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9BXI
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BU of 9bxi by Molmil
Paired Helical Filament of tau amyloids found in Down Syndrome individuals
Descriptor: Microtubule-associated protein tau
Authors:Tse, E, Ghosh, U, Condello, C, Southworth, D.
Deposit date:2024-05-22
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold.
Acta Neuropathol Commun, 12, 2024
9BXO
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BU of 9bxo by Molmil
Straight Filament of tau amyloids found in Down Syndrome individuals
Descriptor: Microtubule-associated protein tau
Authors:Tse, E, Ghosh, U, Condello, C, Southworth, D.
Deposit date:2024-05-22
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold.
Acta Neuropathol Commun, 12, 2024
9BXR
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BU of 9bxr by Molmil
Straight Filaments purified from Down Syndrome individual brain tissue applied to graphene oxide antibody affinity grids
Descriptor: Microtubule-associated protein tau
Authors:Tse, E, Ghosh, U, Condello, C, Southworth, D.
Deposit date:2024-05-22
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold.
Acta Neuropathol Commun, 12, 2024
9BXQ
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BU of 9bxq by Molmil
Paired Helical Filaments purified from Down Syndrome individual brain tissue applied to graphene oxide antibody affinity grids
Descriptor: Microtubule-associated protein tau
Authors:Tse, E, Ghosh, U, Condello, C, Southworth, D.
Deposit date:2024-05-22
Release date:2024-08-14
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold.
Acta Neuropathol Commun, 12, 2024
5L9A
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BU of 5l9a by Molmil
L-threonine dehydrogenase from trypanosoma brucei.
Descriptor: ACETATE ION, L-threonine 3-dehydrogenase
Authors:Erskine, P.T, Cooper, J.B, Adjogatse, E, Kelly, J, Wood, S.P.
Deposit date:2016-06-09
Release date:2016-06-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
5LC1
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BU of 5lc1 by Molmil
L-threonine dehydrogenase from Trypanosoma brucei with NAD and the inhibitor pyruvate bound.
Descriptor: ACETATE ION, BETA-MERCAPTOETHANOL, L-threonine 3-dehydrogenase, ...
Authors:Erskine, P.T, Adjogatse, E, Wood, S.P, Cooper, J.B.
Deposit date:2016-06-18
Release date:2016-07-27
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
6W20
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BU of 6w20 by Molmil
ClpAP Disengaged State bound to RepA-GFP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ...
Authors:Lopez, K.L, Rizo, A.N, Tse, E, Lin, J, Scull, N.W, Thwin, A.C, Lucius, A.L, Shorter, J, Southworth, D.R.
Deposit date:2020-03-04
Release date:2020-05-06
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
6W21
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BU of 6w21 by Molmil
ClpAP Engaged2 State bound to RepA-GFP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ...
Authors:Lopez, K.L, Rizo, A.N, Tse, E, Lin, J, Scull, N.W, Thwin, A.C, Lucius, A.L, Shorter, J, Southworth, D.R.
Deposit date:2020-03-04
Release date:2020-05-13
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
6W22
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BU of 6w22 by Molmil
ClpA Engaged1 State bound to RepA-GFP (ClpA Focused Refinement)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ...
Authors:Lopez, K.L, Rizo, A.N, Tse, E, Lin, J, Scull, N.W, Thwin, A.C, Lucius, A.L, Shorter, J, Southworth, D.R.
Deposit date:2020-03-04
Release date:2020-04-29
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
6W1Z
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BU of 6w1z by Molmil
ClpAP Engaged1 State bound to RepA-GFP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ...
Authors:Lopez, K.L, Rizo, A.N, Tse, E, Lin, J, Scull, N.W, Thwin, A.C, Lucius, A.L, Shorter, J, Southworth, D.R.
Deposit date:2020-03-04
Release date:2020-05-06
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
6W23
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BU of 6w23 by Molmil
ClpA Disengaged State bound to RepA-GFP (Focused Classification)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ...
Authors:Lopez, K.L, Rizo, A.N, Tse, E, Lin, J, Scull, N.W, Thwin, A.C, Lucius, A.L, Shorter, J, Southworth, D.R.
Deposit date:2020-03-04
Release date:2020-05-06
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
6W24
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BU of 6w24 by Molmil
ClpA Engaged2 State bound to RepA-GFP (Focused Classification)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ...
Authors:Lopez, K.L, Rizo, A.N, Tse, E, Lin, J, Scull, N.W, Thwin, A.C, Lucius, A.L, Shorter, J, Southworth, D.R.
Deposit date:2020-03-04
Release date:2020-05-06
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis.
