6BIT
| SIRPalpha antibody complex | Descriptor: | KWAR23 Fab heavy chain, KWAR23 Fab light chain, Tyrosine-protein phosphatase non-receptor type substrate 1 | Authors: | Ring, N.G, Herndler-Brandstetter, D, Weiskopf, K, Shan, L, Volkmer, J.P, George, B.M, Lietzenmayer, M, McKenna, K.M, Naik, T.J, McCarty, A, Zheng, Y, Ring, A.M, Flavell, R.A, Weissman, I.L. | Deposit date: | 2017-11-03 | Release date: | 2017-12-06 | Last modified: | 2019-11-20 | Method: | X-RAY DIFFRACTION (2.191 Å) | Cite: | Anti-SIRP alpha antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5IWL
| CD47-diabody complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5F9 diabody, Leukocyte surface antigen CD47, ... | Authors: | Di, W, Jude, K.M, Garcia, K.C. | Deposit date: | 2016-03-22 | Release date: | 2016-06-29 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. J.Clin.Invest., 126, 2016
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4KJY
| Complex of high-affinity SIRP alpha variant FD6 with CD47 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, High-affinity SIRPa variant FD6, Leukocyte surface antigen CD47, ... | Authors: | Ring, A.M, Ozkan, E, Ho, C.C.M, Garcia, K.C. | Deposit date: | 2013-05-04 | Release date: | 2013-06-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Engineered SIRP alpha variants as immunotherapeutic adjuvants to anticancer antibodies. Science, 341, 2013
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