:2017-08-03
Release date:2017-12-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:DrosophilaBag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets.
RNA, 24, 2018
5ONB
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BU of 5onb by Molmil
Drosophila Bag-of-marbles CBM peptide bound to human CAF40
Descriptor: CCR4-NOT transcription complex subunit 9, GLYCEROL, Protein bag-of-marbles
Authors:Raisch, T, Sgromo, A, Backhaus, C, Izaurralde, E, Weichenrieder, O.
Deposit date:2017-08-03
Release date:2017-12-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:DrosophilaBag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets.
RNA, 24, 2018
5J3Y
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BU of 5j3y by Molmil
Crystal structure of S. pombe Dcp2:Dcp1 mRNA decapping complex
Descriptor: mRNA decapping complex subunit 2, mRNA-decapping enzyme subunit 1
Authors:Valkov, E, Muthukumar, S, Chang, C.T, Jonas, S, Weichenrieder, O, Izaurralde, E.
Deposit date:2016-03-31
Release date:2016-05-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.288 Å)
Cite:Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation.
Nat.Struct.Mol.Biol., 23, 2016
4D0K
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BU of 4d0k by Molmil
Complex of Chaetomium thermophilum PAN2 (WD40-CS1) with PAN3 (C-term)
Descriptor: A-SPECIFIC RIBONUCLEASE SUBUNIT PAN2, PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN3-LIKE PROTEIN
Authors:Jonas, S, Izaurralde, E, Weichenrieder, O.
Deposit date:2014-04-28
Release date:2014-06-04
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:An Asymmetric Pan3 Dimer Recruits a Single Pan2 Exonuclease to Mediate Mrna Deadenylation and Decay.
Nat.Struct.Mol.Biol., 21, 2014
5J3T
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BU of 5j3t by Molmil
Crystal structure of S. pombe Dcp2:Dcp1:Edc1 mRNA decapping complex
Descriptor: Edc1, FORMIC ACID, MAGNESIUM ION, ...
Authors:Valkov, E, Muthukumar, S, Chang, C.T, Jonas, S, Weichenrieder, O, Izaurralde, E.
Deposit date:2016-03-31
Release date:2016-05-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation.
Nat.Struct.Mol.Biol., 23, 2016
4GMJ
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BU of 4gmj by Molmil
Structure of human NOT1 MIF4G domain co-crystallized with CAF1
Descriptor: CCR4-NOT transcription complex subunit 1, CCR4-NOT transcription complex subunit 7, CHLORIDE ION, ...
Authors:Petit, P, Weichenrieder, O, Wohlbold, L, Izaurralde, E.
Deposit date:2012-08-16
Release date:2012-10-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex
Nucleic Acids Res., 40, 2012
5LSW
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BU of 5lsw by Molmil
A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cell differentiation protein RCD1 homolog, LD12033p, ...
Authors:Sgromo, A, Raisch, T, Bawankar, P, Bhandari, D, Chen, Y, Kuzuoglu-Ozturk, D, Weichenrieder, O, Izaurralde, E.
Deposit date:2016-09-05
Release date:2017-02-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin.
Nat Commun, 8, 2017

 

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