Nat.Struct.Mol.Biol., 27, 2020
6E0G
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BU of 6e0g by Molmil
Mitochondrial peroxiredoxin from Leishmania infantum after heat stress without unfolding client protein
Descriptor: mitochondrial 2-cys-peroxiredoxin
Authors:Teixeira, F, Tse, E, Makepeace, K.A.T, Borchers, C.H, Castro, H, Tomas, A.M, Poole, L.B, Southworth, D.R, Jakob, U.
Deposit date:2018-07-06
Release date:2019-02-20
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Chaperone activation and client binding of a 2-cysteine peroxiredoxin.
Nat Commun, 10, 2019
6E0F
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BU of 6e0f by Molmil
Mitochondrial peroxiredoxin from Leishmania infantum in complex with unfolding client protein after heat stress
Descriptor: mitochondrial 2-cys-peroxiredoxin
Authors:Teixeira, F, Tse, E, Makepeace, K.A.T, Borchers, C.H, Castro, H, Tomas, A.M, Poole, L.B, Southworth, D.R, Jakob, U.
Deposit date:2018-07-06
Release date:2019-02-20
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Chaperone activation and client binding of a 2-cysteine peroxiredoxin.
Nat Commun, 10, 2019
6OG2
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BU of 6og2 by Molmil
Focus classification structure of the hyperactive ClpB mutant K476C, bound to casein, post-state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Hyperactive disaggregase ClpB
Authors:Rizo, A.R, Lin, J.-B, Gates, S.N, Tse, E, Bart, S.M, Castellano, L.M, Dimaio, F, Shorter, J, Southworth, D.R.
Deposit date:2019-04-01
Release date:2019-06-12
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.
Nat Commun, 10, 2019
6OG3
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BU of 6og3 by Molmil
Focus classification structure of the hyperactive ClpB mutant K476C, bound to casein, NTD-trimer
Descriptor: Alpha S1-casein, Hyperactive disaggregase ClpB
Authors:Rizo, A.R, Lin, J.-B, Gates, S.N, Tse, E, Bart, S.M, Castellano, L.M, Dimaio, F, Shorter, J, Southworth, D.R.
Deposit date:2019-04-01
Release date:2019-06-12
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.
Nat Commun, 10, 2019
6OAY
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BU of 6oay by Molmil
Structure of the hyperactive ClpB mutant K476C, bound to casein, post-state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Alpha-S1-casein, Hyperactive disaggregase ClpB, ...
Authors:Rizo, A.R, Lin, J.-B, Gates, S.N, Tse, E, Bart, S.M, Castellano, L.M, Dimaio, F, Shorter, J, Southworth, D.R.
Deposit date:2019-03-18
Release date:2019-06-12
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.
Nat Commun, 10, 2019
6OG1
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BU of 6og1 by Molmil
Focus classification structure of the hyperactive ClpB mutant K476C, bound to casein, pre-state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Hyperactive disaggregase ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Rizo, A.R, Lin, J.-B, Gates, S.N, Tse, E, Bart, S.M, Castellano, L.M, Dimaio, F, Shorter, J, Southworth, D.R.
Deposit date:2019-04-01
Release date:2019-06-12
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.
Nat Commun, 10, 2019
6OAX
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BU of 6oax by Molmil
Structure of the hyperactive ClpB mutant K476C, bound to casein, pre-state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Alpha-S1-casein, Hyperactive disaggregase ClpB, ...
Authors:Rizo, A.R, Lin, J.-B, Gates, S.N, Tse, E, Bart, S.M, Castellano, L.M, Dimaio, F, Shorter, J, Southworth, D.R.
Deposit date:2019-03-18
Release date:2019-06-12
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.
Nat Commun, 10, 2019
8FCN
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BU of 8fcn by Molmil
Cryo-EM structure of p97:UBXD1 VIM-only state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCT
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BU of 8fct by Molmil
Cryo-EM structure of p97:UBXD1 lariat mutant
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCP
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BU of 8fcp by Molmil
Cryo-EM structure of p97:UBXD1 para state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCR
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BU of 8fcr by Molmil
Cryo-EM structure of p97:UBXD1 H4-bound state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (4.12 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCL
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BU of 8fcl by Molmil
Cryo-EM structure of p97:UBXD1 closed state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.51 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023
8FCQ
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BU of 8fcq by Molmil
Cryo-EM structure of p97:UBXD1 PUB-in state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 6
Authors:Braxton, J.R, Tucker, M.R, Tse, E, Southworth, D.R.
Deposit date:2022-12-01
Release date:2023-06-21
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (3.93 Å)
Cite:The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions.
Nat.Struct.Mol.Biol., 30, 2023

 

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