Author results

2BKZ
  • Download 2bkz
  • View 2bkz
Molmil generated image of 2bkz
STRUCTURE OF CDK2-CYCLIN A WITH PHA-404611
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, 1-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDE, ...
Authors:DAlessio, R., Bargiottia, A., Metz, S., Brasca, M.G., Cameron, A., Ermoli, A., Marsiglio, A., Polucci, P., Roletto, F., Tibolla, M., Vazquez, M.L., Vulpetti, A., Pevarello, P.
Deposit date:2005-02-23
Release date:2006-03-08
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Benzodipyrazoles: A New Class of Potent Cdk2 Inhibitors
Bioorg.Med.Chem.Lett., 15, 2005
6BBU
  • Download 6bbu
  • View 6bbu
Molmil generated image of 6bbu
CRYSTAL STRUCTURE OF JAK1 IN COMPLEX WITH COMPOUND 25
Descriptor:Tyrosine-protein kinase JAK1, N-{cis-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide
Authors:Han, S.
Deposit date:2017-10-19
Release date:2018-01-17
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.
J. Med. Chem., 61, 2018
6BBV
  • Download 6bbv
  • View 6bbv
Molmil generated image of 6bbv
CRYSTAL STRUCTURE OF JAK2 IN COMPLEX WITH COMPOUND 25
Descriptor:Tyrosine-protein kinase JAK2, N-{cis-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide
Authors:Han, S.
Deposit date:2017-10-19
Release date:2018-01-17
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.
J. Med. Chem., 61, 2018
5KHW
  • Download 5khw
  • View 5khw
Molmil generated image of 5khw
CRYSTAL STRUCTURE OF JAK1 IN COMPLEX WITH ADP
Descriptor:Tyrosine-protein kinase JAK1, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Han, S., Caspers, N.L.
Deposit date:2016-06-16
Release date:2016-11-09
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system.
Acta Crystallogr F Struct Biol Commun, 72, 2016
5KHX
  • Download 5khx
  • View 5khx
Molmil generated image of 5khx
CRYSTAL STRUCTURE OF JAK1 IN COMPLEX WITH PF-4950736
Descriptor:Tyrosine-protein kinase JAK1, ~{N}-[3-[methyl(7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide
Authors:Han, S., Caspers, N.L.
Deposit date:2016-06-16
Release date:2016-11-09
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system.
Acta Crystallogr F Struct Biol Commun, 72, 2016