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2JF2
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NUCLEOTIDE SUBSTRATE BINDING BY UDP-N-ACETYLGLUCOSAMINE ACYLTRANSFERASE
Descriptor:ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE, DI(HYDROXYETHYL)ETHER, 1,2-ETHANEDIOL
Authors:Ulaganathan, V., Buetow, L., Hunter, W.N.
Deposit date:2007-01-25
Release date:2007-04-24
Last modified:2013-12-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Nucleotide Substrate Recognition by Udp-N-Acetylglucosamine Acyltransferase (Lpxa) in the First Step of Lipid a Biosynthesis.
J.Mol.Biol., 369, 2007
2JF3
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NUCLEOTIDE SUBSTRATE BINDING BY UDP-N-ACETYLGLUCOSAMINE ACYLTRANSFERASE
Descriptor:ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE
Authors:Ulaganathan, V., Buetow, L., Hunter, W.N.
Deposit date:2007-01-25
Release date:2007-04-24
Last modified:2013-12-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Nucleotide Substrate Recognition by Udp-N-Acetylglucosamine Acyltransferase (Lpxa) in the First Step of Lipid a Biosynthesis.
J.Mol.Biol., 369, 2007
2UZF
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS 1,4-DIHYDROXY-2-NAPHTHOYL COA SYNTHASE (MENB) IN COMPLEX WITH ACETOACETYL COA
Descriptor:NAPHTHOATE SYNTHASE, ACETOACETYL-COENZYME A
Authors:Ulaganathan, V., Buetow, L., Hunter, W.N.
Deposit date:2007-04-27
Release date:2007-11-13
Last modified:2012-06-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of Staphylococcus Aureus1,4-Dihydroxy-2-Naphthoyl-Coa Synthase (Menb) in Complex with Acetoacetyl-Coa.
Acta Crystallogr.,Sect.F, 63, 2007
3ZCW
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EG5 - NEW ALLOSTERIC BINDING SITE
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ulaganathan, V., Talapatra, S.K., Kozielski, F., Pannifer, A.D.
Deposit date:2012-11-23
Release date:2013-01-23
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.691 Å)
Cite:Structural Insights Into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein.
J.Am.Chem.Soc., 135, 2013
2WOG
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INTERMEDIATE AND FINAL STATES OF HUMAN KINESIN EG5 IN COMPLEX WITH S-TRITYL-L-CYSTEINE
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Hackney, D.D., Kozielski, F.
Deposit date:2009-07-23
Release date:2010-08-04
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:An Allosteric Transition Trapped in an Intermediate State of a New Kinesin-Inhibitor Complex.
Biochem.J., 425, 2010
2X2R
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((4-CHLOROPHENYL)DIPHENYLMETHYLTHIO)PROPANOIC ACID
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, (2R)-2-AMINO-3-[(2R)-2-METHYL-1,1-DIPHENYL-BUTYL]SULFANYL-PROPANOIC ACID, ...
Authors:Kaan, H.Y.K., Weiss, J., Menger, D., Ulaganathan, V., Laggner, C., Popowycz, F., Joseph, B., Kozielski, F.
Deposit date:2010-01-15
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
J.Med.Chem., 54, 2011
2X7C
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (S)-ENASTRON
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
2X7D
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (S)-DIMETHYLENASTRON
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
2X7E
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-FLUORASTROL
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
2XAE
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((S)-2-METHYL-1,1-DIPHENYLBUTYLTHIO)PROPANOIC ACID
Descriptor:KINESIN-LIKE PROTEIN KIF11, (2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC ACID, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Weiss, J., Menger, D., Ulaganathan, V., Tkocz, K., Laggner, C., Popowycz, F., Joseph, B., Kozielski, F.
Deposit date:2010-03-31
Release date:2011-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
J.Med.Chem., 54, 2011
3ELC
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CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CLYCODIPHOSPHATE SYNTHASE COMPLEXED WITH LIGAND
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-pyrimidin-2-one, ...
Authors:Hunter, W.N., Ramsden, N.L., Ulaganathan, V.
Deposit date:2008-09-22
Release date:2009-08-25
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy
J.Med.Chem., 52, 2009
4BN2
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THE CRYSTAL STRUCTURE OF KINESIN-LIKE PROTEIN KIF15
Descriptor:KINESIN-LIKE PROTEIN KIF15, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Klejnot, M., Falnikar, A., Ulaganathan, V., Cross, R., Baas, P., Kozielski, F.
Deposit date:2013-05-13
Release date:2014-01-15
Last modified:2014-01-22
Method:X-RAY DIFFRACTION (2.695 Å)
Cite:The Crystal Structure and Biochemical Characterization of Kif15: A Bifunctional Molecular Motor Involved in Bipolar Spindle Formation and Neuronal Development
Acta Crystallogr.,Sect.D, 70, 2014
3EOR
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CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CLYCODIPHOSPHATE SYNTHASE COMPLEXED WITH LIGAND
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, SODIUM ION, ...
Authors:Hunter, W.N., Ramsden, N.L., Dawson, A.
Deposit date:2008-09-29
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy
J.Med.Chem., 52, 2009
3ERN
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CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CLYCODIPHOSPHATE SYNTHASE COMPLEXED WITH ARACMP
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, CYTOSINE ARABINOSE-5'-PHOSPHATE, ...
Authors:Hunter, W.N., Ramsden, N.L., Kemp, L.A.
Deposit date:2008-10-02
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy
J.Med.Chem., 52, 2009
3ESJ
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CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CLYCODIPHOSPHATE SYNTHASE COMPLEXED WITH LIGAND
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, 4-amino-1-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrimidin-2(1H)-one, ...
Authors:Hunter, W.N., Ramsden, N.L.
Deposit date:2008-10-06
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy
J.Med.Chem., 52, 2009
3FBA
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CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CLYCODIPHOSPHATE SYNTHASE COMPLEXED WITH LIGAND
Descriptor:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, ZINC ION, [(2S,3S,4R,5S)-5-(4-amino-2-oxo-pyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate, ...
Authors:Hunter, W.N., Ramsden, N.L.
Deposit date:2008-11-19
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy
J.Med.Chem., 52, 2009