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4AWI
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BU of 4awi by Molmil
Human Jnk1alpha kinase with 4-phenyl-7-azaindole IKK2 inhibitor.
Descriptor: MITOGEN-ACTIVATED PROTEIN KINASE 8, N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-4-[2-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide, SULFATE ION
Authors:Chung, C, Vicentini, G, Liddle, J, Bamborough, P.
Deposit date:2012-06-03
Release date:2013-05-01
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:4-Phenyl-7-Azaindoles as Potent, Selective and Bioavailable Ikk2 Inhibitors Demonstrating Good in Vivo Efficacy.
Bioorg.Med.Chem.Lett., 22, 2012
2IXM
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BU of 2ixm by Molmil
Structure of human PTPA
Descriptor: SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'
Authors:Leulliot, N, Vicentini, G, Jordens, J, Quevillon-Cheruel, S, Schiltz, M, Barford, D, Van Tilbeurgh, H, Goris, J.
Deposit date:2006-07-09
Release date:2006-07-11
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of the Pp2A Phosphatase Activator: Implications for its Pp2A-Specific Ppiase Activity
Mol.Cell, 23, 2006
2IXN
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BU of 2ixn by Molmil
CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR Ypa2 PTPA2
Descriptor: SERINE/THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2
Authors:Leulliot, N, Vicentini, G, Jordens, J, Quevillon-Cheruel, S, Schiltz, M, Barford, D, Van Tilbeurgh, H, Goris, J.
Deposit date:2006-07-09
Release date:2006-07-31
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Pp2A Phosphatase Activator: Implications for its Pp2A-Specific Ppiase Activity
Mol.Cell, 23, 2006
2IXP
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BU of 2ixp by Molmil
Crystal structure of the Pp2A phosphatase activator Ypa1 PTPA1 in complex with model substrate
Descriptor: CHLORIDE ION, SERINE/THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1, SIN-ALA-ALA-PRO-LYS-NIT, ...
Authors:Leulliot, N, Vicentini, G, Jordens, J, Quevillon-Cheruel, S, Schiltz, M, Barford, D, Van Tilbeurgh, H, Goris, J.
Deposit date:2006-07-09
Release date:2006-07-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity.
Mol. Cell, 23, 2006
2IXO
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BU of 2ixo by Molmil
CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR Ypa1 PTPA1
Descriptor: SERINE/THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1
Authors:Leulliot, N, Vicentini, G, Jordens, J, Quevillon-Cheruel, S, Schiltz, M, Barford, D, Van Tilbeurgh, H, Goris, J.
Deposit date:2006-07-09
Release date:2006-07-31
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Pp2A Phosphatase Activator: Implications for its Pp2A-Specific Ppiase Activity.
Mol.Cell, 23, 2006
5OBF
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BU of 5obf by Molmil
fAb. AbVance: increasing our knowledge of antibody structural space to enable faster and better decision-making in antibody drug discovery.
Descriptor: GLYCEROL, SULFATE ION, fAb Heavy chain, ...
Authors:Vicentini, G, Convery, M.A.
Deposit date:2017-06-26
Release date:2017-11-08
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:AbVance: increasing our knowledge of antibody structural space to enable faster and better decision-making in antibody drug discovery
To Be Published
3ELJ
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BU of 3elj by Molmil
Jnk1 complexed with a bis-anilino-pyrrolopyrimidine inhibitor.
Descriptor: 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide, Mitogen-activated protein kinase 8
Authors:Chamberlain, S, Atkins, C, Deanda, F, Dumble, M, Gerding, R, Groy, A, Korenchuk, S, Kumar, R, Lei, H, Mook, R, Moorthy, G, Redman, A, Rowland, J, Shewchuk, L, Vicentini, G, Mosley, J.
Deposit date:2008-09-22
Release date:2008-12-30
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity.
Bioorg.Med.Chem.Lett., 19, 2009

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